Expression profile of interferon tau–stimulated genes in ovine peripheral blood leukocytes during embryonic death

Köse, Mehmet; Kaya, Muhsin; Aydılek, Nurettın; Küçükaslan, İbrahim; Bayril, Tahir; Bademkiran, Servet; Kıyma, Z.; Özyurtlu, Nihat; Kayış, Seyit Ali; Güzeloğlu, Aydın; Atlı, Mehmet Osman

doi:10.1016/j.theriogenology.2015.11.032

Cited by 30 publications

(14 citation statements)

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“…In addition to serving as a chaperone protein for the transport of GPCRs (Behrens et al, 2006;Décaillot et al, 2008;Gifford et al, 2008), RTP4 has been shown to have other physiologic roles. RTP4 is one of the interferon-stimulated genes increased in peripheral blood leukocytes after pregnancy and, thus, could be used as a marker of pregnancy, particularly in rodents (Gifford et al, 2008;Ribeiro et al, 2014;Kose et al, 2016;Sinedino et al, 2017). In addition, RTP4 plays an important role as a marker of disease incidence in conditions such as hypertension in type 2 diabetic patients, Q-fever, interferon-induced depression, HER2(1) breast cancer, and virus infection (Laurin et al, 2013;Mehraj et al, 2013;Davenport et al, 2015;Hoyo-Becerra et al, 2015;Radkowski et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Regulation of an Opioid Receptor Chaperone Protein, RTP4, by Morphine

et al. 2018

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Signaling by classic analgesics, such as morphine, is governed primarily by the relative abundance of opioid receptors at the cell surface, and this is regulated by receptor delivery to, and retrieval from, the plasma membrane. Although retrieval mechanisms, such as receptor endocytosis, have been extensively investigated, fewer studies have explored mechanisms of receptor maturation and delivery to the plasma membrane. A previous study implicated receptor transporter proteins (RTPs) in the latter process. Since not much is known about regulation of RTP expression, we initiated studies examining the effect of chronic morphine administration on the levels of RTPs in the brain. Among the four RTPs, we detected selective and region-specific changes in RTP4 expression; RTP4 mRNA is significantly upregulated in the hypothalamus compared with other brain regions. We examined whether increased RTP4 expression impacted receptor protein levels and found a significant increase in the abundance of mu opioid receptors (MOPrs) but not other related G protein-coupled receptors (GPCRs, such as delta opioid, CB 1 cannabinoid, or D 2 dopamine receptors) in hypothalamic membranes from animals chronically treated with morphine. Next, we used a cell culture system to show that RTP4 expression is necessary and sufficient for regulating opioid receptor abundance at the cell surface. Interestingly, selective MOPr-mediated increase in RTP4 expression leads to increases in cell surface levels of MOPr-delta opioid receptor heteromers, and this increase is significantly attenuated by RTP4 small interfering RNA. Together, these results suggest that RTP4 expression is regulated by chronic morphine administration, and this, in turn, regulates opioid receptor cell surface levels and function.

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Section: Discussionmentioning

confidence: 99%

Regulation of an Opioid Receptor Chaperone Protein, RTP4, by Morphine

et al. 2018

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“…In another study in pregnant ewes, the MX1 transcript levels was significantly upturned on days 15, remained consistent till days 23 and then declined on days 25-30 28 . Furthermore, the MX1 expression was also noted to be elevated on days 15 in PBMCs of pregnant ewe 32 and cow 33 .…”

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confidence: 85%

Interferon Stimulated Genes (Isgs): Novel Pregnancy Specific Biomarker In Buffaloes (Bubalus bubalis

Sarkar¹

2018

J Immunological Sci

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Early embryonic mortality (EEM) has been shown to be the prime cause of pregnancy failure in domestic species incurring severe economic losses in terms of milk production in dairy cows in most of the tropical countries including India. Despite of the availability of various diagnosis methods for the pregnancy detection the domestic animals are still prone to reproductive failure before the onset of implantation. Recently, a group of genes called as interferon stimulated genes (ISG) have been shown to be expressed during peri-implanation period which could serve as a potential diagnostic marker for early detection of pregnancy in domestic species. The present mini review highlights the differential expression dynamics of interferon stimulated genes (ISG) during early pregnancy period in buffalo.

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“…In this same way, most embryo losses happen before day 18 of pregnancy (Diskin and Sreenan, 1980;Wiltbank et al, 2016), but an earlier secretion of IFN-τ could have occurred in animals that underwent embryo loss, increasing the false positive rate. When pregnant, non-pregnant and embryo death (by PGF2α on day 18 of pregnancy) were evaluated in ewes, no difference was found for embryo death and pregnant ewes on ISG expression on day 21 and 23 post-mating (Kose et al, 2016). Another important point to be considered is the false negative rate, which must be null for a pregnancy diagnosis.…”

Section: Understanding the Conceptus-modulated Immune System For Applied Purposesmentioning

confidence: 99%

Conceptus-modulated innate immune function during early pregnancy in ruminants: a review

et al. 2021

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This review focuses on the innate immune events modulated by conceptus signaling during early pregnancy in ruminants. Interferon-tau (IFN-τ) plays a role in the recognition of pregnancy in ruminants, which involves more than the inhibition of luteolytic pulses of PGF2α to maintain corpus luteum function. For successful pregnancy establishment, the allogenic conceptus needs to prevent rejection by the female. Therefore, IFN-τ exerts paracrine and endocrine actions to regulate the innate immune system and prevent conceptus rejection. Additionally, other immune regulators work in parallel with IFN-τ, such as the pattern recognition receptors (PRR). These receptors are activated during viral and bacterial infections and in early pregnancy, but it remains unknown whether PPR expression and function are controlled by IFN-τ. Therefore, this review focuses on the main components of the innate immune response that are involved with early pregnancy and their importance to avoid conceptus rejection.

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Expression profile of interferon tau–stimulated genes in ovine peripheral blood leukocytes during embryonic death

Cited by 30 publications

References 30 publications

Regulation of an Opioid Receptor Chaperone Protein, RTP4, by Morphine

Regulation of an Opioid Receptor Chaperone Protein, RTP4, by Morphine

Interferon Stimulated Genes (Isgs): Novel Pregnancy Specific Biomarker In Buffaloes (Bubalus bubalis

Conceptus-modulated innate immune function during early pregnancy in ruminants: a review

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