Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue

Serpa, Marianna Sampaio; Mafra, Rodrigo Porpino; Queiroz, Salomão Israel Monteiro Lourenço; Silva, Leorik Pereira da; Souza, Lélia Batista de; Pinto, Leão Pereira

doi:10.1590/1807-3107bor-2018.vol32.0093

Cited by 12 publications

(9 citation statements)

References 43 publications

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“…Interpretation is further limited by the small sample size, especially for subgroup analyses. However, even with large cohorts and validated antibodies, staining results can vary depending on the representative tumor specimen and scoring method chosen [45].…”

Section: Discussionmentioning

confidence: 99%

EGFR and αvβ6 as Promising Targets for Molecular Imaging of Cutaneous and Mucosal Squamous Cell Carcinoma of the Head and Neck Region

Baart

Duijn

Egmond

et al. 2020

Cancers

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R0 resection is paramount in cutaneous squamous cell carcinoma (CSCC) and head and neck squamous cell carcinoma (HNSCC). However, in the setting of recurrence, immunocompromised patients, or non-keratinizing squamous cell carcinoma (SCC) with a spindle growth pattern, tumor borders are difficult, if not impossible, to determine. Fluorescence-guided surgery (FGS) aids in this differentiation. Potential targets for FGS of CSCC and HNSCC were evaluated. Most sections stained intensely for αvβ6 and epidermal growth factor receptor (EGFR) on tumor cells. Normal epithelium stained less for αvβ6 than for EGFR. In addition, soft tissue and stroma stained negative for both, allowing for clear discrimination of the soft tissue margin. Tumor cells weakly expressed urokinase plasminogen activator receptor (uPAR) while expression on stromal cells was moderate. Normal epithelium rarely expressed uPAR, resulting in clear discrimination of superficial margins. Tumors did not consistently express integrin β3, carcinoembryonic antigen, epithelial cell adhesion molecule, or vascular endothelial growth factor A. In conclusion, αvβ6 and EGFR allowed for precise discrimination of SSC at the surgically problematic soft tissue margins. Superficial margins are ideally distinguished with uPAR. In the future, FGS in the surgically challenging setting of cutaneous and mucosal SCC could benefit from a tailor-made approach, with EGFR and αvβ6 as targets.

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Section: Discussionmentioning

confidence: 99%

EGFR and αvβ6 as Promising Targets for Molecular Imaging of Cutaneous and Mucosal Squamous Cell Carcinoma of the Head and Neck Region

Baart

Duijn

Egmond

et al. 2020

Cancers

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“…They found a global elevation of both proteases, without a true superiority of either the activator or inhibitor of plasminogen [104]. Serpa et al also found elevated uPA levels in a similar study conducted on human tongue SCC and showed that SCC cells had an elevation in the expression of uPAR [105]. Baker et al conducted a more complete study and showed an elevation in uPA, uPAR, PAI-1 and PAI-2 expression in human OSCC tumor tissue.…”

Section: Biological/fundamental Research Contributionsmentioning

confidence: 99%

Thrombosis Risk Associated with Head and Neck Cancer: A Review

Haen

Mège

Crescence

et al. 2019

IJMS

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Venous thromboembolism (VTE) is a common complication for cancer patients. VTE-associated risk varies according to the type of tumor disease. Head and neck cancer is a common cancer worldwide, and most tumors are squamous cell carcinomas due to tobacco and alcohol abuse. The risk of VTE associated with head and neck (H&N) cancer is considered empirically low, but despite the high incidence of H&N cancer, few data are available on this cancer; thus, it is difficult to state the risk of VTE. Our review aims to clarify this situation and tries to assess the real VTE risk associated with H&N cancer. We report that most clinical studies have concluded that there is a very low thrombosis risk associated with H&N cancer. Even with the biases that often exist, this clinical review seems to confirm that the risk of VTE was empirically hypothesized. Furthermore, we highlight that H&N cancer has all the biological features of a cancer associated with a high thrombosis risk, including a strong expression of procoagulant proteins, modified thrombosis/fibrinolysis mechanisms, and secretions of procoagulant microparticles and procoagulant cytokines. Thus, this is a paradoxical situation, and some undiscovered mechanisms that could explain this clinical biological ambivalence might exist.

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“…In the colorectal, stomach, and oral cavity, increased expression of uPA was observed. Marianna et al reported that uPA is highly expressed in high-grade tumors and in the worst invasive mode, and is involved in the progression of OSTCC to poor prognosis (23). Serpin family E member 1 (SERPINE1), a serine proteinase inhibitor (serpin), is the main inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA).…”

Section: Discussionmentioning

confidence: 99%

Discovery Potential Therapeutic Drugs for Oral Tongue Squamous Cell Carcinoma Based on Text Mining and Data Analysis

Yang

Wang

et al. 2021

Preprint

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Background: Oral tongue squamous cell carcinoma (OTSCC) is the most common malignant tumor of the oral cavity. The aim of this study was to use text mining and data analysis to discover some existing drugs that target genes and to explore potential therapeutic drugs for OTSCC. Methods: We used the text mining tool pubmed2ensembl to extract genes associated with OTSCC, and two datasets (GSE30784, GSE23558) from Gene Expression Omnibus (GEO) were used for the data analysis. Then, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed for the intersection of the three gene sets. Protein-protein interaction (PPI) network was constructed by STRING, gene module analysis was performed using the Molecular Complex Detection (MCODE), a plug-in in Cytoscape. Lastly, a database of drug-gene interactions was used to identify significant genes to explore potential drugs for the treatment of OTSCC.Results: We produced 403 unique genes associated with oral tongue squamous cell carcinoma through text mining. GSE23558 and GSE 30784 obtained 1637 and 1159 differentially expressed genes (DEGs) through data analysis, respectively. A total of 28 genes were obtained from the intersection gene sets, including 20 up-regulated genes and 8 down-regulated genes. We screened the most significant modules by using MCODE, among which 8 genes were associated with oral tongue squamous cell carcinoma as core genes. Eventually, nine drugs were found to target eight genes.Conclusions: In this study, PLAU, SERPINE1, MMP1, MMP3, MMP10, CXCL10, CXCL12, and SPP1 were potentially key genes involved in the treatment of OTSCC. Furthermore, 12 drugs were identified as potential therapeutic agents for oral tongue squamous cell carcinoma treatment and management

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Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue

Cited by 12 publications

References 43 publications

EGFR and αvβ6 as Promising Targets for Molecular Imaging of Cutaneous and Mucosal Squamous Cell Carcinoma of the Head and Neck Region

EGFR and αvβ6 as Promising Targets for Molecular Imaging of Cutaneous and Mucosal Squamous Cell Carcinoma of the Head and Neck Region

Thrombosis Risk Associated with Head and Neck Cancer: A Review

Discovery Potential Therapeutic Drugs for Oral Tongue Squamous Cell Carcinoma Based on Text Mining and Data Analysis

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