2009
DOI: 10.1590/s1984-82502009000400029
|View full text |Cite
|
Sign up to set email alerts
|

Extended release promethazine HCl using acrylic polymers by freeze-drying and spray-drying techniques: formulation considerations

Abstract: The present study investigated a novel extended release system of promethazine hydrochloride (PHC) with acrylic polymers Eudragit RL100 and Eudragit S100 in different weight ratios (1:1 and 1: 5), and in combination (0.5+1.5), using freeze-drying and spray-drying techniques. Solid dispersions were characterized by Fourier-transformed infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), Powder X-ray diffractometry (PXRD), Nuclear magnetic resonance (NMR), Scanning electron microscopy (SEM), a… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
7
0

Year Published

2013
2013
2023
2023

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 7 publications
(7 citation statements)
references
References 24 publications
0
7
0
Order By: Relevance
“…Consequently, the biological activities and effects of these types of species on human health are obviously resulted of their nature and structural, electronic and topological properties. Hence, the interest to study another antihistaminic agent, in this case promethazine (PTZ) [10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33], which has two N–CH 3 groups (as diphenhydramine) linked to a chiral carbon and, as a consequence two enantiomeric S and R structures are expected for their three free base, cationic and hydrochloride species. PTZ hydrochloride is a drug used to treatment of nausea, vomiting, and dizziness associated with motion sickness and, besides possesses anti-pruritic, anti-allergic, anticholinergic, antihistaminic, central nervous system depressant, and with general anaesthetics effects.…”
Section: Introductionmentioning
confidence: 99%
“…Consequently, the biological activities and effects of these types of species on human health are obviously resulted of their nature and structural, electronic and topological properties. Hence, the interest to study another antihistaminic agent, in this case promethazine (PTZ) [10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33], which has two N–CH 3 groups (as diphenhydramine) linked to a chiral carbon and, as a consequence two enantiomeric S and R structures are expected for their three free base, cationic and hydrochloride species. PTZ hydrochloride is a drug used to treatment of nausea, vomiting, and dizziness associated with motion sickness and, besides possesses anti-pruritic, anti-allergic, anticholinergic, antihistaminic, central nervous system depressant, and with general anaesthetics effects.…”
Section: Introductionmentioning
confidence: 99%
“…The polymerization of one polymer is conducted in the presence of another polymer resulting in interpenetrating polymer networks. Polymer electrolytes are prepared using this technique [59]. The preparation method of the blend polymer can impact the miscibility between two or more polymers than their properties.…”
Section: In-situ Polymerizationmentioning
confidence: 99%
“…There were critical contrasts in dissolution profiles for unadulterated medication, corporal blend, and lyophilized blend. Accounting DE10 min esteems, dissolution pace for Pilocarpine was expanded in the request: unadulterated medication less than 1:1 corporal blend less than 1:1 lyophilized blend proposing that dissolution flow is affected by lyophilization technique used to set up incorporation complex [24]. Following 4 min, the level of unadulterated medication broken down was 41.23% in any case, the rate medicates dissolution from the physical blend, lyophilized complex was 69.03%, and 89.23% individually.…”
Section: Dissolution Studymentioning
confidence: 99%