Expression quantitative trait loci in long non-coding RNA PAX8-AS1 are associated with decreased risk of cervical cancer

Han, Jing; Zhou, Wen; Jia, Meiqun; Wen, Juan; Jiang, Jie; Shi, Jufang; Zhang, Kai; Ma, Hongxia; Liu, Ji‐Bin; Ren, Jiansong; Dai, Min; Hu, Zhibin; Hang, Dong; Li, Ni; Shen, Hongbing

doi:10.1007/s00438-016-1217-9

Cited by 39 publications

(35 citation statements)

References 29 publications

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“…Recent reports showed that LINC00657 was induced by hypoxia in human endothelial cells and it might stimulate in regulating cell mitosis, DNA repair, and DNA replication [40, 41]. Previous studies identified two expression quantitative trait loci (eQTLs) SNPs located in lncRNA PAX8-AS1 that might influence the expression of target oncogene PAX8 and predict a decreased risk of cervical cancer [42–44]. Additionally, KCNQ1OT1, which was one of the most upregulated lncRNAs in GA samples of our study, was also defined as an oncogene and it has been reported to have significantly higher expression levels in breast cancer and other types of malignant tumors [45, 46].…”

Section: Discussionmentioning

confidence: 99%

Genome-wide analysis of differentially expressed lncRNAs and mRNAs in primary gonadotrophin adenomas by RNA-seq

Wang

et al. 2016

Oncotarget

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ABSTRACTsamples and normal pituitary tissues using RNA-seq. The differentially expressed lncRNAs and mRNAs were identified using fold-change filtering. We identified 839 lncRNAs and 1015 mRNAs as differentially expressed. Gene Ontology analysis indicated that the biological functions of differentially expressed mRNAs were related to transcription regulator activity and basic metabolic processes. Ingenuity Pathway Analysis was performed to identify 64 canonical pathways that were significantly enriched in the tumor samples. Furthermore, to investigate the potential regulatory roles of the differentially expressed lncRNAs on the mRNAs, we constructed general co-expression networks for 100 coding and 577 non-coding genes that showed significantly correlated expression patterns in tumor cohort. In particular, we built a special sub-network of co-expression involving 186 lncRNAs interacting with 15 key coding genes of the mTOR pathway, which might promote the pathogenesis of gonadotrophin tumor. This is the first study to explore the patterns of genome-wide lncRNAs expression and co-expression with mRNAs, which might contribute to the molecular pathogenesis of gonadotrophin adenoma.

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Section: Discussionmentioning

confidence: 99%

Genome-wide analysis of differentially expressed lncRNAs and mRNAs in primary gonadotrophin adenomas by RNA-seq

Wang

et al. 2016

Oncotarget

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“…Recently, an association between the rs2147578 polymorphism of lnc-LAMC2-1 and risk of childhood ALL has been demonstrated (6). There is limited information on the impact of PAX8-AS1 polymorphisms on cancer risk (19,24). Han et al (19) demonstrated that PAX8-AS1 rs4848320 and rs1110839 polymorphisms decreased the risk of cervical cancer, while Ma et al (24) reported that rs4848320 and rs1110839 were associated with prognosis of HCC in a Chinese population.…”

Section: Discussionmentioning

confidence: 99%

“…LncRNA PAX8 antisense RNA 1 (PAX8-AS1) is mapped to chromosome 2q13 in the upstream region of PAX8 (19). An expression quantitative trait loci (eQTL) is a locus containing a genetic variant that influences the expression level of a gene (20).…”

Section: Introductionmentioning

confidence: 99%

“…Few previous studies have evaluated the impact of PAX8-AS1 variants on cancer risk. Han et al (19) reported that rs4848320 and rs1110839 variants of PAX8-AS1 significantly decreased the risk of cervical cancer (19). Ma et al (24) identified that the two variants of PAX8-AS1 were significantly associated with the prognosis of hepatocellular carcinoma (HCC).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the present study aimed to assess the possible association between the PAX8-AS1 polymorphisms rs4848320 C>T, rs1110839 G>T and rs6726151 T>G and the risk of childhood ALL in a Southeast Iranian population sample. In the analysis, the polymorphisms which have been implicated as potential risk factors for cancer were selected (19,24), while the rs6726151 T>G variant, with a minor allele frequency of 0.486 (25), was examined for the first time. The findings of the present study highlight the potential role of PAX8-AS1 variants in the pathogenesis of childhood ALL.…”

