Expressions of insulin-like growth factor receptor-1 and cezanne-1 in lung adenocarcinoma

Abstract

IGF1R (insulin-like growth factor receptor-1) was confirmed to play a significant role in the development of cancer. Cezanne-1 overexpression was considered to be associated with enhancement of EGFR signaling pathway and reduced degeneration of EGFR. There was a close relationship between EGFR and IGFR as previous study showed. Dynamic balance between receptor ubiquitination and deubiquitination was critical in the process of termination of IGF signaling pathway. So we conducted an IHC staining to initially prove the correlation. Cezanne-1 and IGF1R expressions were evaluated in 103 patients with lung adenocarcinoma using immunohistochemical (IHC) analysis. The relationship between expressions of cezanne-1 and IGF1R were analyzed by χ2 test. Kaplan-Meier method was used to generate the survival curve, and the statistical difference was calculated by log-rank test. We also used data in R2 system to verify the relationship between IGF1R and cezanne-1. R2 system showed there was a close correlation between IGF1R and cezanne-1. Positive expression of cezanne-1 was detected in 64.1% patients. A significant association was shown between cezanne-1 and IGF1R expression (p < 0.001). Multivariate analysis confirmed that both cezanne-1 and IGF1R expressions were independent prognostic factors for OS. (HR 2.96, 95% CI 1.090-8.060, p = 0.033; HR 2.273, 95% CI 1.016-5.085, p = 0.046, respectively). Our findings indicated both cezanne-1 and IGF1R expressions were negative independent predictive factors for the prognosis of lung adenocarcinoma, respectively. There was a close positive interrelationship between cezanne-1 and IGF1R expression.

Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway

“…6a). As the previous reports, OTUD7B regulated deubiquitination and endocytosis of EGFR associated with breast cancer proliferation, migration and malignancy [18]. Subsequently, the interaction between OTUD7B and EGFR was confirmed by co-immunoprecipitation and immunofluorescent staining (Fig.…”

Upregulation of OTUD7B (Cezanne) Promotes Tumor Progression via AKT/VEGF Pathway in Lung Squamous Carcinoma and Adenocarcinoma

“…In spite of the rapid development of diagnostic and therapeutic technologies for NSCLC, its outcome remains poor, which may due to the lack of specific targets at the early stage (2, 30). Recent studies have demonstrated OTUD7B as a gene highly expressed in lung adenocarcinoma tissues (12, 18). In the present study, OTUD7B was revealed to overexpressed within LAD and LUSC tissues compared with adjacent noncancerous tissues.…”

“…Although some evidence revealed the role of OTUD7B in cancer progression (10, 12, 15–18), the molecular mechanisms of OTUD7B participation in invasion and metastasis in NSCLCs remains elusive. Here, we demonstrate that OTUD7B were predominantly upregulated in LUSC and LAD tissues compared with adjacent normal lung tissues.…”

Multi-Omics Data Analysis Uncovers Molecular Networks and Gene Regulators for Metabolic Biomarkers

“…One unique pathway involved, EGFR signaling, has been implicated in glucose homeostasis by regulating beta-cell proliferation in response to increased metabolic demand [53]. Notably, EGFR signaling is associated with IGF-IR expression and IGF-I secretion in cancer cells [54,55], contributing to cancer cell growth and poor survival; thus, dual targeting at EGFR and the IGF/IR axis has been suggested to be a promising therapeutic strategy for overcoming drug-acquired resistance in several cancer types, such as lung adenocarcinoma, head and neck squamous cell and colorectal carcinomas, and glioblastoma [55][56][57][58].…”