Expression of zebrafish <i>ROR alpha</i> gene in cerebellar‐like structures

Katsuyama, Yu; Oomiya, Yoshihiro; Dekimoto, Hideyuki; Motooka, Eriko; Takano, Ai; Kikkawa, Satoshi; Hibi, Masahiko; Terashima, Toshio

doi:10.1002/dvdy.21275

Cited by 22 publications

(26 citation statements)

References 48 publications

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“…However, no isoform for these four genes were detected although RORa and RORg gene generate four and two isoforms in human, respectively [19]. In agreement with two RORa paralogues in grass carp, two RORa genes (also named RORa1 and RORa2) have been identified from zebrafish genome [14]. Although only one zebrafish RORg has been reported [13], another zebrafish RORg sequence can be found from NCBI database (GenBank ID: XM_685651).…”

Section: Discussionmentioning

confidence: 80%

“…Moreover, zebrafish RORa1 (also named RORA by Flores et al) is conserved in syntenic chromosomal relationships when compared with human RORa [13,14]. Similarly, a conserved syntenic relationship between zebrafish RORg1 and human RORg has been established.…”

Section: Discussionmentioning

confidence: 89%

“…In teleost, only zebrafish ROR genes, including RORa, RORb and RORg, have been identified [13] and their expression patterns in embryonic development have also been investigated [13,14]. However, the roles of RORs in fish immunity and their regulation in fish are still unknown.…”

Section: Introductionmentioning

confidence: 97%

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Molecular evidence for the involvement of RORα and RORγ in immune response in teleost

Du¹,

Yang²,

Yang³

et al. 2012

Fish & Shellfish Immunology

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 89%

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Molecular evidence for the involvement of RORα and RORγ in immune response in teleost

Du¹,

Yang²,

Yang³

et al. 2012

Fish & Shellfish Immunology

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“…About 100 genes were found upregulated or downregulated by at least twofold. Genes involved in the development of neurons and eyes, for instance, crx [30], rcv1 [31], neurod [32], vsx1 [33], rho [34], atoh2a [35] and rorab [36] were found downregulated (data not shown). Interestingly, the tumor suppressor p53 signaling pathway was found to be activated.…”

Section: Cdna Microarray and Real-time Pcr Analysis Revealed Specificmentioning

confidence: 96%

Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish

et al. 2009

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The Small ubiquitin-related modifier (SUMO) conjugation to a variety of proteins regulates diverse cellular processes, including transcription, cell cycle regulation and maintenance of genome integrity. To investigate in vivo biological function of SUMO paralogs, we inactivated them in the early development of zebrafish. While zebrafish embryos deficient for all three SUMO paralogs, as Ubc9-deficient ones, displayed severe defects, loss of individual SUMO paralog was compatible with a normal development. SUMO-deficient embryos can be rescued by a single human or zebrafish SUMO. While key structural basic lysine residues and N-terminal unstructured stretch of SUMO are critical for in vivo rescue, the consensus K11 sumoylation site of SUMO2 is dispensable, implying that chain formation on this potential site is unessential for normal development. Inactivation of all three SUMOs triggered p53-dependent apoptosis and further inactivation of p53 restored normal zebrafish development. Interestingly, we also demonstrate that the dominant negative truncated form of p53, Δ113p53, significantly blunts SUMO depletion-induced p53 activity in vivo. Taken together, our results suggest that SUMO paralogs are indispensable, but redundant, in the early development of zebrafish.

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“…5). In zebrafish, the crest cells in the MON, Type I neurons in the optic tectum, and Purkinje cells express parvalbumin 7, glutamate receptor delta 2 (grid2), and retinoidrelated orphan receptor alpha 2 (rora2); the granule cells in these cerebellum-like structure express vglut1 (Mikami et al, 2004;Katsuyama et al, 2007;Bae et al, 2009) [Fig. 5(A-D)].…”

Section: Cerebellum-like Structuresmentioning

confidence: 99%

Development of the cerebellum and cerebellar neural circuits

Hibi

Shimizu

2012

Developmental Neurobiology

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141

114

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The cerebellum, a structure derived from the dorsal part of the most anterior hindbrain, is important for integrating sensory perception and motor control. While the structure and development of the cerebellum have been analyzed most extensively in mammals,recent studies have shown that the anatomy and development of the cerebellum is conserved between mammals and bony fish (teleost) species, including zebrafish. In the mammalian and teleost cerebellum,Purkinje and granule cells serve, respectively, as the major GABAergic and glutamatergic neurons. Purkinje cells originate in the ventricular zone (VZ), and receive inputs from climbing fibers. Granule cells originate in the upper rhombic lip (URL) and receive inputs from mossy fibers. Thus, the teleost cerebellum shares many features with the cerebellum of other vertebrates, and isa good model system for studying cerebellar function and development. The teleost cerebellum also has features that are specific to teleosts or have not been elucidated in mammals, including eurydendroid cells and adult neurogenesis. Furthermore, the neural circuitry in part of the optic tectum and the dorsal hindbrain closely resembles the circuitry of the teleost cerebellum; hence,these are called cerebellum-like structures. Here we describe the anatomy and development of cerebellar neurons and their circuitry, and discuss the possible roles of the cerebellum and cerebellum-like structures in behavior and higher cognitive functions. We also consider the potential use of genetics and novel techniques for studying the cerebellum in zebrafish.

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Expression of zebrafish ROR alpha gene in cerebellar‐like structures

Cited by 22 publications

References 48 publications

Molecular evidence for the involvement of RORα and RORγ in immune response in teleost

Molecular evidence for the involvement of RORα and RORγ in immune response in teleost

Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish

Development of the cerebellum and cerebellar neural circuits

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