Extended Gate Field Effect Transistor Based Sensor for Detection of Trace Amounts of Anti-Depressant Drug

Abstract

Citalopram hydrobromide (CP) is a selective serotonin reuptake inhibitor for the treatment of the depressive disorder. In this work, a novel label-free recognition method based on an extended gate fieldeffect transistor (EGFET) for selective determination of CP is investigated. A Pt electrode covered by a modified PVC membrane, as the sensing part, is connected to the gate of a MOSFET transducer. Two types of PVC membranes containing ion-pairs, CP ion and tetraphenylborate or phosphotungstate ions (with different percentages), are used in this study. The obtained results indicate that the PVC membrane containing 7 % CP-tetraphenylborate has the highest sensitivity, with a detection limit of 10 -12 M. The sensor exhibits two linear response ranges, in the ranges of 10 -11 -10 -7 M and 10 -6 -10 -2 M, characterized by different sensitivities. The proposed method shows clear advantages in terms of increased accuracy, sensitivity, precision, and selectivity. The sensor is successfully applied to assay citalopram in tablets. The features of simplicity in preparation, fast response, capability for the miniaturization, and easy operatory, make the sensor a promising candidate for future integrated lab-on-chip devices for pharmaceutical quality control measurements.INDEX TERMS Citalopram, ion selective field-effect transistor, extended gate field-effect transistor, PVC

An EGFET Based Common Source Amplifier as a Low-Frequency Instrumentation Amplifier for Sensitivity Measurement on RuO2 Lactic Acid Biosensor

“…The EGFET has some inherent advantages, such as a simpler manufacturing process, less influence by optical illumination, operating temperature, a one-time gate, not being susceptible to chemical contamination, and having good noise immunity. These advantages make EGFET a potential device structure in biotechnology so that it was less affected by light, easy to change the shape of the sensing film, and easy to relocate the sensing film of the sensing area [3].…”