Extended maternal age at birth of last child and women’s longevity in the Long Life Family Study

Abstract

Objective This study investigated the association between maternal ages at birth of last child and the likelihood of survival to advanced ages. Methods A nested case-control study using Long Life Family Study (LLFS) data. Three hundred and eleven women who survived past the oldest 5th percentile of survival according to birth cohort matched life tables were identified as cases and 151 women who died at ages younger than the top 5th percentile of survival were identified as controls. A Bayesian mixed-effect logistic regression model was used to estimate the association between maternal age at birth of last child and exceptional longevity among these 462 women. Results A significant association for later maternal age was found whereby women who had their last child beyond the age of 33 years had twice the odds of survival to the top 5th percentile of survival of their birth cohorts compared to women who had their last child by age 29 (OR=2.08, 95%CI 1.13; 3.92 for age between 33 and 37 years and OR=1.92, 95% CI 1.03; 3.68 for older age). Conclusion The study supports the findings from other studies demonstrating a positive association between older maternal age and greater odds of the mother surviving to unusually old age.

Age-Based Reproductive Healthcare Stereotype Threat (HCST) as a Stressor Affecting Prenatal Mental Health in Pregnant Women of Advanced Maternal Age: Measurement, Process, Outcomes, and Interactions with Ethnicity/Race, SES, and Other Social Identities

“…This is both interesting and important because the ability to conceal older age may suggest a youthfulness that is not just skin deep. In fact, there are several lines of evidence linking youthfulness and longevity to fertility [1, 90–92]. Research on centenarians has demonstrated that women who have their last child after the age of 33 had twice the odds of living to age 95 than women who had their last child by age 30 or younger [90].…”

“…In fact, there are several lines of evidence linking youthfulness and longevity to fertility [1, 90–92]. Research on centenarians has demonstrated that women who have their last child after the age of 33 had twice the odds of living to age 95 than women who had their last child by age 30 or younger [90]. Patterns such as these are likely, at least in part, attributable to increased likelihood of delayed childbearing among more affluent women, who also have longer life expectancies because they are more affluent (i.e., the SES-health gradient).…”

Reproductive outcomes in pregnant women aged 35 or older: the role of individual repair capacity

“…Notably, haplogroup J has been shown to be also overrepresented in healthy individuals with extreme longevity, including healthy centenarians [61,62]. The latter may give some clue as to a potential cause of another phenomenon, namely, the fact that increased age of birth of last child may be associated with increased female longevity [63,64]. The authors of the latter two Reproductive outcomes and individual repair capacity studies specifically point out that the relationship seen between late childbirth and longevity may simply be an expression of generally slower ageing pattern.…”

Fertilität und Lebensdauer

“…Lebensjahr bekommen [25]. Tierversuche aktueller Studien zeigen, dass Bluttransfusionen von jüngeren auf ältere Mäuse sowie eine Schwangerschaft einen potenziellen Verjüngungseffekt bei älteren Individuen haben.…”