2010
DOI: 10.1111/j.1398-9995.2010.02484.x
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Expression of α-defensin 1-3 in T cells from severe cutaneous drug-induced hypersensitivity reactions

Abstract: Upregulation of innate immune molecules such as α-defensins 1-3 in T cells from patients with SJS/TEN may be involved in the etiopathology of these life-threatening diseases induced by medications.

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Cited by 38 publications
(24 citation statements)
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“…DEFA1-3 are known to be significantly higher in T cells from peripheral blood and blister fluid in Stevens-Johnson syndrome/toxic epidermal necrolysis patients, where cytotoxic T cells are the main effector cells. 30 Our study confirms findings of previous microarray and cell culture studies that increased adipogenesis occur in active TO. 6,34,35 A group of genes involved in fatty acid and cholesterol synthesis was upregulated in our study including SREBF1, SCD, FADS1, and SCDP1.…”
Section: Discussionsupporting
confidence: 82%
See 1 more Smart Citation
“…DEFA1-3 are known to be significantly higher in T cells from peripheral blood and blister fluid in Stevens-Johnson syndrome/toxic epidermal necrolysis patients, where cytotoxic T cells are the main effector cells. 30 Our study confirms findings of previous microarray and cell culture studies that increased adipogenesis occur in active TO. 6,34,35 A group of genes involved in fatty acid and cholesterol synthesis was upregulated in our study including SREBF1, SCD, FADS1, and SCDP1.…”
Section: Discussionsupporting
confidence: 82%
“…There is considerable evidence that a-defensins are part of the innate immunity derived from neutrophils and monocytes. [28][29][30] a-defensins are involved in the inflammatory response as a chemotactic factor for neutrophils, monocytes, and T cells and promote adaptive immune responses. Conversely, a-defensins also reduces inflammatory injury through inhibiting lipopolysaccharide-mediated responses, and inhibiting proinflammatory cytokine secretion by macrophages.…”
Section: Discussionmentioning
confidence: 99%
“…Other SNPs with functional effects can be found in these genes [137], and next-generation sequencing studies in patients with hypersensitivity to NSAIDs are ongoing. Systems biology is a powerful instrument for integrating data from various studies that will shed new light on the mechanisms underlying drug hypersensitivity [130][131][132][133][134][135][136][137][138][139][140].…”
Section: Further Approaches For Deciphering Dhrsmentioning
confidence: 99%
“…The expression of different cytokines, chemokines, transcription factors or cytotoxic proteins can also be determined by real-time RT-PCR in both peripheral blood and skin samples [27], allowing us to further elucidate the underlying mechanisms, and the information gained from this process could then help us look for further diagnostic markers. ELISA can also be used to quantify the levels of cytokines, chemokines and cytotoxic proteins in peripheral blood serum or blister fluid [83] (summary in TABLE 1). The presence of CD4 + T lymphocytes in peripheral blood and the skin is characteristic of MPE and AGEP [10,84], whereas CD8 + T lymphocytes are mainly involved in FDE [37] and TEN [59].…”
Section: Identification Of the Clinical Entitymentioning
confidence: 99%