Expression of VP1 protein of serotype A and O of foot-and-mouth disease virus in transgenic sunnhemp plants and its immunogenicity for guinea pigs

Rao, Jyothsna; Agrawal, Pushpa; Mohammad, Rashidah; Rao, S. Venkat; Reddy, G. R.; Dechamma, H J; Suryanarayana, V. V. S.

doi:10.4149/av_2012_02_91

Cited by 14 publications

(8 citation statements)

References 40 publications

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“…The expression of subunit vaccines for animal viral diseases, such as avian influenza [98,161], foot-and-mouth disease (FMD) [100,101,102], and diarrhea [123,126,127], which are considered to be the most important causes of economic losses in plants, has been frequently reported. The commercialization of veterinary vaccine is relatively easy compared with that of human vaccines.…”

Section: Studies On Plant Vaccinesmentioning

confidence: 99%

The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B

Joung

Park

Moon

et al. 2016

IJMS

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Disease prevention through vaccination is considered to be the greatest contribution to public health over the past century. Every year more than 100 million children are vaccinated with the standard World Health Organization (WHO)-recommended vaccines including hepatitis B (HepB). HepB is the most serious type of liver infection caused by the hepatitis B virus (HBV), however, it can be prevented by currently available recombinant vaccine, which has an excellent record of safety and effectiveness. To date, recombinant vaccines are produced in many systems of bacteria, yeast, insect, and mammalian and plant cells. Among these platforms, the use of plant cells has received considerable attention in terms of intrinsic safety, scalability, and appropriate modification of target proteins. Research groups worldwide have attempted to develop more efficacious plant-derived vaccines for over 30 diseases, most frequently HepB and influenza. More inspiring, approximately 12 plant-made antigens have already been tested in clinical trials, with successful outcomes. In this study, the latest information from the last 10 years on plant-derived antigens, especially hepatitis B surface antigen, approaches are reviewed and breakthroughs regarding the weak points are also discussed.

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Section: Studies On Plant Vaccinesmentioning

confidence: 99%

The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B

Joung

Park

Moon

et al. 2016

IJMS

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“…This is a major challenge in livestock economy by reducing milk and meat production (Ruiz et al, 2015). Rao et al (2012) produced a bivalent vaccine against footand-mouth diseases expressing VP1 structural protein from two serotypes A and O. Oral feeding of pig with transgenic plants produced specific humoral immune response.…”

Section: Oral Vaccines Against Nonzoonotic Animal Diseasesmentioning

confidence: 99%

“…Oral feeding of pig with transgenic plants produced specific humoral immune response. Sera from immunized pigs when challenged with FMDV neutralized the virus with no cytopathic effect on BHK‐21 cells (Rao et al ., ). In another approach, VP1 protein was expressed in tobacco chloroplasts (Lentz et al ., ).…”

Section: Introductionmentioning

confidence: 97%

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Plant‐based oral vaccines against zoonotic and non‐zoonotic diseases

Shahid

Daniell

2016

Plant Biotechnology Journal

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SummaryThe shared diseases between animals and humans are known as zoonotic diseases and spread infectious diseases among humans. Zoonotic diseases are not only a major burden to livestock industry but also threaten humans accounting for >60% cases of human illness. About 75% of emerging infectious diseases in humans have been reported to originate from zoonotic pathogens. Because antibiotics are frequently used to protect livestock from bacterial diseases, the development of antibiotic‐resistant strains of epidemic and zoonotic pathogens is now a major concern. Live attenuated and killed vaccines are the only option to control these infectious diseases and this approach has been used since 1890. However, major problems with this approach include high cost and injectable vaccines is impractical for >20 billion poultry animals or fish in aquaculture. Plants offer an attractive and affordable platform for vaccines against animal diseases because of their low cost, and they are free of attenuated pathogens and cold chain requirement. Therefore, several plant‐based vaccines against human and animals diseases have been developed recently that undergo clinical and regulatory approval. Plant‐based vaccines serve as ideal booster vaccines that could eliminate multiple boosters of attenuated bacteria or viruses, but requirement of injectable priming with adjuvant is a current limitation. So, new approaches like oral vaccines are needed to overcome this challenge. In this review, we discuss the progress made in plant‐based vaccines against zoonotic or other animal diseases and future challenges in advancing this field.

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“…More recently, Rao et al . () reported the development of a bivalent vaccine with tandem‐linked VP1 proteins of two serotypes, A and O, present in a transgenic forage crop Crotalaria juncea . The authors tested this bivalent FMD vaccine in guinea pigs, which were immunized with leaf‐extracted proteins or oral fed with leaves of the transgenic plants.…”

Section: Foot‐and‐mouth Disease Virusmentioning

confidence: 99%

Plant‐produced viral bovine vaccines: what happened during the last 10 years?

Ruiz

Mozgovoj

Santos

et al. 2015

Plant Biotechnology Journal

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SummaryVaccination has proved to be an efficient strategy to deal with viral infections in both human and animal species. However, protection of cattle against viral infections is still a major concern in veterinary science. During the last two decades, the development of efficient plant-based expression strategies for recombinant proteins prompted the application of this methodology for veterinary vaccine purposes. The main goals of viral bovine vaccines are to improve the health and welfare of cattle and increase the production of livestock, in a cost-effective manner. This review explores some of the more prominent recent advances in plant-made viral bovine vaccines against foot-and-mouth disease virus (FMDV), bovine rotavirus (BRV), bovine viral diarrhoea virus (BVDV), bluetongue virus (BTV) and bovine papillomavirus (BPV), some of which are considered to be the most important viral causative agents of economic loss in cattle production.

show abstract

Expression of VP1 protein of serotype A and O of foot-and-mouth disease virus in transgenic sunnhemp plants and its immunogenicity for guinea pigs

Cited by 14 publications

References 40 publications

The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B

The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B

Plant‐based oral vaccines against zoonotic and non‐zoonotic diseases

Plant‐produced viral bovine vaccines: what happened during the last 10 years?

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