Section: Introductionmentioning

confidence: 99%

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Long non‑coding RNA PAX8‑AS1 polymorphisms increase the risk of childhood acute lymphoblastic leukemia

et al. 2017

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Abstract. The present case-control study was conducted on 110 children with acute lymphoblastic leukemia (ALL) and 120 healthy children to determine the impact of polymorphisms in paired-box gene 8 (PAX8) antisense RNA 1 (PAX8-AS1), namely rs4848320 C>T, rs6726151 T>G and rs1110839 G>T, on ALL risk. Genotyping was performed through the polymerase chain reaction-restriction fragment length polymorphism method. The findings indicated that the rs4848320 variant increased the risk of ALL in codominant [CT vs. CC: odds ratio (OR)=2.13, 95% confidence interval (CI)=1.16-3.90, P=0.014; and TT vs. CC: OR=2.21, 95% CI=1.03-4.74, P=0.041], dominant (CT+TT vs. CC: OR=2.15, 95% CI=1.22-3.81, P=0.009,) and allele (T vs. C: OR=1.55, 95% CI=1.07-2.25, P=0.024) inheritance models. The rs6726151 variant significantly increased the risk of ALL in codominant (GT vs. GG: OR=1.88, 95% CI=1.08-3.27, P=0.036) and overdominant (GT vs. GG+TT: OR=2.08, 95% CI=1.23-3.53, P=0.008) inheritance models. No significant relationship was identified between the rs1110839 G>T variant and disease risk/protection in childhood ALL. In conclusion, the findings of the present study indicated that rs4848320 and rs6726151 polymorphisms of PAX8-AS1 may be a risk factor for the development of childhood ALL. Further studies with larger sample sizes and different ethnicities are now required to confirm these findings.

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Identification and clinical value of a new ceRNA axis (TIMP3/hsa‐miR‐181b‐5p/PAX8‐AS1) in thyroid cancer

Liang,

Deng,

Zhang

et al. 2024

Health Science Reports

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BackgroundThyroid cancer (TC) is a prevalent and increasingly common malignant tumor. In most cases, TC progresses slowly and runs a virtually benign course. However, challenges remain with the treatment of refractory TC, which does not respond to traditional management or is subject to relapse or metastasis. Therefore, new therapeutic regimens for TC patients with poor outcomes are urgently needed.MethodsThe differentially expressed RNAs were identified from the expression profile data of RNA from TC downloaded from The Cancer Genome Atlas database. Multiple databases were utilized to investigate the regulatory relationship among RNAs. Subsequently, a competitive endogenous RNA (ceRNA) network was established to elucidate the ceRNA axis that is responsible for the clinical prognosis of TC. To understand the potential mechanism of ceRNA axis in TC, location analysis, functional enrichment analysis, and immune‐related analysis were conducted.ResultsA ceRNA network of TC was constructed, and the TIMP3/hsa‐miR‐181b‐5p/PAX8‐AS1 ceRNA axis associated with the prognosis of TC was successfully identified. Our results showed that the axis might influence the prognosis of TC through its regulation of regulating tumor immunity.ConclusionsOur findings provide evidence that TIMP3/hsa‐miR‐181b‐5p/PAX8‐AS1 axis is significantly related to the prognosis of TC. The molecules involved in this axis may serve as novel therapeutic approaches for TC treatment.

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Expression quantitative trait loci in long non-coding RNA PAX8-AS1 are associated with decreased risk of cervical cancer

Cited by 39 publications

References 29 publications

Genome-wide analysis of differentially expressed lncRNAs and mRNAs in primary gonadotrophin adenomas by RNA-seq

Genome-wide analysis of differentially expressed lncRNAs and mRNAs in primary gonadotrophin adenomas by RNA-seq

Long non‑coding RNA PAX8‑AS1 polymorphisms increase the risk of childhood acute lymphoblastic leukemia

Identification and clinical value of a new ceRNA axis (TIMP3/hsa‐miR‐181b‐5p/PAX8‐AS1) in thyroid cancer

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