Expression of vascular endothelial growth factor (VEGF) in normal oral mucosa, oral dysplasia and oral squamous cell carcinoma

Johnstone, S.; Logan, Richard M.

doi:10.1016/j.ijom.2006.09.017

Cited by 54 publications

(60 citation statements)

References 26 publications

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“…Numerous studies have focused on the mechanisms of corneal NV following LSCD 17,18 or other etiologies, 29 while others have reported differential expression of angiogenesis-related factors in cultivated corneal (CCE) and oral mucosal epithelial cells (COE). [20][21][22] Additionally, miscellaneous angiogenesis-related factors have been localized immunohistochemically in human corneas, [22][23][24][25]30,31 oral mucosa, 22,[32][33][34][35] and vascularized corneas 23,36,37 (see Supplementary Table S2 for a literature review, http://www. iovs.org/lookup/suppl/d oi:10.1167/iovs.11-9293/-/ DCSupplemental).…”

Section: Discussionmentioning

confidence: 99%

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Expression of Angiogenesis-Related Factors in Human Corneas after Cultivated Oral Mucosal Epithelial Transplantation

Chen

Yeh

Tsai

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 99%

“…20,31 oral mucosa, 20,35 and vascularized corneas. 36,37 On the other hand, subconjunctival injection of bevacizumab (Avastin, a humanized anti-VEGF antibody) has shown short-term beneficial effects for corneal NV secondary to graft rejection, 39 lipid keratopathy, 40 or other causes.…”

Section: Discussionmentioning

confidence: 99%

Expression of Angiogenesis-Related Factors in Human Corneas after Cultivated Oral Mucosal Epithelial Transplantation

Chen

Yeh

Tsai

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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“…This is accompanied by increase in blood vessel formation and increased blood supply. Increased expression of VEGF is seen in OSCC through all stages of disease progression [106][107][108]. Other factors that promote blood vessel formation and endothelial cell migration include, prostaglandin E2 (PGE 2 ) and TGF-β̣ are often overexpressed by tumor cells [109][110][111][112][113].…”

Section: Cdk2ap1-also Known As P12mentioning

confidence: 99%

Molecular mechanisms of head and neck cancer

Deshpande

Wong²

2008

Expert Review of Anticancer Therapy

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Background-With a global incidence rank of eight and a significant portion of head and neck malignancies (~90%), oral squamous cell carcinoma (OSCC) poses a major health risk and is one of the leading cause of mortality in developing nations [1]. Distribution of the incidence of OSCC varies across the world with south-central Asia and Africa leading, followed by eastern and central Europe, and to a lesser extent Australia, Japan, and the United States. Over the past few years there has been a drastic increase in the incidence of oral cancer in most parts of the world [2]. In the United States alone, with about 17 new cases/100,000, oral cancer is the fifth most common and sixth leading cause of cancer-related mortality per year [3].While men tend to have a higher incidence of OSCC (6.6/100,000) compared to women (2.9/100,000), there is an equal mortality rate between the sexes (50%).

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“…El hallazgo en relación a los vasos sanguíneos presentados en esta investigación, en las muestras pertenecientes al grupo expuesto al humo de cigarrillos con respecto al grupo control, la ubicación tan próxima al epitelio, de manera característica en el vértice de las papilas dérmicas podría proveer el aporte sanguíneo necesario para suplir la demanda de nutrientes requeridos por las células proliferando de forma incrementada (30).…”

Section: Cambios Histopatológicos De La Mucosa Bucal De Ratas Expuestunclassified

Cambios histopatológicos de la mucosa bucal de ratas expuestas al humo de cigarrillos

et al. 2014

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Flete Estrada A, Cáribas A, Payares G, Villarroel-Dorrego M. Cambios histopatológicos de la mucosa bucal de ratas expuestas al humo de cigarrillos RESUMENIntroducción: El propósito de esta investigación fue evaluar el efecto del humo del tabaco en la mucosa bucal "in vivo" usando un modelo animal. Materiales y métodos: La población de estudio estuvo constituida por 20 ratas hembras Sprague Dawley, 10 expuestas al humo de 10 cigarrillos diarios por 16 semanas (GEC) y un grupo control no expuesto (GC). Las ratas fueron sacrificadas y se extrajo la lengua para su estudio histopatológico. Variables categóricas fueron comparadas mediante la prueba U de Mann-Whitney. Valores p<0,05 fueron considerados estadísticamente significativos. Resultados: La mucosa lingual del GEC mostró mayores cambios epiteliales proliferativos que el GC, como hiperplasia basal (p= 0,001), acantosis (p= 0,0001), hipercromatismo y picnosis nuclear (p= 0,010 y 0,014 respectivamente), y displasia epitelial (p= 0,0001). En el corion de la mucosa del GEC se observó un incremento del infiltrado inflamatorio crónico (p= 0,007); y aunque no hubo aumento en el número de vasos sanguíneos en el GEC, es importante resaltar que la ubicación de los mismos fue muy próxima al epitelio de revestimiento expuesto al tabaco. Discusión: El presente estudio, usando un modelo animal, demuestra que el humo del tabaco induce cambios precoces en la arquitectura tisular y morfología de células epiteliales de la mucosa bucal de aspecto macroscópicamente sano.Palabras clave: Tabaquismo, modelo animal, cambios histológicos, mucosa bucal. SUMMARY Introduction:The purpose of this study was to evaluate the histopathological changes in oral tissues of rats exposed to tobacco smoke. Materials & methods: 20 female rats Sprague Dawley were included in the study and 10 rats exposed to environmental tobacco smoke of 10 cigarettes daily for 16 weeks. All animals were sacrificed and tissues extracted, died using H&E and finally evaluated under light microscope. Categorical variables were compared using U Mann-Whitney test. P values<0.05 were considered statistically significant. Results: Oral mucosa of rats exposed to tobacco showed augmented epithelial changes as basal hyperplasia basal (p= 0,001), acanthosis (p= 0,0001), nuclear hyperchromatism and picnosis (p= 0,010 y 0,014 respectively), and epithelial dysplasia (p= 0.0001). Increased chronic inflammatory infiltrate was also observed in this group (p= 0.007), as well as, a higher number of blood vessels although difference was not statistically significant. Discussion: Tobacco inhalation showed to produce tissue alterations of macroscopically healthy mucosa of rats. This study, using an animal model, demonstrated microscopical oral mucosa changes produced by tobacco smoke without clinical alterations. Cambios histopatológicos de la mucosa bucal de ratas expuestas al humo de cigarrillosHistopathological oral tissues changes of rats exposed to tobacco smoke

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Expression of vascular endothelial growth factor (VEGF) in normal oral mucosa, oral dysplasia and oral squamous cell carcinoma

Cited by 54 publications

References 26 publications

Expression of Angiogenesis-Related Factors in Human Corneas after Cultivated Oral Mucosal Epithelial Transplantation

Expression of Angiogenesis-Related Factors in Human Corneas after Cultivated Oral Mucosal Epithelial Transplantation

Molecular mechanisms of head and neck cancer

Cambios histopatológicos de la mucosa bucal de ratas expuestas al humo de cigarrillos

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