Expressions of miR-132, miR-134, and miR-485 in rat primary motor cortex during transhemispheric functional reorganization after contralateral seventh cervical spinal nerve root transfer following brachial plexus avulsion injuries

Wang, Xinhong; Li, Lijun; Sun, Guixin; Wu, Zuopei; Li, Jifeng; Gu, Yajia

doi:10.1097/wnr.0000000000000485

Cited by 7 publications

(3 citation statements)

References 24 publications

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“…Numerous studies have suggested that miR-142-5p and miR-134-5p are closely related to nervous system diseases and peripheral nerve injury [33][34][35][36][37][38] . Previous studies have con rmed that MiR-142-5p plays a role in protecting nerves and promoting nerve repair by regulating the viability and apoptosis of neuronal cells during nerve injury repair 24 .…”

Section: Mir-134-5p Promotes the Proliferation And Migration Of Schwa...mentioning

confidence: 99%

Analysis of miRNA expression profile of sciatic nerve in rats with spinal cord injury

Jiang

Zhang

et al. 2023

Preprint

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After spinal cord injury, the downstream peripheral nerves lose control, and the tissues lose the protection of peripheral nerves, which is easy to cause skin and soft tissue injury and wound difficult to heal. However, the underlying mechanisms are still unknown. In order to explore the mechanism of functional changes in peripheral nerves deprived of spinal cord control, we established a model of sciatic nerve transection injury combined with spinal cord transection injury in Sprague-Dawley (SD) rats, and small RNA sequencing analysis, tissue staining and molecular experiments were used to analyze the changes in miRNA expression and degeneration of peripheral nerve stump. The results showed that after loss of spinal cord innervation, the response of rats to sciatic nerve injury was weakened, and Wallerian degeneration could not occur normally and angiogenesis was abnormal. Moreover, differentially expressed miRNAs were detected in the sciatic nerve stump of the two groups of rats with or without spinal cord injury. Specifically, miR-134-5p and miR-142-5p were decreased in the sciatic nerve stump after spinal cord injury. Therefore, we suggest that spinal cord injury may inhibit the repair process of sciatic nerve injury by down-regulating the expression of miR-134-5p / miR-142-5p.

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Section: Mir-134-5p Promotes the Proliferation And Migration Of Schwa...mentioning

confidence: 99%

Analysis of miRNA expression profile of sciatic nerve in rats with spinal cord injury

Jiang

Zhang

et al. 2023

Preprint

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“…Factors participating in the network of motor cortical remodelling after BPRA display dynamic changes. Major microRNAs (miRNAs/miRs) distributed in the motor cortex, such as miR-101-3p, miR-132, miR-134, miR-137-3p and miR-485, play vital roles in regulating neural plasticity and transhemispheric functional reorganization dendrite morphology, spontaneous synaptic responses and transmitter release after cervical spinal nerve root transfer following BPA injury [61,81,86]. Functional MRI studies revealed that the levels of proinflammatory cytokines, such as interleukin (IL)-1β, IL-6, tumour necrosis factor α (TNF-α), are important mediators in the neural plasticity and transhemispheric functional reorganization [33,36,57,98].…”

Section: Brain Changesmentioning

confidence: 99%

Therapeutic strategies for brachial plexus injury

Hong¹,

Chen²,

Wu³

et al. 2021

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Brachial plexus avulsion (BPA), a severe acute peripheral nerve injury in adults, results in total loss of the motor function in the upper limb. Although immediate re-implantation surgery is widely performed to repair this lesion, the motor function cannot be fully restored. The main cause is that the growth velocity of axon is extremely slow in order to re-innervate the target muscles before atrophy develops. Therefore, the survival of spinal motoneurons (MNs) is considered to be a prerequisite for the recovery of motor function. The introduction of survival-proactive agents with anti-oxidative stress and anti-inflammation properties has emerged as a new approach to the motor function recovery following BPA. In the current review, we summarized the treatments of BPA in both mouse and rat models following re-implantation surgery. Furthermore, the pain treatment options following BPA were discussed.

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“…miRNAs exert a significant effect on oncogenesis (Piotrowski et al, 2021;Tan et al, 2021). At present, miRNA expression has been observed in various tumours and is closely related to tumour growth (Jiang et al, 2016), metastasis (Wang et al, 2016), angiogenesis (Lu et al, 2015), and other malignant biological characteristics; thus, it is considered an indispensable regulator of tumorigenesis. Therefore, miRNAs detection is beneficial for early clinical diagnosis; moreover, modulating their expression in tumours may have potential clinical values.…”

Section: Introductionmentioning

confidence: 99%

miR-181b promotes the oncogenesis of renal cell carcinoma by targeting TIMP3

Zou¹,

Zhang²,

Zhong³

2022

Biocell

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Renal cell carcinoma (RCC) has a poor prognosis due to limited diagnosis and treatment. Thus, it is necessary to find novel prognostic biomarkers and therapeutic targets. The aberrant expression of microRNAs plays an important role in RCC oncogenesis. Tissue inhibitors of metalloproteinase 3 (TIMP3) acts as a downstream target of miR-181b. The aim of this study was to understand the role and molecular mechanism of miR-181b in RCC oncogenesis. The results showed that miR-181b expression was significantly higher in RCC tumour tissues, especially in those with significant invasion or metastasis. miR-181b overexpression promoted proliferation and migration of the RCC cell line 786-O, while miR-181b knockdown had the opposite effect. In addition, miR-181b was inversely correlated with TIMP3 expression in RCC tumour tissues. miR-181b overexpression reduced TIMP3 expression in RCC cell line 786-O or OS-RC-2, while miR-181b knockdown had the inverse effect. Mechanistically, a luciferase reporter assay confirmed the binding sites of miR-181b on the 3'-UTR of TIMP3, confirming the targeting effect of miR-181b on TIMP3.Overall, miR-181b promotes the development and progression of RCC by targeting TIMP3 expression, indicating the potential use of miR-181b in the diagnosis and treatment of RCC.

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Expressions of miR-132, miR-134, and miR-485 in rat primary motor cortex during transhemispheric functional reorganization after contralateral seventh cervical spinal nerve root transfer following brachial plexus avulsion injuries

Cited by 7 publications

References 24 publications

Analysis of miRNA expression profile of sciatic nerve in rats with spinal cord injury

Analysis of miRNA expression profile of sciatic nerve in rats with spinal cord injury

Therapeutic strategies for brachial plexus injury

miR-181b promotes the oncogenesis of renal cell carcinoma by targeting TIMP3

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