Extended Evaluation of Allergic BronchopuImonary Aspergillosis

Ghory, Ann C.; Patterson, Roy; Greenberger, Paul A.; Roberts, Mary

doi:10.1159/000232524

Cited by 6 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ABPA diagnosis was made by using the Rosenberg and Patterson criteria. It was diagnosed if they met six of the eight following criteria: bronchial asthma, the presence of Aspergillus skin test type I reaction, elevated total IgE levels (>1000 IU/mL), elevated specific IgE levels against A.fumigatus (>0.35 kUA/L), the presence of serum precipitating antibodies against A. fumigatus , absolute eosinophil count > 1000/mL, radiological pulmonary opacities (fixed/transient) by chest X‐ray and central bronchiectasis by HRCT findings …”

Section: Study Population and Methodsmentioning

confidence: 99%

Need to re‐look cut‐off of Aspergillus‐specific IgE levels in children with ABPA

Singh

Chauhan

Paul

et al. 2019

Mycoses

View full text Add to dashboard Cite

Summary The cut‐offs for total and specific IgE used for diagnosing ABPA in children have been adopted from adult literature and have not been validated in the paediatric population. To establish the ideal cut‐offs of total IgE and Aspergillus‐specific IgE for the diagnosis of ABPA in children. This study was a prospective observational case‐control study, conducted in a tertiary care hospital in North India, enrolling 140 children with partly controlled and uncontrolled asthma. Seventy children had ABPA based on the Rosenberg‐Patterson Criteria (Cases) whereas 70 children were without ABPA (Controls). All children were subjected to clinical examination and investigations such as absolute eosinophil count, total IgE, Aspergillus‐specific IgE, Aspergillus skin prick test and radiological tests. ROC curve analysis was done to determine the ideal cut‐offs of total and specific IgE to diagnose ABPA. The ROC curve analysis determined 1204IU/L as the cut‐off value of total IgE with a sensitivity of 79.7% (95%CI 68.31% to 88.44%) and specificity of 53.1% (95%CI 40.23 to 65.7). The ROC analysis of specific IgE levels of children with ABPA determined the cut‐off value of 0.49 KAU/L with a sensitivity of 94.03% (95%CI 85.41 to 98.35) and specificity of 88.89% (95%CI 75.94% to 96.29%). We propose that the cut‐offs of total and specific IgE need to be relooked in the paediatric population. Cut‐offs of total IgE as 1204 IU/L and for Aspergillus‐specific IgE as 0.49KAU/L seem appropriate. Large multicentric studies should be conducted to determine the ideal values for diagnosing paediatric ABPA.

show abstract

Section: Study Population and Methodsmentioning

confidence: 99%

Need to re‐look cut‐off of Aspergillus‐specific IgE levels in children with ABPA

Singh

Chauhan

Paul

et al. 2019

Mycoses

View full text Add to dashboard Cite

show abstract

“…Nevertheless, there is a strong suspicion that ABPA is more common in Britain than in North America, even allowing for possible differences in diagnostic awareness. [6][7][8] One British report recorded a prevalence of ABPA of 22 percent among asthmatic chest clinic attenders, 3 but this almost certainly overestimates the overall figure in Britain, since skin test surveys of large numbers of atopic asthmatics have revealed prevalences of skin prick test reactivity to Aspergillus fumigatus on the order of 15 to 20 percent only. 9,10 It is doubtful whether as many as 50 percent or even 25 percent of these prick test reactors actually have ABPA.…”

Section: Prevalencementioning

confidence: 99%