Expressive language characteristics of schizophrenic subjects with different medication histories

Goren, Anat; Swindell, Carol S.; Khan, Arifulla

doi:10.1016/0911-6044(92)90011-k

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…Goren et al [25] compared the language performances in schizophrenic patients before and after two weeks of treatment with those of patients who had received uninterrupted treatment for seven weeks. A clear improvement in performance in the former group of patients was seen, whose performance became similar to that exhibited by the second group following two weeks of treatment.…”

Section: Psycholinguistic Measuresmentioning

confidence: 99%

“…Most studies show that conventional NL treatments, at a therapeutic dosage and in acute or chronic mode, reduce, but do not normalize, language disorders in schizophrenia [12,14,19,20,25,26,30,50,51].…”

Section: Schizophrenic Patientsmentioning

confidence: 99%

“…Clinical measures indicate a clear reduction of idiosyncratic responses [12,51] and PTD [19,20,26,51]. Linguistic and psycholinguistic measurements reveal a reduction in the level of aberrant utterances and an improvement in verbal performance [14,25,30]. The discontinuation of NL treatment appears to improve the acoustic measures [5] and enhance verbal fluency [10], although this latter result has been contested [21,30].…”

Section: Schizophrenic Patientsmentioning

confidence: 99%

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The effects of psychoactive drugs and neuroleptics on language in normal subjects and schizophrenic patients: a review

2000

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The aim of this survey is to present an overview of research into psychopharmacology as regards the effects of different psychoactive drugs and neuroleptics (NL) on language in normal subjects and schizophrenic patients. Eighteen studies that have investigated the effects of different drugs (alcohol, amphetamines, secobarbital, L-dopa, psilocybin, ketamine, fenfluramine) and neuroleptics (conventional and atypical) on language are reviewed. There are no studies concerning the effects of neuroleptics on language in healthy subjects. The results of the effects of other molecules indicate that language production can be increased (alcohol, amphetamine, secobarbital), rendered more complex (d-amphetamine), more focused (L-dopa) or more unfocused (psilocybin) and clearly impaired (ketamine). For schizophrenic patients, most studies show that conventional neuroleptic treatments, at a therapeutic dosage and in acute or chronic mode, reduce language disorders at all levels (clinic, linguistic, psycholinguistic). In conjunction with other molecules, the classical NL, when administered at a moderate dosage and in chronic mode, modify language in schizophrenia, either by improving the verbal flow and reducing pauses and positive thought disorder (NL + amphetamine) or by inducing an impairment in the language measurements (NL + fenfluramine). Clinical, methodological and theoretical considerations of results are debated in the framework of schizophrenic language disorders.

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Section: Psycholinguistic Measuresmentioning

confidence: 99%

Section: Schizophrenic Patientsmentioning

confidence: 99%

Section: Schizophrenic Patientsmentioning

confidence: 99%

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The effects of psychoactive drugs and neuroleptics on language in normal subjects and schizophrenic patients: a review

2000

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Dissecting the neurobiology of linguistic disorganisation and impoverishment in schizophrenia

Palaniyappan

2022

Seminars in Cell & Developmental Biology

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Los efectos de las sustancias psicoactivas y los neurolépticos sobre el lenguaje en sujetos normales y pacientes esquizofrénicos: una revisión

Salomé

Boyer

Fayol

2001

Eur. psychiatr. (Ed. esp.)

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ResumenEl propósito de este estudio es presentar una visión general de la investigación en psicofarmacología con respecto a los efectos de diferentes sustancias psicoactivas y neurolépticos (NL) sobre el lenguaje en sujetos normales y pacientes esquizofrénicos. Se revisan dieciocho estudios que han investigado los efectos a este respecto de sustancias psicoactivas (alcohol, anfetaminas, secobarbital, L-dopa, psilocibina, ketamina, fenfluramina) y neurolépticos (convencionales y atípicos) diferentes. No hay estudios acerca de los efectos de los neurolépticos sobre el lenguaje en los sujetos sanos. Los resultados obtenidos con otras moléculas indican que la producción del lenguaje puede aumentar (alcohol, anfetamina, secobarbital), hacerse más compleja (d-anfetamina), más enfocada (L-dopa) o más desenfocada (psilocibina) y deteriorate claramente (ketamina). Para los pacientes esquizofrénicos, la mayoría de los estudios muestra que los tratamientos neurolépticos convencionales en dosis terapéuticas y en modo breve o prolongado, reducen los trastornos del lenguaje en todos los niveles (clínico, linguistico, psicolingüístico). Los NL cIásicos, cuando se administran en dosis moderadas y de modo prolongado en unión con otras moléculas, modifican el lenguaje en la esquizofrenia, mejorando la fluidez verbal y reduciendo las pausas y el trastorno positivo de pensamiento (NL+ anfetamina), o induciendo un deterioro en las medidas de lenguaje (NL+ fenfluramina). Se debaten consideraciones clínicas, metodológicas y teóricas de los resultados en el marco de los trastornos de lenguaje de los esquizofrénicos.

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Expressive language characteristics of schizophrenic subjects with different medication histories

Cited by 5 publications

References 12 publications

The effects of psychoactive drugs and neuroleptics on language in normal subjects and schizophrenic patients: a review

The effects of psychoactive drugs and neuroleptics on language in normal subjects and schizophrenic patients: a review

Dissecting the neurobiology of linguistic disorganisation and impoverishment in schizophrenia

Los efectos de las sustancias psicoactivas y los neurolépticos sobre el lenguaje en sujetos normales y pacientes esquizofrénicos: una revisión

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