Expression of α-methyl coenzyme A racemase and p16 in colorectal adenoma and adenocarcinoma

Atef, Aliaa; Bedeer, Asmaa E.

doi:10.1097/01.xej.0000484374.45600.32

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…These previous studies were in accordance with Kuefer et al [34], Atef and Bedeer [35] and Adil et al [36] who demonstrated high AMACR expression in well to moderately differentiated CRCs and weak expression in poorly/anaplastic CRCs. Their data also suggested that AMACR expression can be a marker of tumor differentiation.…”

Section: Fig 6 Correlations Between Amacr Cyclin D1 and Ki67 Expressi...supporting

confidence: 91%

Does AMACR and Cyclin D1 Immunohistochemical Expression Vary on Comparing Mismatch Repair Proficient Versus Deficient Colorectal Carcinomas?

El-Guindy,

Hasby,

Atef

et al. 2023

JCTI

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Aim of Study: AMACR & Cyclin D1 expression in relation to different clinicopathological features was compared in MMR proficient versus deficient CRC subgroups. Methodology: MLH1 & MSH2 immunostaining was used to sort studied carcinomas. AMACR, cyclin D1 & ki67 expression was evaluated in neoplastic & non-neoplastic lesions too. Results: Of studied carcinomas, 40% were MMR proficient & 60% were MMR deficient. Low AMACR expression was detected in 50% & 66.7% of MMR proficient & deficient subgroups respectively. Cyclin D1 displayed high expression in 66.7% of MMR proficient & low expression in 53.3% of MMR deficient subgroups. AMACR is significantly related to gender, grade, extracellular mucin and dirty necrosis in MMR deficient while only to circumscription in MMR proficient subgroups. Cyclin D1 associated significantly with location, gross features, histologic type, pT, and pN in MMR proficient, and with location, histologic type, pT, pN, tumor stage, extracellular mucin, buds and dirty necrosis in MMR deficient subgroups. Correlations between AMACR and both cyclin D1 and Ki67 expression was significant in MMR deficient but were insignificant in MMR proficient subgroups. In both subgroups, the correlation between cyclin D1 and Ki67 expression was significant. Conclusion: AMACR and cyclin D1 seem to have a role in CRC carcinogenesis & genomic status influences their expression.

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Section: Fig 6 Correlations Between Amacr Cyclin D1 and Ki67 Expressi...supporting

confidence: 91%

Does AMACR and Cyclin D1 Immunohistochemical Expression Vary on Comparing Mismatch Repair Proficient Versus Deficient Colorectal Carcinomas?

El-Guindy,

Hasby,

Atef

et al. 2023

JCTI

View full text Add to dashboard Cite

show abstract

“…P16 is a tumor suppressor gene with function in cell cycle regulation [13][14][15][16][17]. A study performed by Atef et al (2016) showed that p16 expression was higher in colorectal adenoma than in colorectal carcinoma (72% versus 22.5%), which has supported the statement that gene inactivation or loss plays a crucial part in the carcinogenesis process [21]. However, in the analysis performed by Al-Ahwal et al (2016), immunoexpression of the gene was slightly higher in colorectal carcinomas, compared to adenomas and normal mucosa, suggesting that the absence of p16 is a sign of the benign course of the adenoma and a key factor in monitoring the progression towards malignancy [13].…”

Section:  Discussionmentioning

confidence: 99%

Squamous metaplasia within a sigmoid adenoma. A rare feature

Tîrcol

Ghidersa

Negreanu³

et al. 2020

Rom J Morphol Embryol

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Squamous metaplasia occurring within a colorectal polyp is a rare finding, having a reported incidence of approximately 0.44%. The origin of the squamous cells in this type of setting is uncertain (mechanical irritation and chronic inflammation are potential predisposing factors). It has been implied that the significance of squamous metaplasia in colorectal adenomas is that of a preneoplastic lesion for squamous cell and adenosquamous carcinoma, however the evidence to support this statement is scarce. We present a case of a large tubulovillous adenoma located in the sigmoid, with low-grade dysplasia and multiple foci of p16-positive immunoexpression squamous metaplasia in a 54-year-old Caucasian male, presenting with rectal bleeding.

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Expression of α-methyl coenzyme A racemase and p16 in colorectal adenoma and adenocarcinoma

Cited by 2 publications

References 26 publications

Does AMACR and Cyclin D1 Immunohistochemical Expression Vary on Comparing Mismatch Repair Proficient Versus Deficient Colorectal Carcinomas?

Does AMACR and Cyclin D1 Immunohistochemical Expression Vary on Comparing Mismatch Repair Proficient Versus Deficient Colorectal Carcinomas?

Squamous metaplasia within a sigmoid adenoma. A rare feature

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