Expression of uterine and cervical epithelial cadherin during relaxin-induced growth in pigs

Ryan, PL; Baum, DL; Lenhart, J. R.; Ohleth, KM; Bagnell, Carol A.

doi:10.1530/rep.0.1220929

Cited by 18 publications

(7 citation statements)

References 3 publications

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“…2006a). Data are consistent with other studies showing that RLX increases uterine LE height in pre‐pubertal gilts (Ryan et al. 2001) and is important for maintenance of reproductive epithelia in RLX‐null mice (Zhao et al.…”

Section: Relaxin Receptor Expression and Functionality In The Neonatasupporting

confidence: 92%

Epigenetic Programming of Porcine Endometrial Function and the Lactocrine Hypothesis

Bartol

Wiley

Bagnell

2008

Reprod Domestic Animals

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Epigenetic programs controlling development of the female reproductive tract (FRT) are influenced by the effects of naturally occurring bioactive agents on patterns of gene expression in FRT tissues during organizationally critical periods of foetal and perinatal life. Aberrations in such important cellular and molecular events, as may occur with exposure to natural or manmade steroid or peptide receptor-modulating agents, disrupt the developmental program and can change the developmental trajectory of FRT tissues, including the endometrium, with lasting consequences. In the pig, as in other mammals, maternal programming of FRT development begins pre-natally and is completed post-natally, when maternal effects on development can be communicated via signals transmitted in milk. Studies involving relaxin (RLX), a prototypic milk-borne morphoregulatory factor (MbF), serve as the basis for ongoing efforts to identify maternal programming events that affect uterine and cervical tissues in the neonatal pig. Data support the lactocrine hypothesis for delivery of MbFs to neonates as a specific consequence of nursing. Components of a maternally driven lactocrine mechanism for RLX-mediated signalling in neonatal FRT tissues, including evidence that milk-borne RLX is delivered into the neonatal circulation where it can act on RLX receptor (RXFP1)-positive neonatal tissues to affect their development, are in place in the pig. The fact that all newborn mammals drink milk extends the timeframe of maternal influence on neonatal development across many species. Thus, lactocrine transmission of milk-borne developmental signals is an element of the maternal epigenetic programming equation that deserves further study.

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Section: Relaxin Receptor Expression and Functionality In The Neonatasupporting

confidence: 92%

Epigenetic Programming of Porcine Endometrial Function and the Lactocrine Hypothesis

Bartol

Wiley

Bagnell

2008

Reprod Domestic Animals

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“…Bagnell, submitted for publication). These data are consistent with other studies showing that RLX increases uterine luminal epithelial height in prepubertal gilts27 and is important for maintenance of reproductive epithelia in RLX‐null mice 28. Administration of RLX to gilts from birth increased uterine epithelial height on PND 2 ( P <.05), despite the fact that there was no relaxin‐induced uterine weight gain.…”

Section: Neonatal Uterotrophic Response To Relaxinsupporting

confidence: 92%

Effects of Relaxin on Neonatal Porcine Uterine Growth and Development

Bagnell

Yan

Wiley

et al. 2005

Annals of the New York Academy of Sciences

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Relaxin (RLX), a key reproductive hormone in pigs, stimulates uterine growth in pregnant and prepubertal gilts and in neonates 2 weeks after birth. The neonatal uterotrophic response to RLX is developmentally regulated and estrogen receptor dependent because RLX fails to increase uterine weight in the absence of estrogen receptor (ER)-alpha or when the ER is chemically inactivated. However, the role of RLX and insulin-like peptide-3 receptors, LGR7 and LGR8, respectively, in the neonatal uterotrophic response is unknown. Current studies focus on direct (LGR7/8-mediated) and indirect (ER-mediated) effects of RLX in the neonatal porcine uterus. Porcine LGR7 and LGR8 cDNAs were cloned and used as probes to identify uterine transcripts for LGR7 and LGR8, which increased from birth (postnatal day [PND] 0) to PND 14, a critical period for porcine uterine development. In situ hybridization showed that endometrial signals for both LGR7 and LGR8 are predominantly stromal during this period. Administration of RLX on PND 0, before onset of uterine ER expression, increased uterine luminal epithelial height (P < .05) but not uterine weight in the LGR7/8-positive uterus on PND 2. However, RLX increased both uterine weight and luminal epithelial height by PND 14 (P < .05), after overt endometrial ER expression. Aberrant ER activation between PND 0 and 14 alters the uterine organizational program and affects the function of adult porcine uterine tissues. Present data suggest that crosstalk between LGR7/8 and ER may be involved in estrogen-sensitive morphoregulatory events that are central to the development of an optimally functional adult uterus in the pig.

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“…The administration of P1 relaxin promotes growth of the uterine myometrium and endometrium in nonpregnant rodents and pigs (2, 139 -142). Uterotropic effects of relaxin in nonpregnant rats and/or pigs were reported to be associated with dilation of small arteries and/or veins (123) and increased content of water, protein, collagen, glycogen, DNA, IGFs, IGF-binding proteins, connexins, E-cadherin, VEGF, and tissue inhibitor of matrix metalloproteinases (TIMPs) (2,(142)(143)(144)(145)(146). The uterotropic effects of relaxin are markedly influenced by estrogen.…”

Section: Effects Between Implantation and Parturitionmentioning

confidence: 99%

Relaxin’s Physiological Roles and Other Diverse Actions

2004

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Relaxin has vital physiological roles in pregnant rats, mice, and pigs. Relaxin promotes growth and softening of the cervix, thus facilitating rapid delivery of live young. Relaxin also promotes development of the mammary apparatus, thus enabling normal lactational performance. The actions of relaxin on the mammary apparatus vary among species. Whereas relaxin is required for development of the mammary nipples in rats and mice, it is essential for prepartum development of glandular parenchyma in pregnant pigs. During pregnancy relaxin also inhibits uterine contractility and promotes the osmoregulatory changes of pregnancy in rats. Recent studies with male and nonpregnant female rodents revealed diverse therapeutic actions of relaxin on nonreproductive tissues that have clinical implications. Relaxin has been reported to reduce fibrosis in the kidney, heart, lung, and liver and to promote wound healing. Also, probably through its vasodilatory actions, relaxin protects the heart from ischemia-induced injury. Finally, relaxin counteracts allergic reactions. Knowledge of the diverse physiological and therapeutic actions of relaxin, coupled with the recent identification of relaxin receptors, opens numerous avenues of investigation that will likely sustain a high level of research interest in relaxin for the foreseeable future.

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Expression of uterine and cervical epithelial cadherin during relaxin-induced growth in pigs

Cited by 18 publications

References 3 publications

Epigenetic Programming of Porcine Endometrial Function and the Lactocrine Hypothesis

Epigenetic Programming of Porcine Endometrial Function and the Lactocrine Hypothesis

Effects of Relaxin on Neonatal Porcine Uterine Growth and Development

Relaxin’s Physiological Roles and Other Diverse Actions

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