Expression pattern of a newt Notch homologue in regenerating newt retina

Kaneko, Yuko; Hirota, Kiyonori; Matsumoto, Gen; Hanyu, Yoshiro

doi:10.1016/s0165-3806(01)00147-x

Cited by 15 publications

(12 citation statements)

References 31 publications

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“…The role of this pathway in RPE reprogramming remains unclear, but it has been found that intensification of its function correlates mainly with progression of cell proliferation rather than with initiation of reprogramming [22]. The Notch signaling pathway is also important for the initiation and early progression of newt RPE cell reprogramming [20,21]. It has been shown that Notch and its ligands are upregulated immediately after damage, which is usually regarded as a reliable indicator of regeneration in sensory systems [107].…”

Section: Transcription Factors and Signal Molecules Characteristicmentioning

confidence: 99%

“…Accumulated data on morphological and molecular features of native retinal pigment epithelium (RPE) cells and those at the beginning of natural reprogramming to neuronal and glial cells of regenerating retina [6,7,11,12,13,14,17,18,19,20,21,22,23,24]. ( A ) RPE cells (thin white arrows) in the RPE layer of the newt Pleurodeles waltl ; ( B ) RPE cell that left its layer and stays at the beginning of reprogramming (thick white arrow); Scale bar: 100 µm.…”

Section: Figurementioning

confidence: 99%

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Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela

Grigoryan

Markitantova

2016

Biomedicines

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Many regeneration processes in animals are based on the phenomenon of cell reprogramming followed by proliferation and differentiation in a different specialization direction. An insight into what makes natural (in vivo) cell reprogramming possible can help to solve a number of biomedical problems. In particular, the first problem is to reveal the intrinsic properties of the cells that are necessary and sufficient for reprogramming; the second, to evaluate these properties and, on this basis, to reveal potential endogenous sources for cell substitution in damaged tissues; and the third, to use the acquired data for developing approaches to in vitro cell reprogramming in order to obtain a cell reserve for damaged tissue repair. Normal cells of the retinal pigment epithelium (RPE) in newts (Urodela) can change their specialization and transform into retinal neurons and ganglion cells (i.e., actualize their retinogenic potential). Therefore, they can serve as a model that provides the possibility to identify factors of the initial competence of vertebrate cells for reprogramming in vivo. This review deals mainly with the endogenous properties of native newt RPE cells themselves and, to a lesser extent, with exogenous mechanisms regulating the process of reprogramming, which are actively discussed.

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Section: Transcription Factors and Signal Molecules Characteristicmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela

Grigoryan

Markitantova

2016

Biomedicines

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“…However, the detailed cellular and molecular events that drive this process still need to be clearly dissected. The field has taken some forward steps with the increase availability of tools, such as antibodies and cDNAs (Klein et al, 1990; Bugra et al, 1992; Negishi et al, 1992; Mitashov et al, 1995; Saito et al, 1994; Chiba et al, 1997; Cheon et al, 1998; Kaneko et al, 1999, 2001; Sakakibara et al, 2002). Further steps need to be taken to bring this field into the molecular age, including the use of new technology, such as morpholinos and RNAi to create knockdown animals (Heasman, 2002; Zhou et al, 2002), the use of viral vectors (Burns et al, 1994; Roy et al, 2000; Kumar et al, 2000) to bypass the production of transgenic animals (very difficult to produce in urodeles) by creating “on site transgenics,” or by the use of tissue/organ cultures that could be manipulated with the addition of key factors or genes (Ikegami et al, 2002).…”

Section: Retina Regenerationmentioning

confidence: 99%

Eye regeneration at the molecular age

Rio‐Tsonis

Tsonis

2003

Developmental Dynamics

160

114

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Eye tissues such as the lens and the retina possess remarkable regenerative abilities. In amphibians, a complete lens can be regenerated after lentectomy. The process is a classic example of transdifferentiation of one cell type to another. Likewise, retina can be regenerated, but the strategy used to replace the damaged retina differs, depending on the animal system and the age of the animal. Retina can be regenerated by transdifferentiation or by the use of stem cells. In this review, we present a synthesis on the regenerative capacity of eye tissues in different animals with emphasis on the strategy and the molecules involved. In addition, we stress the place of this field at the molecular age and the importance of the recent technologic advances. Developmental Dynamics 226:211-224, 2003.

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“…Newt retinal regeneration has been fully documented in numerous studies (Stone 1950a,b;Hasegawa 1958;Reyer 1971Reyer , 1977. Recent studies have also suggested that many common features exist between the development and regeneration of the retina in gene expression of several transcription factors necessary for ocular development (Kaneko et al 1999(Kaneko et al , 2001. The mode for cell-cell communication of RPE cells appears to alter during the early phase of regeneration (Haruta et al 2001;Umino & Saito 2002), suggesting that cell adhesion moleculemediated cell communication between RPE cells may play a role in regenerating events.…”

Section: Newt (Urodele) Retinal Regenerationmentioning

confidence: 99%

“…Newt retinal regeneration has been fully documented in numerous studies (Stone 1950a,b; Hasegawa 1958; Reyer 1971, 1977). Recent studies have also suggested that many common features exist between the development and regeneration of the retina in gene expression of several transcription factors necessary for ocular development (Kaneko et al . 1999, 2001).…”

Section: Amphibian Retinal Regenerationmentioning

confidence: 99%

Regeneration of the amphibian retina: Role of tissue interaction and related signaling molecules on RPE transdifferentiation

Araki

2007

Dev Growth Differ

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Regeneration of eye tissue is one of the classic subjects in developmental biology and it is now being vigorously studied to reveal the cellular and molecular mechanisms involved. Although many experimental animal models have been studied, there may be a common basic mechanism that governs retinal regeneration. This can also control ocular development, suggesting the existence of a common principle between the development and regeneration of eye tissues. This notion is now becoming more widely accepted by recent studies on the genetic regulation of ocular development. Retinal regeneration can take place in a variety of vertebrates including fish, amphibians and birds. The newt, however, has been considered to be the sole animal that can regenerate the whole retina after the complete removal of the retina. We recently discovered that the anuran amphibian also retains a similar ability in the mature stage, suggesting the possibility that such a potential could be found in other animal species. In the present review article, retinal regeneration of amphibians (the newt and Xenopus laevis) and avian embryos are described, with a particular focus on transdifferentiation of retinal pigmented epithelium. One of the recent progresses in this field is the availability of tissue culture methods to analyze the initial process of transdifferentiation, and this enables us to compare the proliferation and neural differentiation of retinal pigmented epithelial cells from various animal species under the same conditions. It was revealed that tissue interactions between the retinal pigmented epithelium and underlying connective tissues (the choroid) play a substantial role in transdifferentiation and that this is mediated by a diffusible signal such as fibroblast growth factor 2. We propose that tissue interaction, particularly mesenchyme-neuroepithelial interaction, is considered to play a fundamental role both in retinal development and regeneration.

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Expression pattern of a newt Notch homologue in regenerating newt retina

Cited by 15 publications

References 31 publications

Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela

Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela

Eye regeneration at the molecular age

Regeneration of the amphibian retina: Role of tissue interaction and related signaling molecules on RPE transdifferentiation

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