Expression of VEGF, iNOS, and eNOS is increased in cochlea of diabetic rat

Abstract

Increased cochlear expression of VEGF, iNOS, and eNOS was detected in the diabetic rat. Furthermore, increased permeability of BLB was evidenced by increased cochlear EB extravasation in the diabetic rat.

Increased risk of getting sudden sensorineural hearing loss in patients with chronic kidney disease: A population‐based cohort study

“…Microangiopathy was one of the proposed mechanisms for diabetic patients developing sensorineural hearing impairment. Meanwhile, several literatures have reported the association between microangiopathy and SSHL 35–38. Aimoni et al (2010) described that the risk of getting SSHL tended to increase as the number of cardiovascular risk factors increased 39.…”

Risk of Developing Sudden Sensorineural Hearing Loss in Diabetic Patients

“…Several studies have reported a consistent association between microangiopathy and SSHL (3,12,31,32). Aimoni et al (19) stated that the risk of developing SSHL tended to increase with increasing number of cardiovascular risk factors.…”

“…Medications that enhance microcirculation may benefit diabetic patients confronting the risk of SSHL, especially for diabetic patients of between 50 and 64 years of age and diabetic patients who require triple antidiabetic medication and diabetic patients who have developed new comorbidities of retinopathy and renal disease. Fortunately, with proper and timely management, some previous reports have shown an even better prognosis of SSHL in diabetic patients compared with nondiabetic patients (32).…”

Vascular dysfunction in the diabetic placenta: causes and consequences

“…1999). The microvasculature of the cochlea in STZ‐induced diabetic rats also shows a significant increase in VEGF (Liu et al 2008). The reported increases in placental VEGF in the diabetic placenta may well be behind the junctional changes and increased vascular leakage (Babawale et al.…”