Expression of Vascular Endothelial Growth Factor in Pulmonary Aspergilloma.

Inoue, Koji; Matsuyama, Wataru; Hashiguchi, Teruto; Wakimoto, Joeji; Hirotsu, Yasunobu; Kawabata, Masaharu; Arimura, Kimiyoshi; Osame, Mitsuhiro

doi:10.2169/internalmedicine.40.1195

Cited by 24 publications

(19 citation statements)

References 9 publications

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“…Consistent with previous data that levels of VEGF are significantly elevated in inflammatory disorders, including lung inflammatory disease,6,7,18,19 our present results also demonstrated that VEGF levels were increased in inflammatory lung diseases, such as bronchiectasis, aspergilloma, post-tuberculosis destroyed lung, and pneumonia, when compared with published normal values 20,21. Additionally, elevated VEGF levels correlated with severity of inflammation.…”

Section: Discussionsupporting

confidence: 92%

“…The required sample size was calculated based on VEGF levels according to the presence of hemoptysis in patients with asperilloma 6. Assuming 437±164 pg/mL of VEGF in the hemoptysis group and 162±102 pg/mL in the no hemoptysis group, a sample size of 42 patients (21 per group) was required to detect a 120 pg/mL difference between the two groups with a power of 90% and α error of 0.05 using a two-tailed test 17.…”

Section: Methodsmentioning

confidence: 99%

“…Antiangiogenic agents have received widespread attention as targets for lung cancer therapy 8,9. Recent studies reported that VEGF elevation correlates significantly with the presence of hemoptysis in patients with pulmonary aspergilloma 6. Another major factor involved in angiogenesis, angiopoietin-2 (Ang-2), is also induced by hypoxemia10 and plays an important role in initiating vessel sprouting in concert with VEGF 11,12.…”

Section: Introductionmentioning

confidence: 99%

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Serum Vascular Endothelial Growth Factor and Angiopoietin-2 Are Associated with the Severity of Systemic Inflammation Rather than the Presence of Hemoptysis in Patients with Inflammatory Lung Disease

et al. 2012

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PurposeVascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) are major mediators of angiogenesis and are induced by tissue inflammation and hypoxia. The purpose of this study was to investigate whether serum VEGF and Ang-2 are associated with the presence of hemoptysis and the extent of systemic inflammation in patients with inflammatory lung diseases.Materials and MethodsWe prospectively enrolled 52 patients with inflammatory lung disease between June 2008 and October 2009.ResultsThe median values of VEGF and Ang-2 were 436 pg/mL and 2383 pg/mL, respectively. There was a significant positive correlation between serum Ang-2 and VEGF levels. VEGF levels were not significantly different according to the presence of hemoptysis. C-reactive protein (CRP) and Ang-2 level were significantly higher in patients without hemoptysis (n=26) than in those with hemoptysis (n=26; p<0.001 and p<0.001, respectively). CRP and arterial oxygen tension (PaO2) were significantly correlated with both serum VEGF (p=0.032 and p=0.016, respectively) and Ang-2 levels (p<0.001 and p=0.041, respectively), after adjusting for other factors. Age and the absence of hemoptysis were factors correlated with serum Ang-2 levelsConclusionOur study suggests that serum VEGF and Ang-2 levels are associated with PaO2 and the severity of inflammation rather than the presence of hemoptysis in patients with inflammatory lung diseases. Thus, hemoptysis may not be mediated by increased serum levels of VEGF and Ang-2 in patients with inflammatory lung diseases, and further studies are required to determine the mechanisms of hemoptysis.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum Vascular Endothelial Growth Factor and Angiopoietin-2 Are Associated with the Severity of Systemic Inflammation Rather than the Presence of Hemoptysis in Patients with Inflammatory Lung Disease

et al. 2012

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“…VEGF is one of the predictive serum markers for the likelihood of developing hemoptysis. 11 However, results of from our study were not in consistence with previous report regarding hemoptysis. In our study, VEGF level not in serum, but in BALF was measured, and we did not find any correlation between BALF VEGF levels and the presence of hemoptysis.…”

Section: Discussioncontrasting

confidence: 99%

Vascular Endothelial Growth Factor in Bronchoalveolar Lavage Fluid in Sulfur Mustard Exposed Lung Patients

Karami¹,

Ghanei²,

Alaeddini³

et al. 2011

OMJ

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“…Similarly, Aspergillus clavatus secretes cytochalasin E, which is a potent and selective inhibitor of capillary endothelial cell proliferation in an experimental model (16). On the other hand, it has been shown that in patients with aspergillomas, the levels of vascular endothelial growth factor (VEGF) in serum were raised, and the level was related to the area of lung involvement, PaO 2 level, and the presence of hemoptysis (8). Furthermore, the expression of VEGF was high in alveolar macrophages in the lesion of aspergillomas, and VEGF expression in macrophages was induced by hypoxia and lactate and its expression promoted angiogenesis and increased vascular permeability (5,19).…”

Section: Discussionmentioning

confidence: 99%

Association of Presence of Aspergillus Antibodies with Hemoptysis in Patients with Old Tuberculosis or Bronchiectasis but No Radiologically Visible Mycetoma

et al. 2004

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Old tuberculosis and bronchiectasis are the two most important causes of chronic structural changes of lungs in our locality. In the absence of radiologically visible mycetoma, the cause of hemoptysis in these two groups of patients is largely unknown. A 17-month prospective study was carried out to compare the prevalence of Aspergillus fumigatus and Aspergillus flavus antibodies in hemoptysis patients with old tuberculosis or bronchiectasis but no radiologically visible mycetoma (cases, n ‫؍‬ 38), hemoptysis patients with other diagnosis (control group 1, n ‫؍‬ 29), and patients with old tuberculosis or bronchiectasis but no hemoptysis (control group 2, n ‫؍‬ 47) by a recently developed sensitive and specific A. fumigatus and A. flavus antibody assay. There were a significantly larger number of patients with antibody against A. fumigatus or A. flavus among the cases than among the patients in control groups 1 and 2 (P < 0.05 in both comparisons). Molds were not recovered from any of the patients. Among the 10 cases with Aspergillus antibody, eight and two had antibody against A. flavus and A. fumigatus, respectively. We conclude that there was an association between the presence of Aspergillus antibodies and hemoptysis in patients with old tuberculosis or bronchiectasis, suggesting that these patients probably had occult infections caused by the corresponding fungi. Development of serological tests against other Aspergillus species as well as other causes of mycetoma will probably increase the detection of occult mold infections in patients with existing parenchymal lung diseases, and treatment of fungal microinvasion may help to alleviate hemoptysis in these patients with bronchiectasis or old tuberculosis who have Aspergillus antibodies.

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Expression of Vascular Endothelial Growth Factor in Pulmonary Aspergilloma.

Abstract: Objective Vascular endothelial growth factor

Cited by 24 publications

References 9 publications

Serum Vascular Endothelial Growth Factor and Angiopoietin-2 Are Associated with the Severity of Systemic Inflammation Rather than the Presence of Hemoptysis in Patients with Inflammatory Lung Disease

Serum Vascular Endothelial Growth Factor and Angiopoietin-2 Are Associated with the Severity of Systemic Inflammation Rather than the Presence of Hemoptysis in Patients with Inflammatory Lung Disease

Vascular Endothelial Growth Factor in Bronchoalveolar Lavage Fluid in Sulfur Mustard Exposed Lung Patients

Association of Presence of Aspergillus Antibodies with Hemoptysis in Patients with Old Tuberculosis or Bronchiectasis but No Radiologically Visible Mycetoma

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