Expression pattern of estroprogestinic receptors in sinonasal inverted papilloma

Abstract

Inverted papilloma (IP) is a locally destructive, benign neoplasm of the nose and paranasal sinuses with a high tendency for recurrence, a significant potential for malignancy, and an etiology that today is still uncertain. The expression of hormonal receptors in neoplastic tissues has been the focus of intensive research for its potential diagnostic, prognostic, and therapeutic significance. The aim of this study was to assess the potential estroprogestinic receptor expression in patients undergoing sinus surgery for IP. A retrospective study was carried out, on surgical specimens of 73 patients who underwent endoscopic sinus surgery for first manifestation of sinonasal IP (primitive IP group) and in 21 subjects who had developed a recurrence (relapsed IP group). The results of the immunohistochemical analysis of the first group showed the absence of receptor expression for PGR in all cases analyzed and the presence of a low positivity for ER in 11 cases (P > 0.082). Similarly, in the second group the results showed a low presence of ER receptors in 3 of the 21 cases (P > 0.068), while there was no evidence of PGR receptors in the examined samples. In addition, in 11 of the cases only 3 were considered positive (27.2%) showing a recurrence during follow-up (P > 0.068).Our results suggest that the sinonasal IP is a benign tumor independent of estrogen and progesterone, and the receptors for these hormones are therefore unsuitable as predictors of relapse or possible prognostic indicators and therapeutic targets.

Rhinoplasty in Context of Head and Neck Malignancy

“…The endonasal approach involves the mobilization and repositioning of the septum, followed by the correction of the bone pyramid and cartilage with possible osteotomies and additional stabilization surgery of the septum, and finally the modification of the wing of the nose according to the esthetics of the new pyramid. The open approach on the other hand requires the exposure of the wing structures of the nose and the vestibule and of the cartilaginous spine with the mobilization and the repositioning of the septum and the correction of the osteocartilaginous pyramid for the reconstruction of the structure with the modification of the nasal wing [10][11][12].…”