Expression profile of E‐cadherin, estrogen receptors, and P53 in early‐onset gastric cancers

Zhang, Fan; Xu, Yuanyuan; Shi, Jiong; Lan, Xing; Zou, Xiaoping; Wang, Lei; Huang, Qin

doi:10.1002/cam4.931

Cited by 28 publications

(32 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Enormous cohort study confirmed ERα and ERβ existence in both gastric tssue either cancerous or non-cancer [53] . Recently, Fan Zhou et al confirmed the presence of ERα and ERβ in stomach by immunohistochemistry [54] . Estrogen acts on intracellular receptor (ERs), which mediates its cellular actions that are found in gastric tissue (both cancerous and non-cancerous) and regulates its action .…”

Section: Discussionmentioning

confidence: 95%

Histological and Biochemical Study on the Estrogen Role in Indomethacin-induced Gastric Ulcer of Menopausal Rats

Mohamed

Ahmed

Shalaby

et al. 2019

Journal of Medical Histology

View full text Add to dashboard Cite

Background: Estrogen is a principal female sex hormone that originally characterized by its importance in sexual growth and reproduction. Nevertheless, emergent evidence proposes clinical relationship between estrogen/ estrogen receptors and gastric diseases. This association is definitely under several investigated topics. Aim: The current study designed to explore exogenous estrogen effect on indomethacin-induced gastric ulcers in postmenopausal female rats. Matrial and methods: Twenty-four female rats (200 ± 20 gram BW) were allocated randomly into four groups; control, ulcer-induced, ranitidine-treated and (ranitidine&estradiol velerate) combined-treated group. Animal in all group except control subjected to ovariectomy to assimilate menopausal condition. At end of the experiment, the stomach fundus examined macroscopically to assess the ulcer severity and ulcer score in different groups. Histopatholgical and biochemical evaluation also were performed and all results were statistically analyzed. Results: Indomethacin-induced gastric ulcer in ovariectomized rats showed destroyed fundic mucosa and mucus layer, increase oxidative stress markers, inflammatory mediators and myeloperoxidase. Treatment with ranitidine attenuated the histological and biochemical changes but within limits. Better improvement was accomplished when ranitidine combined with estrogen. Conclusion: The postmenopausal women should be supplemented with estrogen not only to control menopausal symptoms but also to protect and maintain gastric mucosal integrity.

show abstract

Section: Discussionmentioning

confidence: 95%

Histological and Biochemical Study on the Estrogen Role in Indomethacin-induced Gastric Ulcer of Menopausal Rats

Mohamed

Ahmed

Shalaby

et al. 2019

Journal of Medical Histology

View full text Add to dashboard Cite

show abstract

“…Therefore, it can be detected by immunohistochemical staining. Several studies have reported that overexpression of p53 were independent risk factors for EGC patients [35,36] . Ki67 is a nuclear proliferation-associated antigen, which encodes two protein isoforms with molecular weights of 345 and 395 kDa.…”

Section: Discussionmentioning

confidence: 99%

Recurrence in node-negative advanced gastric cancer with novel clinical and pathologic findings

Chen¹,

Xu²,

J³

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Background Node-negative gastric cancer patients carry a better prognosis than node-positive. However, a subset of these patients eventually died due to the high recurrence rate of recurrence. This study investigated the clinic-pathologic factors for recurrent patterns and prognosis. Methods The detailed medical records of 947 gastric cancer patients who underwent gastrectomy from the prospectively collected database of the Gastrointestinal Surgery Department of the First Affiliated Hospital of Zhejiang Chinese Medical University From January 2012 to December 2014 were analyzed retrospectively. Results Tumor size, tumor invasion, histological grading were the predictive factors for locoregional recurrence. Tumor invasion, histological grading, Lauren type and lymphatic vessel invasion resulted significantly in predicting peritoneal recurrence. Two parameters, tumor invasion and lymphatic vessel invasion, were significantly associated with hematogenous spread. The combinatorial biomarker of positive for both Ki67 and P53 was significantly associated with recurrence-free survival (RFS) (P = 0.037). Histological grading (P = 0.020), tumor invasion (P = 0.007) and lymphatic vessel invasion (P = 0.012) were independent factors related to overall survival (OS) in node-negative advanced gastric cancer patients. Conclusion The reported clinicopathologic factors for different recurrence patterns and the prognostic factors of RFS and OS should be considered to guide clinicians choose appropriate postoperative treatment strategy and construct individual follow-up schedule to improve prognosis of node-negative gastric cancer.

show abstract

“…From an immunohistochemical point of view, the p53 protein, encoded by a tumor suppressor gene located on the short arm of chromosome 17, is involved in different cell functions, including apoptosis and cell cycle regulation[ 16 ]. This protein is usually poorly expressed in normal cells, but overexpressed and/or mutated in a number of human malignancies[ 17 ]; overexpression of p53 generally reflects an underlying mutation(s) in the p53 gene[ 16 ]. A correlation among high protein levels, older age, advanced stage, and poor prognosis has been shown for colorectal, breast, and lung carcinoma[ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Recurrence in node-negative advanced gastric cancer: Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series

Baiocchi

Molfino

Baronchelli

et al. 2017

WJG

View full text Add to dashboard Cite

AIMTo analyze the clinicopathological characteristics of patients with both node-negative gastric carcinoma and diagnosis of recurrence during follow-up.METHODSWe enrolled 41 patients treated with curative gastrectomy for pT2-4aN0 gastric carcinoma between 1992 and 2010, who developed recurrence (Group 1). We retrospectively selected this group from the prospectively collected database of 4 centers belonging to the Italian Research Group for Gastric Cancer, and compared them with 437 pT2-4aN0 patients without recurrence (Group 2). We analyzed lymphatic embolization, microvascular infiltration, perineural infiltration, and immunohistochemical determination of p53, Ki67, and HER2 in Group 1 and in a subgroup of Group 2 (Group 2bis) of 41 cases matched with Group 1 according to demographic and pathological characteristics.RESULTST4a stage and diffuse histotype were associated with recurrence in the group of pN0 patients. In-depth pathological analysis of two homogenous groups of pN0 patients, with and without recurrence during long-term follow-up (groups 1 and 2bis), revealed two striking patterns: lymphatic embolization and perineural infiltration (two parameters that pathologists can easily report), and p53 and Ki67, represent significant factors for recurrence.CONCLUSIONThe reported pathological features should be considered predictive factors for recurrence and could be useful to stratify node-negative gastric cancer patients for adjuvant treatment and tailored follow-up.

show abstract

Expression profile of E‐cadherin, estrogen receptors, and P53 in early‐onset gastric cancers

Cited by 28 publications

References 34 publications

Histological and Biochemical Study on the Estrogen Role in Indomethacin-induced Gastric Ulcer of Menopausal Rats

Histological and Biochemical Study on the Estrogen Role in Indomethacin-induced Gastric Ulcer of Menopausal Rats

Recurrence in node-negative advanced gastric cancer with novel clinical and pathologic findings

Recurrence in node-negative advanced gastric cancer: Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series

Contact Info

Product

Resources

About