Extended Release of Theophylline Through Sodium Alginate Hydrogel Beads: Effect of Glycerol on Entrapment Efficiency, Drug Release

Ahirrao, Sapana; Gide, Paraag; Shrivastav, Birendra; Sharma, Pankaj Kumar

doi:10.1080/02726351.2013.809396

Cited by 16 publications

(20 citation statements)

References 12 publications

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“…Initially, physic-chemical characteristics of Alg-nanoHA hydrogels were addressed. Alg-nanoHA hydrogels, regardless of the nanoHA content, showed a considerable matrix strength, stiffness and permeability, typical of this type of gelation [34]. The characteristic absorption bands of Alg and nanoHA can be clearly seen in the ATR-FTIR spectra, indicating a successful entrapment of nanoHA into the Alg matrix, without chemical reactions occurring between them.…”

Section: Discussionmentioning

confidence: 86%

Alginate-nanohydroxyapatite hydrogel system: Optimizing the formulation for enhanced bone regeneration

Barros

Ferraz

Azeredo

et al. 2019

Materials Science and Engineering: C

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A B S T R A C TCeramic/polymer-based biocomposites have emerged as potential biomaterials to fill, replace, repair or regenerate injured or diseased bone, due to their outstanding features in terms of biocompatibility, bioactivity, injectability, and biodegradability. However, these properties can be dependent on the amount of ceramic component present in the polymer-based composite. Therefore, in the present study, the influence of nanohydroxyapatite content (30 to 70 wt%) on alginate-based hydrogels was studied in order to evaluate the best formulation for maximizing bone tissue regeneration. The composite system was characterized in terms of physic-chemical properties and biological response, with in vitro cytocompatibility assessment with human osteoblastic cells and ex vivo functional evaluation in embryonic chick segmental bone defects. The main morphological characteristics of the alginate network were not affected by the addition of nanohydroxyapatite. However, physic-chemical features, like water-swelling rate, stability at extreme pH values, apatite formation, and Ca 2+ release were nanoHA dose-dependent. Within in vitro cytocompatibility assays it was observed that hydrogels with nanoHA 30% content enhanced osteoblastic cells proliferation and expression of osteogenic transcription factors, while those with higher concentrations (50 and 70%) decreased the osteogenic cell response. Ex vivo data underlined the in vitro findings, revealing an enhanced collagenous deposition, trabecular bone formation and matrix mineralization with Alg-nanoHA30 composition, while compositions with higher nanoHA content induced a diminished bone tissue response.The outcomes of this study indicate that nanohydroxyapatite concentration plays a major role in physicchemical properties and biological response of the composite system and the optimization of the components ratio must be met to maximize bone tissue regeneration.

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Section: Discussionmentioning

confidence: 86%

Alginate-nanohydroxyapatite hydrogel system: Optimizing the formulation for enhanced bone regeneration

Barros

Ferraz

Azeredo

et al. 2019

Materials Science and Engineering: C

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“…Medical application of SAG was reported by Veerubhotla et al in their research of a 3D printed hydrogel-based cardiovascular stent [ 13 ]. Alginate-based beads have been widely investigated for the sustained and targeted delivery of various drugs in order to enhance bioavailability [ 14 , 15 , 16 , 17 ]. A natural source of phytochemicals has been explored to extend the medicinal applications in the treatment of a variety of human diseases and disorders.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Calcium-Alginate Beads of Apigenin: In Vitro Antitumor, Antibacterial, and Antioxidant Activities

et al. 2021

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The objective of this work was to develop sustained-release Ca-alginate beads of apigenin using sodium alginate, a natural polysaccharide. Six batches were prepared by applying the ionotropic gelation technique, wherein calcium chloride was used as a crosslinking agent. The beads were evaluated for particle size, drug loading, percentage yield, and in vitro drug release. Particle size was found to decrease, and drug entrapment efficiency was enhanced with an increase in the polymer concentration. The dissolution study showed sustained drug release from the apigenin-loaded alginate beads with an increase in the polymer proportion. Based on the dissolution profiles, BD6 formulation was optimized and characterized for FTIR, DSC, XRD, and SEM, results of which indicated successful development of apigenin-loaded Ca alginate beads. MTT assay demonstrated a potential anticancer effect against the breast cancer MCF-7 cell lines. The antimicrobial activity exhibited effective inhibition in the bacterial and fungal growth rate. The DPPH measurement revealed that the formulation had substantial antioxidant activity, with EC50 value slightly lowered compared to pure apigenin. A stability study demonstrated that the BD6 was stable with similar (f2) drug release profiles in harsh condition. In conclusion, alginate-based beads could be used for sustaining the drug release of poorly water-soluble apigenin while also improving in vitro antitumor, antimicrobial, and antioxidant activity.

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“…Nowadays, commercially available pectin‐based wound dressing materials have been used in the form of sheet and paste . Drug‐loaded pectin‐based materials have been developed in various research groups for oral administration and their drug release performances were determined at the specific pH of target organ . Their drug release performance has not been investigated at changing environmental conditions through healing process.…”

Section: Introductionmentioning

confidence: 99%

Theophylline‐loaded pectin‐based hydrogels. I. Effect of medium pH and preparation conditions on drug release profile

Güner

Cam

Arabacioglu-Kocaaga

et al. 2018

J of Applied Polymer Sci

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In this study, a series of theophylline‐loaded calcium pectin gel films were prepared in three different Ca+2 concentrations with three different methods for wound dressing applications. Drug release performance of the films were investigated in four different medium pH in order to mimic wound healing pH conditions. Hydrogel films were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, scanning electron microscopy and atomic force microscopy. Their absorbency (fluid handling), swelling behavior, dehydration rate, dispersion characteristic, dressing pH determination, water vapor permeability, oxygen permeability, surface contact angle, flexibility, Shore A hardness, mean mass per unit area and thickness were determined. The effect of the hydrogels on wound healing was evaluated with an in vitro wound healing assay. After evaluating all data, we suggested that the hydrogel film prepared with swelling method using 7% or 10% crosslinker and dried at 26 °C is more suitable for controlled drug release process. We showed that between pH 3.25 and 7.12 the form of the hydrogel did not change, and drug release was continuous. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46731.

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Extended Release of Theophylline Through Sodium Alginate Hydrogel Beads: Effect of Glycerol on Entrapment Efficiency, Drug Release

Cited by 16 publications

References 12 publications

Alginate-nanohydroxyapatite hydrogel system: Optimizing the formulation for enhanced bone regeneration

Alginate-nanohydroxyapatite hydrogel system: Optimizing the formulation for enhanced bone regeneration

Development and Characterization of Calcium-Alginate Beads of Apigenin: In Vitro Antitumor, Antibacterial, and Antioxidant Activities

Theophylline‐loaded pectin‐based hydrogels. I. Effect of medium pH and preparation conditions on drug release profile

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