Extended attack from a resident conspecific is critical to the development of long-lasting analgesia in male intruder mice

Rodgers, R.J.; Randall, J.I.

doi:10.1016/0031-9384(86)90116-2

Cited by 16 publications

(10 citation statements)

References 9 publications

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“…However, hyperalgesia during alcohol WD is not reversed by inhibition of corticosteroid synthesis or accompanied by other behavioral indicators of intense stress (e.g., changes in behavior in the elevated plus maze; Smith et al, 2016). Moreover, intense stress has been shown repeatedly to lead to hypoalgesia in observers rather than hyperalgesia (Miczek et al, 1985; Rodgers and Randall, 1986; Kavaliers et al, 2001), and blocking glucocorticoid signaling in an observer to reduce social stress can unmask socially transferred hyperalgesia (Martin et al, 2015). Viewed collectively, these lines of evidence argue that while alcohol WD may involve some stress-related elements, exposure to social cues related to alcohol WD does not.…”

Section: Discussionmentioning

confidence: 99%

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Anterior Cingulate Cortex Contributes to Alcohol Withdrawal- Induced and Socially Transferred Hyperalgesia

Smith

Walcott

Heinricher

et al. 2017

eNeuro

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Pain is often described as a “biopsychosocial” process, yet social influences on pain and underlying neural mechanisms are only now receiving significant experimental attention. Expression of pain by one individual can be communicated to nearby individuals by auditory, visual, and olfactory cues. Conversely, the perception of another’s pain can lead to physiological and behavioral changes in the observer, which can include induction of hyperalgesia in “bystanders” exposed to “primary” conspecifics in which hyperalgesia has been induced directly. The current studies were designed to investigate the neural mechanisms responsible for the social transfer of hyperalgesia in bystander mice housed and tested with primary mice in which hyperalgesia was induced using withdrawal (WD) from voluntary alcohol consumption. Male C57BL/6J mice undergoing WD from a two-bottle choice voluntary alcohol-drinking procedure served as the primary mice. Mice housed in the same room served as bystanders. Naïve, water-drinking controls were housed in a separate room. Immunohistochemical mapping identified significantly enhanced Fos immunoreactivity (Fos-ir) in the anterior cingulate cortex (ACC) and insula (INS) of bystander mice compared to naïve controls, and in the dorsal medial hypothalamus (DMH) of primary mice. Chemogenetic inactivation of the ACC but not primary somatosensory cortex reversed the expression of hyperalgesia in both primary and bystander mice. These studies point to an overlapping neural substrate for expression of socially transferred hyperalgesia and that expressed during alcohol WD.

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Section: Discussionmentioning

confidence: 99%

“…Social factors can depress or enhance pain in rodents. For example, social stress, such as repeated defeat by a dominant conspecific, results in antinociception in rodents (Miczek et al, 1985; Rodgers and Randall, 1986). Stress-related social odors have similarly been shown to produce antinociception in conspecifics (Fanselow, 1985).…”

Section: Introductionmentioning

confidence: 99%

Anterior Cingulate Cortex Contributes to Alcohol Withdrawal- Induced and Socially Transferred Hyperalgesia

Smith

Walcott

Heinricher

et al. 2017

eNeuro

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“…After only a single agonistic episode, resident mice are hyper-algesic on a hotplate, whereas defeated intruders show a hypo-algesic behavioral response [15]. Similarly, extended exposure to attack is essential to the development of an enduring (opioid-typical) analgesia [16].…”

Section: Introductionmentioning

confidence: 99%

A Trouble Shared Is a Trouble Halved: Social Context and Status Affect Pain in Mouse Dyads

et al. 2009

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In mice behavioral response to pain is modulated by social status. Recently, social context also has been shown to affect pain sensitivity. In our study, we aimed to investigate the effects of interaction between status and social context in dyads of outbred CD-1 male mice in which the dominance/submission relationship was stable. Mice were assessed for pain response in a formalin (1% concentration) test either alone (individually tested-IT), or in pairs of dominant and subordinate mice. In the latter condition, they could be either both injected (BI) or only one injected (OI) with formalin. We observed a remarkable influence of social context on behavioral response to painful stimuli regardless of the social status of the mice. In the absence of differences between OI and IT conditions, BI mice exhibited half as much Paw-licking behavior than OI group. As expected, subordinates were hypoalgesic in response to the early phase of the formalin effects compared to dominants. Clear cut-differences in coping strategies of dominants and subordinates appeared. The former were more active, whereas the latter were more passive. Finally, analysis of behavior of the non-injected subjects (the observers) in the OI dyads revealed that dominant observers were more often involved in Self-grooming behavior upon observation of their subordinate partner in pain. This was not the case for subordinate mice observing the pain response of their dominant partner. In contrast, subordinate observers Stared at the dominant significantly more frequently compared to observer dominants in other dyads. The observation of a cagemate in pain significantly affected the observer's behavior. Additionally, the quality of observer's response was also modulated by the dominance/submission relationship.

