Extended Cycles with the Combined Oral Contraceptive Chlormadinone Acetate 2 mg/Ethinylestradiol 0.03 mg

Abstract

This pooled analysis confirms that extended regimens of CMA 2 mg/EE 0.03 mg reduce cycle-related complaints and are very well tolerated.

The Sexual Acceptability of Contraception: Reviewing the Literature and Building a New Concept

“…In the past 10 years, several specific branded pills and hormonal combinations have received attention in the literature due to their potential impact on women's sexual experiences. Studies of Yasmin ® (Battaglia et al, 2012;Battaglia et al, 2014;Drosdzol & Skrzypulec, 2008;Goldstein, Burrows, & Goldstein, 2010;Mabrouk et al, 2012), Q(K) laira ® (Caruso et al, 2011;, and Belara ® (Caruso, Rugolo, Agnello, Romano, & Cianci, 2009;Göretzlehner, Waldmann-Rex, & Schramm, 2011) make up almost one-third (n = 10) of all combined OC articles identified in the review. Yasmin, containing 30 μg ethinylestradiol (EE) and 3 mg drospirenone (DRSP), has received a particularly high level of attention (n = 5).…”

“…Extended cycle regimens, or continuous pill use without a hormonefree week for several cycles, have also been associated with positive changes across a variety of sexual acceptability factors, from sexual functioning to aesthetics. These include improvements in sexual function and libido, reductions in dysmenorrhea, duration and volume of withdrawal bleeds, and breast tenderness, and improvements in skin problems (Caruso et al, 2011;Caruso et al, 2013;Göretzlehner et al, 2011). However, other aspects of combined OC use, such as breakthrough bleeding, breast tenderness (Mabrouk et al, 2012;Roumen, 2007), and vaginal dryness (Sabatini & Cagiano, 2006), are likely to detract from sexual acceptability and should be further explored.…”

Acute and Preventive Management of Migraine during Menstruation and Menopause

“…An alternative strategy to prevent MM in women seeking contraception is to use specific formulations of low-dose estrogens and/or progestins, such as estradiol valerate plus dienogest [80]. Continuous administration of estrogen, without [81] or with a reduced time hormone-free interval [82], or the use of non-oral formulations, such as the vaginal ring [83], also showed efficacy in decreasing the burden of MM (Figure 4). At least 50% reduction in monthly headache days in all treated women; improvement in menstrual symptoms An alternative strategy to prevent MM in women seeking contraception is to use specific formulations of low-dose estrogens and/or progestins, such as estradiol valerate plus dienogest [80].…”

“…At least 50% reduction in monthly headache days in all treated women; improvement in menstrual symptoms An alternative strategy to prevent MM in women seeking contraception is to use specific formulations of low-dose estrogens and/or progestins, such as estradiol valerate plus dienogest [80]. Continuous administration of estrogen, without [81] or with a reduced time hormone-free interval [82], or the use of non-oral formulations, such as the vaginal ring [83], also showed efficacy in decreasing the burden of MM (Figure 4). An alternative modality of hormonal manipulation is the use of phytoestrogen; the daily use of a combination of soy isoflavones, dong quai, and black cohosh, all of which contain phytoestrogens, effectively decreased headache frequency in women with menstrual-related migraine without aura in a randomized controlled trial [84].…”