Background
Extended spectrum cephalosporin-resistant Enterobacterales (ESCrE) are an increasingly important cause of community-onset urinary tract infections (UTIs), including recurrent infections. We evaluated risk factors for recurrence among patients with community-onset ESCrE UTI.
Methods
This retrospective cohort study included adults with community-onset ESCrE UTI in Duke University Health System from April 2018 through December 2021. ESCrE UTI recurrence by the same species was assessed 14 to 180 days (i.e. 6 months) after completion of antibiotic treatment. We evaluated the relationships between candidate risk factors and time to recurrence using Cox proportional hazards regression models.
Results
Among 1,347 patients with community-onset ESCrE UTI, 202 (15.0%) experienced recurrent infection during the 6-month follow-up period. Independent risk factors for recurrence included neurogenic bladder (adjusted HR [aHR] = 1.8, 95% CI = 1.2 to 2.6, p = 0.005), prior history of UTI (aHR = 2.4, 95% CI = 1.7 to 3.3, p < 0.001), and fluoroquinolone non-susceptibility of the index UTI (aHR = 1.5, 95% CI = 1.1 to 2.1, p = 0.02). Klebsiella pneumoniae infection was associated with recurrence in univariate analysis (HR = 1.6, 95% CI = 1.1 to 2.1, p = 0.007) but not multivariate analysis (aHR = 1.4, 95% CI = 1.0 to 1.9, p = 0.06). Inappropriate initial or definitive antibiotic therapy were not predictive of ESCrE UTI recurrence.
Conclusions
Recurrence of community-onset ESCrE UTI was common and associated with several patient and pathogen-level risk factors. Future studies should evaluate microbial risk factors for recurrence and improve the management of ESCrE UTI.