Expression ofMUC2 gene in gastric regenerative, metaplastic, and neoplastic epithelia

Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa

“…Conclusions. We report here, for the first time, that CDX2 is expressed in patients with Barrett's epithelium and inflammatory in Paneth's cells; and mucus-secreting goblet cell-mucin marker (MUC2), 16,17 are associated with gastric and esophageal intestinal metaplasia.…”

Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia

“…[1][2][3][4] The CDX1/2 protein is predominantly expressed in the intestine and colon, but not in the normal epithelium of the stomach, through adulthood in humans and mice. [5][6][7] Many gene products, such as the intestinal enzyme, intestinal-type alkaline phosphatase (ALP); 8,9 the well characterized brush-border enzyme, sucrase-isomaltase (SI); 9,10 human defensin-5 (HD), [11][12][13] which is expressed predominantly in Paneth's cells; and mucus-secreting goblet cell-mucin markers (MUC2), 14,15 are associated with gastric intestinal metaplasia.…”

Expression of resistin-like molecule beta in gastric cancer: its relationship with clinicopathological parameters and prognosis

“…Biological parameters are being utilized for their diagnostic and prognostic values in the management of gastric cancer patients. A series of studies indicate that mucin 2 (MUC2) and intestinal trefoil factor (ITF), both goblet cell-derived proteins, aberrantly express and serve as prognostic biomarkers in gastric cancer [2][3][4]. Alterations of MUC2 are considered to be relevant to the abnormal behavior of cancer cells, such as altered cell adhesion or metastasis, and to the avoidance of immunological defense [5].…”