Extended Hildebrand Approach: An Empirical Model for Solubility Prediction of Etodolac in 1,4-Dioxane and Water Mixtures

Extended Hildebrand solubility approach applied to some sulphonamides in propylene glycol + water mixtures

“…[18] Furthermore, it is still employed to evaluate the behaviour of drugs in several cosolvent mixtures. [20][21][22][23] On the other hand, it is remarkable that PG is one of the more employed co-solvent to develop liquid pharmaceutical dosage forms because of its solubilising and antimicrobial properties. [24,25] …”

Commentary On “Extended Hildebrand Approach: An Empirical Model for Solubility Prediction of Etodolac in 1,4-Dioxane and Water Mixtures”

“…The experimental densities reported by Rathi and Deshpande [1] do not appear to be of sufficient ''quality'' for excess molar volume calculations.…”

“…I cannot reproduce the solubility parameters of the binary solvent mixture that the authors give in Table 1 of their published paper [1].…”

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Abstract Several mathematical errors in the published paper by Rathi and Deshpande (J Solution Chem 43:1886-1903, 2014) are identified. The errors concern the incorrect conversion of mass fraction to volume fraction concentrations of 1,4-dioxane, the incorrect conversion of mole fraction solubilities to molar solubilities of Etodolac, and the incorrect calculation of the ideal mole fraction solubility of Etodolac.

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“…Published applications using the Hildebrand and extended Hildebrand approach normally use ideal volume fraction compositions for the initial solvent concentration. In Table 1 of the published paper [1] the authors report the solubility of Etodolac in terms of both mole fraction and molar (molÁL -1 ) solubilities. The two sets of experimental values are inconsistent with each other.…”