2003
DOI: 10.1095/biolreprod.103.015933
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Expression Pattern of Metalloproteinases and Tissue Inhibitors of Matrix-Metalloproteinases in Cycling Human Endometrium1

Abstract: The cyclic growth, differentiation, and cell death of endometrium represents the most dynamic example of steroid-driven tissue turnover in human adults. Key effectors in these processes-matrix metalloproteinases (MMPs) and their specific inhibitors (TIMPs)-are regulated by ovarian steroids and, locally, by cytokines. We used reverse transcription-polymerase chain reaction to evaluate the expression of both transcriptionally regulated molecules such as estrogen receptor-alpha, progesterone receptor, and prolact… Show more

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Cited by 131 publications
(120 citation statements)
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“…The expression of TIMP-2 tended to decrease at the same time as an increase was seen in MMP-9 and -2 activities after endometritis was induced. This shows a different pattern of regulation to the human endometrium, where a fluctuation in MMPs is not met by a fluctuation in TIMP-2 activity during menstruation (Goffin et al 2003). …”
Section: Discussionmentioning
confidence: 93%
See 1 more Smart Citation
“…The expression of TIMP-2 tended to decrease at the same time as an increase was seen in MMP-9 and -2 activities after endometritis was induced. This shows a different pattern of regulation to the human endometrium, where a fluctuation in MMPs is not met by a fluctuation in TIMP-2 activity during menstruation (Goffin et al 2003). …”
Section: Discussionmentioning
confidence: 93%
“…This is not surprising as the equine oestrous cycle does not involve the same degree of remo-delling the human menstrual cycle, where increased MMP-9 activity is associated with menstruation (Goffin et al 2003).…”
Section: Discussionmentioning
confidence: 95%
“…Matrilysins, also called MMP-7 (matrilysin 1) and MMP-26 (matrilysin 2) proteases implicated in the substrate degradation of basement membranes, are involved in a variety of processes, such as cell proliferation, 22 apoptosis, 23 invasion, and metastasis. 14,[24][25][26] Matrilysins differ from other MMPs in their low molecular weight, by their lack of a C-terminal hemopexin domain common to other MMPs, 26,27 and their conspicuous expression in epithelial cells.…”
mentioning
confidence: 99%
“…14,[24][25][26] Matrilysins differ from other MMPs in their low molecular weight, by their lack of a C-terminal hemopexin domain common to other MMPs, 26,27 and their conspicuous expression in epithelial cells. 28,29 Despite reports describing the importance of matrilysins in normal glandular epithelium 22,25,29 as well as in malignant epithelial neoplasms, 24,28,29 to date, there are no studies on the expression of MMPs-7 and Ϫ26 in odontogenic lesions.…”
mentioning
confidence: 99%
“…Analysis was performed as described previously (Goffin et al, 2003) using RNeasy Protect Kit and QIAshredder Kit (QIAGEN Benelux, Venlo, Netherlands). On the basis of the results obtained, a suitable cell line to inoculate into athymic mice was chosen.…”
Section: Rt Pcr Analysismentioning
confidence: 99%