Extemporaneous Suspension of Propafenone: Attending Lack of Pediatric Formulations in Mexico

Abstract

The conservation of both physicochemical and microbiologic stability of the suspension represents an option for the administration of propafenone to children.

Approach to Optimize Pharmacological Treatment in Children

“…Outstanding among his studies are those performed for the development of propafenone pediatric suspension, an efficacious pediatric antiarrhythmic, the patent of which was authorized to him, and the proper use of sildenafil in the treatment of pulmonary arterial hypertension. 11,12…”

“…Outstanding among his studies are those performed for the development of propafenone pediatric suspension, an efficacious pediatric antiarrhythmic, the patent of which was authorized to him, and the proper use of sildenafil in the treatment of pulmonary arterial hypertension. 11,12 One of the strategies in the obtention of knowledge that supports clinical-hospital decision-making is pharmacokinetic and pharmacodynamic study. From all these immense works arose the notion to transfer his research experiences in the book "Optimization of Drug Prescribing in Children," recently published by Nova Science Publishing House, where he has documented in black and white his years of invaluable knowledge which he puts to the disposition of the readers seeking information on the proper management of medicines in the pediatric population.…”

Paediatric Medicines: Formulation Considerations

“…Although there is lack of studies on the quality and stability of extemporaneous preparations, some authors have developed stability studies with simple formulations for some drugs frequently administered off-label and unlicensed, such as sildena il [15,16], metformin [17], clonidine [18], propafenone [19]. Moreover the bioavailability of extemporaneous preparations is not studied, however it is well known that the bioavailability of the drug is modi ied when a dosage form is extemporaneously compounded [11,20].…”