Extended Follow-Up and Outcomes of Patients Undergoing Pancreaticoduodenectomy for Nonmalignant Disease

Abstract

Although some patients experienced symptoms that negatively impacted their daily life or had diabetic issues following surgery, the outcome of patients undergoing PD for nonmalignant indications was generally favorable. Further prospective study is warranted.

Risk factors for development of diabetes mellitus (Type 3c) after partial pancreatectomy: A systematic review

“…Sample sizes in individual studies ranged from 20 to 4775 patients, with a total of 9970 patients included for analysis. Table summarizes the study characteristics and key results for the included studies . These studies included 5636 patients undergoing pancreaticoduodenectomy, 3922 patients with distal pancreatectomy and 315 undergoing central pancreatectomy.…”

“…The method of diagnosis of diabetes mellitus (DM) included fasting plasma glucose, oral glucose tolerance test, HbA1c and use of oral hypoglycaemic agents or insulin. Seven studies did not state how the diagnosis of DM was made …”

“…Forest plot of studies indicating incidence of new‐onset DM after each type of resection. A, Pancreaticoduodenectomy . Random effects model.…”

Targeted cyst wall puncture and aspiration during EUS-FNA increases the diagnostic yield of premalignant and malignant pancreatic cysts

“…Of all pancreaticoduodenectomies (n ϭ 547) performed at our institution from 2006 to 2010, 83 patients (15.1%) underwent this procedure for cystic lesions of the pancreas. 3 Pancreatic cysts can either be benign or neoplastic, and because the malignant potential varies depending on their subtype, there has been a significant effort to establish an accurate diagnosis by using minimally invasive techniques.…”

Non-Whipple Operations in the Management of Benign, Premalignant and Early Cancerous Duodenal Lesions

“…Unfortunately, PD is often associated with postoperative complications, since postoperative pancreatic fistula (POPF) is commonly encountered in these patients due to their soft pancreatic parenchyma and small pancreatic duct (8). In addition, pancreatic head resections are often associated with significant attenuation in pancreatic endocrine and exocrine function (9). Transduodenal ampullectomy and pancreaspreserving duodenectomy are operations that have been used for resecting duodenal lesions and have been reported to have a lower morbidity and mortality than PD (10).…”