2006
DOI: 10.1159/000097905
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Expression of Vascular Endothelial Growth Factor A, Matrix Metalloproteinase 9 and Extravascular Matrix Patterns in Iris and Ciliary Body Melanomas

Abstract: Purpose: It was the aim of this study to assess the expression of vascular endothelial growth factor (VEGF)-A, matrix metalloproteinase (MMP)-9 and extravascular matrix patterns (EMPs) in iris and ciliary body melanomas and their correlations with histopathologic parameters. Methods: The study was conducted on 3 iris and 15 ciliary body melanomas. All tumors were subjected to immunohistochemical techniques for VEGF-A and MMP-9 expressions, the presence of EMPs was assessed, and routine paraffin sections were s… Show more

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Cited by 13 publications
(7 citation statements)
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“…In other studies, human anterior uveal melanomas expressed high levels of VEGF as assessed by immunohistochemistry 21,52,53 . Elevated expression levels of VEGF, VEGFR1, and VEGFR2 have been documented in human eyes with intraocular tumors including retinoblastoma, iris and ciliary body adenomas, and choroidal melanomas 21,54,55 . Members of the VEGF family of proteins have been identified in a variety of canine nonocular neoplastic diseases including lymphoma, 56 cutaneous squamous cell carcinoma, 57 mammary carcinoma, 58 hemangiosarcoma, 30 and mastocytoma 59 .…”
Section: Discussionmentioning
confidence: 95%
“…In other studies, human anterior uveal melanomas expressed high levels of VEGF as assessed by immunohistochemistry 21,52,53 . Elevated expression levels of VEGF, VEGFR1, and VEGFR2 have been documented in human eyes with intraocular tumors including retinoblastoma, iris and ciliary body adenomas, and choroidal melanomas 21,54,55 . Members of the VEGF family of proteins have been identified in a variety of canine nonocular neoplastic diseases including lymphoma, 56 cutaneous squamous cell carcinoma, 57 mammary carcinoma, 58 hemangiosarcoma, 30 and mastocytoma 59 .…”
Section: Discussionmentioning
confidence: 95%
“…It is well established that elevated VEGF expression is commonly associated with neoplasia and several reports document VEGF expression by human intraocular tumors 26,27,55–58 . A variety of intraocular neoplasms were included in this study, including uveal melanoma, ciliary body adenoma, lymphoma, spindle cell tumor and an anaplastic tumor, with a mean aqueous humor concentration of 1400 pg/mL.…”
Section: Discussionmentioning
confidence: 99%
“…Tumor cells and vessels were positive for VEGF peripherally, but were only infrequently, weakly positive in the center of the tumors. Since vessels are strongly positive for VEGF in intraocular tumors 72 and vessels are often used for VEGF internal positive controls, 73 inadequate tissue fixation may have contributed to poor tumor staining. Furthermore, VEGF stromal positivity is strongly associated with extraocular malignancy (carcinomas) 73 and may be expected to be poorer in these benign intraocular tumors.…”
Section: Discussionmentioning
confidence: 99%