Expression of voltage-dependent potassium channels in first trimester human placentae

Mistry, Hiten D.; Kurlak, Lesia O.; Whitley, Guy; Cartwright, Judith E.; Pipkin, Fiona Broughton; Tribe, Rachel M.

doi:10.1016/j.placenta.2014.02.008

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…KCNE5 thus far has been found to modify the function of most of the KCNQ family, Kv2.1 (and Kv2.1-Kv6.4 heteromers) and Kv4.3-KChIP2 (see details above and Table 1). KCNE5 transcripts were reportedly most highly expressed in human cardiac and skeletal muscle, the spinal cord and the brain 41 , and it is also found in human placenta, where its expression levels increase in pre-eclampsia 108–110 . In mouse embryo, Kcne5 was found in cranial nerve migrating crest cells, ganglia, and in somites and the myoepicardial layer 41 .…”

Section: Potential Role Of Kcne5 In Vivomentioning

confidence: 99%

KCNE4 and KCNE5: K+ channel regulation and cardiac arrhythmogenesis

Abbott

2016

Gene

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KCNE proteins are single transmembrane-segment voltage-gated potassium (Kv) channel ancillary subunits that exhibit a diverse range of physiological functions. Human KCNE gene mutations are associated with various pathophysiological states, most notably cardiac arrhythmias. Of the five isoforms in the human KCNE gene family, KCNE4 and the X-linked KCNE5 are, to date, the least-studied. Recently, however, interest in these neglected genes has been stoked by their putative association with debilitating or lethal cardiac arrhythmias. The sometimes-overlapping functional effects of KCNE4 and KCNE5 vary depending on both their Kv α subunit partner and on other ancillary subunits within the channel complex, but mostly fall into two contrasting categories either inhibition, or fine-tuning of gating kinetics. This review covers current knowledge regarding the molecular mechanisms of KCNE4 and KCNE5 function, human disease associations, and findings from very recent studies of cardiovascular pathophysiology in Kcne4−/− mice.

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Section: Potential Role Of Kcne5 In Vivomentioning

confidence: 99%

KCNE4 and KCNE5: K+ channel regulation and cardiac arrhythmogenesis

Abbott

2016

Gene

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Preeclampsia and transport of ions and small molecules: A literature review

Moura,

Nunes,

Crestani

et al. 2024

Placenta

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Placental ion channels: potential target of chemical exposure

Zhao

Pasanen

Rysä

2022

Biology of Reproduction

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The placenta is an important organ for the exchange of substances between the fetus and the mother, hormone secretion and fetoplacental immunological defense. Placenta has organ-specific distribution of ion channels and trophoblasts, and placental vessels express a large number of ion channels. Several placental house-keeping activities and pregnancy complications are at least partly controlled by ion channels, which are playing an important role in regulating hormone secretion, trophoblastic homeostasis, ion transport, and vasomotor activity. The function of several placental ion channels (Na, Ca and Cl ion channels, cation channel, nicotinic acetylcholine receptors and aquaporin-1) are known to be influenced by chemical exposure i.e. their responses to different chemicals have been tested and confirmed in experimental models. Here we review the possibility that placental ion channels are targets of toxicological concern in terms of placental function, fetal growth and development.

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Expression of voltage-dependent potassium channels in first trimester human placentae

Cited by 5 publications

References 17 publications

KCNE4 and KCNE5: K+ channel regulation and cardiac arrhythmogenesis

KCNE4 and KCNE5: K+ channel regulation and cardiac arrhythmogenesis

Preeclampsia and transport of ions and small molecules: A literature review

Placental ion channels: potential target of chemical exposure

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