Expression pattern of macrophage migration inhibitory factor during embryogenesis

Kobayashi, Shigetoshi; Satomura, Kimio; Levsky, Jeffrey M.; Sreenath, Taduru; Wistow, Graeme; Semba, Ichiro; Shum, Lillian; Slavkin, Harold C.; Kulkarni, Ashok B.

doi:10.1016/s0925-4773(99)00057-x

Cited by 33 publications

(25 citation statements)

References 8 publications

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“…It is almost ubiquitously expressed in the organs of the human and other mammals (9 -16), but its expression can vary markedly among cell types within each tissue. In many cases, MIF expression seems to be associated with differentiating and proliferating cells (12,16), but specific roles for MIF also have been proposed for differentiated physiologic systems as well.…”

Section: Resultsmentioning

confidence: 99%

Macrophage Migration Inhibitory Factor is a Constitutively Expressed Cytokine in the Human Adrenal Gland

Jian

Parker

2003

IUBMB Life

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SummaryMacrophage migration inhibitory factor (MIF) has been found to be widely expressed in many cell types throughout the body and appears to play several physiologic roles. We sought to determine the expression and cellular distribution of MIF in human fetal (HFA) and adult (HAA) adrenals. A single band of approximately 0.8 kb was revealed by northern blot hybridization using cDNA probes for MIF in total RNA extracts of both HFA and HAA tissues. Immunohistochemical analysis showed strong immunostaining for MIF in the broad fetal zone of the HFA and in both the zona glomerulosa and zona reticularis of HAA. The cells of the zona fasciculata of the HAA and of the neocortex of the HFA were only minimally, if at all, immunopositive for MIF and medullary elements were consistently negative for MIF. These results are indicative of local production of MIF in adrenocortical cells during intrauterine development and also in adulthood. The role of MIF in cortical cells of the human adrenal gland remains to be determined. IUBMB Life, 55: 155-158, 2003

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Section: Resultsmentioning

confidence: 99%

Macrophage Migration Inhibitory Factor is a Constitutively Expressed Cytokine in the Human Adrenal Gland

Jian

Parker

2003

IUBMB Life

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“…Such a role is supported by evidence from several earlier studies. For example, cytokines, including MIF, have been found in the developing CNS, eye and inner ear of Xenopus (Suzuki et al, 2004) and mouse (Kobayashi et al, 1999) and in the zebrafish eye (Ito et al, 2008) and ear (Holmes et al, 2011;Shen et al, 2012). MOs injected into one-cell Xenopus embryos resulted in the absence of a neuraxis (Suzuki et al, 2004), a phenotype that was rescued by concomitant injection of Mif RNAs.…”

Section: Research Article Development 139 (24)mentioning

confidence: 99%

Macrophage migration inhibitory factor acts as a neurotrophin in the developing inner ear

et al. 2012

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This study is the first to demonstrate that macrophage migration inhibitory factor (MIF), an immune system ‘inflammatory’ cytokine that is released by the developing otocyst, plays a role in regulating early innervation of the mouse and chick inner ear. We demonstrate that MIF is a major bioactive component of the previously uncharacterized otocyst-derived factor, which directs initial neurite outgrowth from the statoacoustic ganglion (SAG) to the developing inner ear. Recombinant MIF acts as a neurotrophin in promoting both SAG directional neurite outgrowth and neuronal survival and is expressed in both the developing and mature inner ear of chick and mouse. A MIF receptor, CD74, is found on both embryonic SAG neurons and adult mouse spiral ganglion neurons. Mif knockout mice are hearing impaired and demonstrate altered innervation to the organ of Corti, as well as fewer sensory hair cells. Furthermore, mouse embryonic stem cells become neuron-like when exposed to picomolar levels of MIF, suggesting the general importance of this cytokine in neural development.

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“…MIF is known to be expressed during embryogenesis, and MIF protein can be detected in the heart and the CNS from E10 onwards (33). MIF production in the developing lung has not been characterized previously, however.…”

Section: Mif Production In the Developing Lungmentioning

confidence: 99%

A Role for Macrophage Migration Inhibitory Factor in the Neonatal Respiratory Distress Syndrome

Kevill

Bhandari

Kettunen

et al. 2008

The Journal of Immunology

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Using a mouse model of neonatal respiratory distress syndrome (RDS), we demonstrate a central role for macrophage migration inhibitory factor (MIF) in lung maturation at the developmental stage when human neonates are most susceptible to RDS. We prematurely delivered mouse pups at embryonic day 18, during the early saccular stage of pulmonary development. Only 8% of the prematurely delivered pups genetically deficient in MIF survived 8 h vs 75% of wild-type controls (p < 0.001). This phenotype was corrected when pups of all genotypes were bred from dams heterozygote for MIF deficiency. Local production of MIF in the lung increased at embryonic day 18, continued until full-term at embryonic day 19.5, and decreased in adulthood, thus coinciding with this developmental window. The lungs of pups genetically deficient in MIF were less mature upon histological evaluation, and demonstrated lower levels of vascular endothelial growth factor and corticosterone – two factors that promote fetal lung maturation. In vitro studies support a role for MIF in surfactant production by pulmonary epithelial cells. In a cohort of human neonates with RDS, higher intrapulmonary MIF levels were associated with a lower likelihood of developing bronchopulmonary dysplasia, a sequelae of RDS (p < 0.03). This study demonstrates for the first time a role for MIF in lung maturation, and supports a protective role for MIF in newborn lung disease.

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Expression pattern of macrophage migration inhibitory factor during embryogenesis

Cited by 33 publications

References 8 publications

Macrophage Migration Inhibitory Factor is a Constitutively Expressed Cytokine in the Human Adrenal Gland

Macrophage Migration Inhibitory Factor is a Constitutively Expressed Cytokine in the Human Adrenal Gland

Macrophage migration inhibitory factor acts as a neurotrophin in the developing inner ear

A Role for Macrophage Migration Inhibitory Factor in the Neonatal Respiratory Distress Syndrome

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