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“…Furthermore, the present data are not in agreementwith the reported analgesic tail-flick reactions that follow conspecific defeat, using other species and resident-intruder procedures. Male mice have been found to show analgesia, which is naloxone-reversible and cross-tolerant with morphine, after repeated exposure to agonistic defeat as colony intruders (Miczeket al, 1982(Miczeket al, , 1986Rodgers & Randall, 1986b). It hasalso beenreported that miceshowa nonopioid analgesic reactionimmediately following a singleencounter with an aggressiveresident (Rodgers& Randall, 1986a)or to the scent of a dominant mouse (Rodgers & Randall, 1986c).…”

Section: Discussionmentioning

confidence: 99%

“…This type of natural stressor also decreases subsequent exploratory behavior and increases freezing (e.g., Raab et al, 1986). Finally, repeated defeat by conspecifics produces many of the physiological changesthat also occur as a result of shockinduced learned helplessness, such as weight loss (e.g., Adams & Boice, 1983;Luciano & Lore, 1975;Thor & Flannelly, 1976;Raab et al, 1986), endocrine changes (e.g., Raab et al, 1986), and analgesia that is mediated by endogenous opioid mechanisms (e.g., Miczek, Thompson, & Shuster, 1982, 1986Rodgers& Randall, 1986b) and nonopioid mechanisms (McAllister, Berry, & Brain, 1985;Rodgers & Randall, 1986a).…”

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confidence: 99%

Effects of repeated defeat by a dominant conspecific on subsequent pain sensitivity, open-field activity, and escape learning

Williams

Lierle

1988

Animal Learning & Behavior

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Male rats were tested as intruders for 25 consecutive days in colonies that had either aggressive (i.e., alpha) or nonaggressive conspecific residents. Alpha-defeated intruders, in contrast to nondefeated rats, showed more defensive behavior, less gain in body weight, and received more bites during the course of these sessions. Tail-flick tests, using a heat source, revealed that both groups of intruders showed comparable sensitivity/reactivity to pain, and there was no evidence of analgesia as a function of resident encounters. Immediately after the last intruder session, all subjects were tested for exploratory activity in an open-field apparatus with the odors (i.e., soiled bedding) from the alpha colonies present. Defeated intruders showed significantly less locomotion, in terms of the number of grid crossings, than nondefeated rats. Twenty-four hours later, randomly selected subgroups of defeated and nondefeated subjects were briefly exposed, without being defeated, to aggressive colonies, and all rats were then retested for activity with alpha odors present. Previously defeated intruders were again less active, and the colony-exposure treatment suppressed the activity of defeated, but not nondefeated, subjects. Finally, 24 h after another resident-intruder session, both groups of intruders showed comparable FR 1 escape performance in a shuttlebox with alpha odors present, but the defeated rats failed to learn a subsequent FR 2 escape task. The findings of this experiment are discussed in terms of the concept of "learned helplessness," the effects of ethological stressors, and the authors' stress-coping-fear-defense (SCFD) theory.Numerous investigators have shown that repeated exposure to a laboratory stressor, such as electric shock, produces alterations in behavioral and neurophysiological processes. In mice and rats, experiencing inescapable shock has been shown to interfere with the subsequent acquisition of escape responses (e.g., Anisman, Suissa,

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Extended attack from a resident conspecific is critical to the development of long-lasting analgesia in male intruder mice

Cited by 16 publications

References 9 publications

Anterior Cingulate Cortex Contributes to Alcohol Withdrawal- Induced and Socially Transferred Hyperalgesia

Anterior Cingulate Cortex Contributes to Alcohol Withdrawal- Induced and Socially Transferred Hyperalgesia

A Trouble Shared Is a Trouble Halved: Social Context and Status Affect Pain in Mouse Dyads

Effects of repeated defeat by a dominant conspecific on subsequent pain sensitivity, open-field activity, and escape learning

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