Expression of vascular endothelial growth factor and its receptors after mandibular distraction osteogenesis

Byun, June‐Ho; Park, B.-W.; Kim, J.-R.; Lee, J.-H.

doi:10.1016/j.ijom.2006.10.013

Cited by 37 publications

(31 citation statements)

References 32 publications

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“…Notably, these cells also express VEGFR-1 and -2, which bind VEGF, as well as the osteoclasts (Byun et al, 2007;Jacobsen et al, 2008;Marini et al, 2012). This supports that VEGF may act in an autocrine or paracrine manner during bone morphogenesis.…”

Section: Discussionmentioning

confidence: 99%

Differential expression of vascular endothelial growth factor in human fetal skeletal site-specific tissues: Mandible versus femur

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Differential expression of vascular endothelial growth factor in human fetal skeletal site-specific tissues: Mandible versus femur

et al. 2015

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“…VEGFR-1 (also known as Flt-1) is expressed in osteoblasts during osteogenesis in vitro [Deckers et al, 2000;Street and Lenehan, 2009] and in vivo [Byun et al, 2007;Otomo et al, 2007]. The expression of this receptor is dependent on differentiation and coincides with the expression of its ligand [Deckers et al, 2000].…”

Section: Discussionmentioning

confidence: 99%

Profiling the changes in signaling pathways in ascorbic acid/β‐glycerophosphate‐induced osteoblastic differentiation

Chaves‐Neto¹,

Queiroz²,

Milani³

et al. 2011

J of Cellular Biochemistry

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Despite numerous reports on the ability of ascorbic acid and β-glycerophosphate (AA/β-GP) to induce osteoblast differentiation, little is known about the molecular mechanisms involved in this phenomenon. In this work, we used a peptide array containing specific consensus sequences (potential substrates) for protein kinases and traditional biochemical techniques to examine the signaling pathways modulated during AA/β-GP-induced osteoblast differentiation. The kinomic profile obtained after 7 days of treatment with AA/β-GP identified 18 kinase substrates with significantly enhanced or reduced phosphorylation. Peptide substrates for Akt, PI3K, PKC, BCR, ABL, PRKG1, PAK1, PAK2, ERK1, ERBB2, and SYK showed a considerable reduction in phosphorylation, whereas enhanced phosphorylation was observed in substrates for CHKB, CHKA, PKA, FAK, ATM, PKA, and VEGFR-1. These findings confirm the potential usefulness of peptide microarrays for identifying kinases known to be involved in bone development in vivo and in vitro and show that this technique can be used to investigate kinases whose function in osteoblastic differentiation is poorly understood.

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“…A growing number of reports suggest that VEGF has autocrine effects on nonvascular cells such as neuronal cells (45), muscle (42), and bone (46), and these findings challenge the dogma that VEGF serves solely as a paracrine growth factor specifically targeting endothelial cells and may help to explain why VEGF is expressed in normoxic adult tissue (47), where there is no active ongoing angiogenesis. Furthermore, VEGF has been found to be coordinately regulated as part of the myogenic differentiation program and serves an autocrine function, regulating skeletal myogenesis (48).…”

Section: Grundtman Et Almentioning

confidence: 99%

Vascular endothelial growth factor is highly expressed in muscle tissue of patients with polymyositis and patients with dermatomyositis

Grundtman¹,

Tham²,

Ulfgren³

et al. 2008

Arthritis & Rheumatism

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Objective. To investigate the expression of vascular endothelial growth factor (VEGF) in muscle biopsy specimens and serum from patients with polymyositis and patients with dermatomyositis compared with that in healthy control subjects.Methods. Muscle biopsy specimens from 33 patients with polymyositis or dermatomyositis and 15 healthy control subjects and serum samples from 56 patients and 56 healthy control subjects were analyzed. Patients were categorized into 3 groups, depending on disease duration and the presence or absence of inflammatory infiltrates. The expression of VEGF and the vessel marker CD31 in muscle was analyzed by immunohistochemistry, the expression of VEGF messenger RNA (mRNA) was analyzed by in situ hybridization, and serum levels of VEGF were determined by enzymelinked immunosorbent assay.Results. Patients with polymyositis or dermatomyositis in the early or chronic phase without inflammatory infiltrates had a decreased total number of capillaries compared with healthy individuals. In patients with early disease without inflammatory infil-

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Expression of vascular endothelial growth factor and its receptors after mandibular distraction osteogenesis

Cited by 37 publications

References 32 publications

Differential expression of vascular endothelial growth factor in human fetal skeletal site-specific tissues: Mandible versus femur

Differential expression of vascular endothelial growth factor in human fetal skeletal site-specific tissues: Mandible versus femur

Profiling the changes in signaling pathways in ascorbic acid/β‐glycerophosphate‐induced osteoblastic differentiation

Vascular endothelial growth factor is highly expressed in muscle tissue of patients with polymyositis and patients with dermatomyositis

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