2020
DOI: 10.1093/pm/pnaa229
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Extended Perineural Analgesia After Hip and Knee Replacement When Buprenorphine-Clonidine-Dexamethasone Is Added to Bupivacaine: Preliminary Report from a Randomized Clinical Trial

Abstract: Objective We tested the hypothesis that buprenorphine-clonidine-dexamethasone (BCD) extends perineural analgesia compared with plain bupivacaine (BPV) nerve blocks used for hip and knee replacement surgery. Design Prospective, parallel-arms, randomized, double-blind trial. Setting A single veterans’ hospital. … Show more

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Cited by 10 publications
(3 citation statements)
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“…The time until the start of postoperative pain, no pain relief from blocks, the numbness wore off, and the worst postoperative pain were 26 vs 11 h, 32 vs 15 h, 37 vs 21 h and 39 vs 20 h, respectively. Regretfully, some aspects of this study model prevent a complete interpretation of the results [35]. For instance, mixed surgeries and surgical territories not entirely covered by the studied blocks make it impossible to correlate analgesia duration to block effectiveness.…”
Section: Unanswered Questionsmentioning
confidence: 99%
“…The time until the start of postoperative pain, no pain relief from blocks, the numbness wore off, and the worst postoperative pain were 26 vs 11 h, 32 vs 15 h, 37 vs 21 h and 39 vs 20 h, respectively. Regretfully, some aspects of this study model prevent a complete interpretation of the results [35]. For instance, mixed surgeries and surgical territories not entirely covered by the studied blocks make it impossible to correlate analgesia duration to block effectiveness.…”
Section: Unanswered Questionsmentioning
confidence: 99%
“…To prolong the duration of FNB, studies have explored the use of adjuvants such as dexmedetomidine, clonidine, ketamine, and glucocorticoids which have been added to local anesthetics 8–12 . Among these, long‐acting glucocorticoids have shown exciting results in extending the duration of FNB.…”
Section: Introductionmentioning
confidence: 99%
“…To prolong the duration of FNB, studies have explored the use of adjuvants such as dexmedetomidine, clonidine, ketamine, and glucocorticoids which have been added to local anesthetics. 8 , 9 , 10 , 11 , 12 Among these, long‐acting glucocorticoids have shown exciting results in extending the duration of FNB. When combined with the local anesthetic ropivacaine, dexamethasone prolongs the duration of analgesia after interscalene brachial plexus blocks, sciatic nerve blocks, and popliteal nerve blocks.…”
Section: Introductionmentioning
confidence: 99%