Expression profiles of selected genes in tumors and matched surgical margins in oral cavity cancer: Do we have to pay attention to the molecular analysis of the surgical margins?

Strzelczyk, Joanna Katarzyna; Krakowczyk, Łukasz; Gołąbek, Karolina; Owczarek, Aleksander

doi:10.17219/acem/79846

Cited by 4 publications

(2 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, there have also been tested a number of studies investigating the role of various genetic and molecular factors in postoperative material and surgical margins -including PTEN [56], TIMP3, SFRP1, SFRP2, CDH1, RASSF1, RORA, DAPK1 [57], TIL -tumour-infiltrating lymphocytes [58] and many others [59][60][61]. However, a clear statement of their clinical utility requires further research.…”

Section: Histologymentioning

confidence: 99%

The management of oral cancer – current standards and future perspectives. Review of the literature

Amrogowicz,

Rutkowski

2024

Nowotwory. Journal of Oncology

View full text Add to dashboard Cite

show abstract

Section: Histologymentioning

confidence: 99%

The management of oral cancer – current standards and future perspectives. Review of the literature

Amrogowicz,

Rutkowski

2024

Nowotwory. Journal of Oncology

View full text Add to dashboard Cite

show abstract

“…Several studies have investigated the potential of epigenetic changes in normal adjacent margins of the tumor as prognostic factors for OSCC patients [ 24 , 25 , 26 , 27 ]. Most of them showed that NAT samples, even if histologically negative for cancer cells, already have changes that can affect diagnosis and prognosis [ 27 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

HOXA1 3′UTR Methylation Is a Potential Prognostic Biomarker in Oral Squamous cell Carcinoma

Sorroche,

Miranda,

Beltrami

et al. 2024

Cancers

View full text Add to dashboard Cite

Background: HOXA1 is a prognostic marker and a potential predictive biomarker for radioresistance in head and neck tumors. Its overexpression has been associated with promoter methylation and a worse prognosis in oral squamous cell carcinoma (OSCC) patients. However, opposite outcomes are also described. The effect of the methylation of this gene on different gene regions, other than the promoter, remains uncertain. We investigated the methylation profile at different genomic regions of HOXA1 in OSCC and correlated differentially methylated CpG sites with clinicopathological data. Methods: The HOXA1 DNA methylation status was evaluated by analyzing data from The Cancer Genome Atlas and three Gene Expression Omnibus datasets. Significant differentially methylated CpG sites were considered with a |∆β| ≥ 0.10 and a Bonferroni-corrected p-value < 0.01. Differentially methylated CpGs were validated by pyrosequencing using two independent cohorts of 15 and 47 OSCC patients, respectively. Results: Compared to normal tissues, we found significantly higher DNA methylation levels in the 3′UTR region of HOXA1 in OSCC. Higher methylation levels in tumor samples were positively correlated with smoking habits and patients’ overall survival. Conclusions: Our findings suggest that HOXA1 gene body methylation is a promising prognostic biomarker for OSCC with potential clinical applications in patient monitoring.

show abstract

Impact of HPV infection on gene expression and methylation in oral cancer patients

Seńkowska

Kiczmer

Strzelczyk

et al. 2019

Journal of Medical Microbiology

View full text Add to dashboard Cite

Expression profiles of selected genes in tumors and matched surgical margins in oral cavity cancer: Do we have to pay attention to the molecular analysis of the surgical margins?

Abstract: Background. Head and neck squamous cell carcinomas (HNSCCs) are associated with an interplay between genetics and the environment; they account for 3% of all diagnosed malignant tumors in men and 2% of those in women.

Cited by 4 publications

References 59 publications

The management of oral cancer – current standards and future perspectives. Review of the literature

The management of oral cancer – current standards and future perspectives. Review of the literature

HOXA1 3′UTR Methylation Is a Potential Prognostic Biomarker in Oral Squamous cell Carcinoma

Impact of HPV infection on gene expression and methylation in oral cancer patients

Contact Info

Product

Resources

About