Expression of Vascular Adhesion Protein-1 in Atopic Eczema

Abstract

Background:Vascular adhesion protein-1 (VAP-1) is an adhesion molecule with an enzymatic activity which partakes in the migration process of lymphocytes. The aim of this study was to investigate VAP-1 expression in atopic eczema (AE) in comparison with healthy controls and psoriatic individuals. Material and Methods:Forty adult patients suffering from AE aged between 18 and 56 years were included in the study. The control group consisted of 35 healthy volunteers aged between 19 and 49 years and of 71 psoriatic patients aged between 23 and 89 years. The serum concentration of soluble VAP-1 (sVAP-1) was evaluated by ELISA and VAP-1 expression in the skin by immunohistochemistry. Results: Serum level of sVAP-1 in AE patients before treatment was significantly higher compared with healthy volunteers. Similarly, a higher mean number of VAP-1-positive vessels was found in both lesional and nonlesional atopic skin compared with healthy skin. Treatment of AE resulted in a significant reduction in the serum level of sVAP-1. On the other hand, both the serum level of sVAP-1 and the number of dermal vessels with expression of VAP-1 were significantly lower in AE patients compared with psoriatic individuals. Conclusion: This study indicates the important role of VAP-1 in the pathogenesis of chronic inflammatory cutaneous disorders, including AE.

Circulating form of human vascular adhesion protein‐1 (VAP‐1): Decreased serum levels in progression of colorectal cancer and predictive marker of lymphatic and hepatic metastasis

“…Because sinusoidal endothelial cells in liver express VAP-1, which mediates binding of TILs to hepatocellular carcinoma, it is possible that VAP-1 participates in TIL homing [8]. Furthermore, the soluble form of VAP-1 (sVAP-1) is found in serum, which is believed to be derived from the membrane bound form, and which is elevated in certain diseases such as diabetes and some, but not all inflammatory diseases [9,10]. There is strong constitutive expression of VAP-1 on hepatic endothelia, and in inflammatory liver diseases, sVAP-1 is clearly elevated.…”

Atopic Dermatitis in 2008

“…These findings were subsequently confirmed by additional investigators [48]. Most recently, other investigators have found an increased expression of yet another endothelial cell adhesion molecule -vascular adhesion protein-1, an adhesion molecule with an enzymatic activity which partakes in the migration process of lymphocytes -in the dermal microvascular endothelial cells of atopic patients, compared to normal individuals [49]. The latter finding provides additional support for the role of adhesion molecules in aiding the inflammatory process in atopic dermatitis and for the role of lymphocytes.…”

Evaluation of serum and tissue levels of VAP-1 in colorectal cancer

“…This control group is therefore different to the healthy controls described in the other studies [ 10 , 19 ], but more relevant as a comparator group with CRC patients. Increased levels of sVAP-1 have been reported in inflammatory diseases such as ectopic eczema [ 20 ], liver cirrhosis [ 11 ] and multiple sclerosis [ 21 ]. There is notably no increase in sVAP-1 levels in inflammatory bowel disease compared to healthy controls [ 22 ], despite increased tissue levels of VAP-1.…”