Expression of vascular endothelial growth factor and its receptors in rosacea

Smith, Justine R.; Lanier, Virginia; Braziel, Rita M.; Falkenhagen, Katherine M.; White, Clifton; Rosenbaum, James T.

doi:10.1136/bjo.2006.101121

Cited by 90 publications

(46 citation statements)

References 20 publications

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“…Angiogenesis induced by cathelicidin is mediated by an increase in vascular endothelial growth factor (VEGF) in epidermal keratinocytes, and could represent an explanation for these vascular events in rosacea (25) . An increase in expression of VEGF and its receptors was demonstrated in the skin of patients with rosacea (35,36) .…”

Section: Etiology and Pathophysiologymentioning

confidence: 99%

Ocular rosacea: a review

Vieira¹,

Höfling-Lima²,

Mannis³

2012

Arq. Bras. Oftalmol.

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Section: Etiology and Pathophysiologymentioning

confidence: 99%

Ocular rosacea: a review

Vieira¹,

Höfling-Lima²,

Mannis³

2012

Arq. Bras. Oftalmol.

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“…15 Despite these mediators having been identified, the primary initiating mechanism for inflammation is still not clear.…”

Section: Pathophysiologymentioning

confidence: 99%

Ocular Rosacea—a Review

Dhingra¹,

Malhotra²,

Jain³

2017

US Ophthalmic Review

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Ocular rosacea, a disease often associated with acne rosacea, can present with a variety of clinical features, which are often nonspecific. However, in about one-third of cases, it may occur as an isolated entity without skin involvement. Appropriate diagnosis and management is essential as potentially sight-threatening corneal involvement can occur in a significant number of patients if the condition remains unrecognized and untreated. Diagnosis remains mainly clinical and includes recognition of the commonly occurring signs of chronic blepharoconjunctivitis, lid margin telangiectasis,meibomian gland dysfunction, dry eyes, and corneal involvement in the form of vascularization, infiltration, and even perforation. Management depends on the severity of the disease, with milder forms being amenable to treatment with local measures like lid hygiene and topical lubricants, while more severe forms require treatment with systemic drugs including tetracyclines, azithromycin, erythromycin, or metronidazole and more aggressive local therapy with topical steroids and/or topical cyclosporine. Surgical treatment may be required to manage the sequelae of chronic ocular surface inflammation.

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“…Immunohistochemistry revealed increased VEGF expression in lesional versus nonlesional skin of rosacea patients. 128 Smith et al 129 showed expression of both VEGFR1 and 2 in rosacea vascular endothelium and infiltrating mononuclear cells.…”

Section: Hemangioendotheliomas Key Point D Antiangiogenic Treatment Hmentioning

confidence: 99%

Angiogenesis in cutaneous disease: Part II

Laquer

Hoang

Nguyen

et al. 2009

Journal of the American Academy of Dermatology

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This review will discuss the role of angiogenesis in specific cutaneous diseases. Scientific evidence now points to the role of angiogenesis in tumor development and many other cutaneous disorders. Angiogenesis is a complex process that involves angiogenic growth factors and inhibitors, many of which could be a potential target for pharmacologic intervention. Antiangiogenic agents have recently been applied to dermatologic diseases with promising efficacy. ( J Am Acad Dermatol 2009;61:945-58.)Learning objectives: After completing this learning activity, participants should be able to recognize cutaneous diseases where angiogenesis is likely to be an important factor, recognize scenarios where angiogenic therapy may be useful in conjunction with traditional therapies, and be able to use angiogenicmediating agents in the treatment of dermatologic disease.

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Expression of vascular endothelial growth factor and its receptors in rosacea

Cited by 90 publications

References 20 publications

Ocular rosacea: a review

Ocular rosacea: a review

Ocular Rosacea—a Review

Angiogenesis in cutaneous disease: Part II

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