Expression Patterns of Kinin-Dependent Genes in Endometrial Cancer

Orchel, Joanna; Witek, Lukasz; Kimsa, Malgorzata W.; Strzałka‐Mrozik, Barbara; Kimsa, Magdalena C.; Olejek, Anita; Mazurek, Urszula

doi:10.1097/igc.0b013e318259d8da

Cited by 33 publications

(30 citation statements)

References 21 publications

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“…As an inflammatory mediator, bradykinin triggers kinin-activated pathways. These have been associated with EC and breast cancer progression, supporting the role of bradykinin in tumors originating from steroid sensitive tissues (39,40). Sulfated androgens were also higher in type I EC cases, consistent with the reported implication of sulfated steroids in this histotype (8,(41)(42)(43)(44).…”

Section: Discussionsupporting

confidence: 73%

Identification of metabolomic biomarkers for endometrial cancer and its recurrence after surgery in postmenopausal women

Audet-Delage

Villeneuve

Grégoire

et al. 2019

Drug Metabolism and Pharmacokinetics

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Section: Discussionsupporting

confidence: 73%

Identification of metabolomic biomarkers for endometrial cancer and its recurrence after surgery in postmenopausal women

Audet-Delage

Villeneuve

Grégoire

et al. 2019

Drug Metabolism and Pharmacokinetics

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“…Cell Cycle, Apoptosis, Transcription and Developmental-related categories were enriched in the differentially expressed genes of LN (+) vs. LN (-), as in our study. The same categories were enriched in cervical cancer studies [ 4 , 5 , 37 , 38 ] and endometrial study [ 39 ], either in gene ontology analysis of biological functions or in pathway analysis. By extending our findings to other gynecological cancer studies, it was made obvious that there were common features among endometrial, vulvar and cervical cancer cells in terms of biological functions and pathway deregulation.…”

Section: Resultsmentioning

confidence: 99%

Profiling of Discrete Gynecological Cancers Reveals Novel Transcriptional Modules and Common Features Shared by Other Cancer Types and Embryonic Stem Cells

et al. 2015

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Studies on individual types of gynecological cancers (GCs), utilizing novel expression technologies, have revealed specific pathogenetic patterns and gene markers for cervical (CC), endometrial (EC) and vulvar cancer (VC). Although the clinical phenotypes of the three types of gynecological cancers are discrete, the fact they originate from a common embryological origin, has led to the hypothesis that they might share common features reflecting regression to early embryogenesis. To address this question, we performed a comprehensive comparative analysis of their profiles. Our data identified both common features (pathways and networks) and novel distinct modules controlling the same deregulated biological processes in all three types. Specifically, four novel transcriptional modules were discovered regulating cell cycle and apoptosis. Integration and comparison of our data with other databases, led to the identification of common features among cancer types, embryonic stem (ES) cells and the newly discovered cell population of squamocolumnar (SC) junction of the cervix, considered to host the early cancer events. Conclusively, these data lead us to propose the presence of common features among gynecological cancers, other types of cancers, ES cells and the pre-malignant SC junction cells, where the novel E2F/NFY and MAX/CEBP modules play an important role for the pathogenesis of gynecological carcinomas.

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“…In the current study, cAMP-dependent protein kinase catalytic beta subunit (PRKACB) was selected as the theoretical target gene of miR-384 by the analysis of prediction software. PRKACB gene has been identified to be an important oncogene in cancer progression, especially in the progression of endocrine cancers by modulating cAMP signaling activity [33,34]. Moreover, it was recently found that miR-302a-3p suppresses hepatocellular carcinoma progression by targeting the 3′-UTR of PRKACB gene [35].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-384 Inhibits the Progression of Papillary Thyroid Cancer by Targeting PRKACB

Wang

Zhou

et al. 2020

BioMed Research International

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Background. Growing evidence shows that dysregulation of miRNAs plays a significant role in papillary thyroid cancer (PTC) tumorigenesis and development. The abnormal expression of miR-384 has been acknowledged in the proliferation or metastasis of some cancers. However, the function and the underlying mechanism of miR-384 in PTC progression remain largely unknown. Methods. Real-time PCR was conducted to detect miR-384 expression in 58 cases of PTC and their adjacent noncancerous tissues. MTT, soft agar assay Transwell assay, and wound-healing assay were carried out to explore the biological function of miR-384 in PTC cell lines of BCPAP and K1. Bioinformatics analysis, dual-luciferase reporter assay, western blot, and functional complementation analysis were conducted to explore the target gene of miR-384. Moreover, Spearman’s correlation analysis was conducted to reveal the correlation between miR-384 and PRKACB mRNA in PTC. Results. The expression of miR-384 decreased obviously in PTC, especially in the tumors with lymph node metastasis or larger tumor size. The ectopic upregulation of miR-384 significantly suppressed PTC progression, and the inhibition of miR-384 had the opposite effects. Moreover, PRKACB gene was confirmed as the target of miR-384. Conclusion. The study suggests that miR-384 serves as a tumor suppressor in PTC progression by directly targeting the 3′-UTR of PRKACB gene.

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Expression Patterns of Kinin-Dependent Genes in Endometrial Cancer

Abstract: The expression changes in kinin-dependent genes might cause disturbance in the underlying biological processes, which could be important for the pathogenesis of endometrial cancer. This will eventually help to improve treatment strategies for patients with endometrial cancer in the future.

Cited by 33 publications

References 21 publications

Identification of metabolomic biomarkers for endometrial cancer and its recurrence after surgery in postmenopausal women

Identification of metabolomic biomarkers for endometrial cancer and its recurrence after surgery in postmenopausal women

Profiling of Discrete Gynecological Cancers Reveals Novel Transcriptional Modules and Common Features Shared by Other Cancer Types and Embryonic Stem Cells

MicroRNA-384 Inhibits the Progression of Papillary Thyroid Cancer by Targeting PRKACB

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