Extended-spectrum beta-lactamase-producing Enterobacteriacae: unexpected low prevalence of carriage in elderly French residents

Bertrand, Xavier; Amara, Marlène; Sauget, Marlène; Clément, Marie-Caroline; Talon, D.; Valentin, Anne-Sophie; Quentin, Roland; Mee-Marquet, Nathalie van der

doi:10.1093/ageing/afr173

Cited by 8 publications

(10 citation statements)

References 20 publications

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“…14 However, the overall rate of 10% of residents carrying ESBLE masks different situations in NHs. Similar to observations in almost all NHs participating in the study in 2010, 12 the ESBLE carriage rate among residents of one-third of the NHs participating in this study was low. In these NHs, the combination of a low rate of ESBLE carriage by residents and the absence of similar isolates shared by different residents argues that the spread of ESBLE in these NHs is controlled.…”

Section: Discussionsupporting

confidence: 88%

“…We demonstrate a high rate of ESBLE carriage (10%) among the residents enrolled, and this carriage rate is much higher than that observed by our first study in 2010. 12 Although the 2 studies are not directly comparable because of differences between the participating NHs, the results we report indicate an increasing trend and a rapid spread of ESBLE in the NHs of our region. Our results are concordant with reports of increasing trends for both invasive infections associated with ESBLE in HCIs 13 and carriage in the community setting.…”

Section: Discussioncontrasting

confidence: 50%

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Extended-Spectrumβ-Lactamase–Producing Enterobacteriaceae in French Nursing Homes: An Association between High Carriage Rate among Residents, Environmental Contamination, Poor Conformity with Good Hygiene Practice, and Putative Resident-to-Resident Transmission

Cochard

Aubier

Quentin

et al. 2014

Infect. Control Hosp. Epidemiol.

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Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 50%

Extended-Spectrumβ-Lactamase–Producing Enterobacteriaceae in French Nursing Homes: An Association between High Carriage Rate among Residents, Environmental Contamination, Poor Conformity with Good Hygiene Practice, and Putative Resident-to-Resident Transmission

Cochard

Aubier

Quentin

et al. 2014

Infect. Control Hosp. Epidemiol.

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“…There is no published correlation between constipation and faecal carriage, but constipation is a known risk factor for development of UTIs that subsequently can affect the faecal carriage. Exposure to any antibiotic in the 3 months prior to the faecal sampling is associated with a higher detection of ESBL-producing organism; such association was demonstrated in many studies [ 14 – 16 , 21 , 32 , 33 ]. Several studies identify quinolone intake, and specifically ciprofloxacin, as a risk factor for the development or persistence of ESBL faecal carriage [ 12 , 26 , 34 ].…”

Section: Discussionmentioning

confidence: 89%

“…Prevalence in long-term care facilities and NHs, in nonoutbreak settings, varied significantly from 1.9% in France [17/877, 2012] [ 21 ] to 64% in Italy [71/111, 2009] [ 15 ] and 40.5% in UK [119/294, 2009] [ 14 ]. The particularly low prevalence in France can be attributed to poor screening method as stated in the study itself.…”

Section: Discussionmentioning

confidence: 99%

Extended Spectrum Beta‐Lactamase Carriage State among Elderly Nursing Home Residents in Beirut

Jallad

Naoufal

Irani

et al. 2015

The Scientific World Journal

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Introduction. ESBL-producing Enterobacteriaceae can cause severe infections, but they are also isolated from the stool of asymptomatic subjects. Faecal carriage of such organism is poorly understood. Methods. First phase of the study was cross-sectional with prevalence and epidemiology of ESBL faecal carriage in two nursing homes in Beirut: 57 residents in the first (NH1) and 151 residents in the second (NH2). In second phase, faecal swabs from cohort of NH1 residents were examined for carriage at six-week intervals over three-month period. Residents' charts were reviewed to assess carriage risk factors. Results. Over 3 consecutive samplings at NH1, 81% of residents were at least one-time carriers with 50% at the first round, 60.4% at the second, and 74.5% at the last one. At NH2, 68.2% of residents were carriers. Constipation (in NH1) and antibiotic intake (in NH2) were significantly associated with higher ESBL faecal carriage while the length of stay at the nursing home (in NH2) was associated with less carriage. Conclusion. Faecal carriage of ESBL-producing Enterobacteriaceae is high among nursing home patients in Beirut. The rate of carriage changes rapidly and significantly over time either with multiple factors playing a possible role like outbreak spreading, antibiotic, and health care system exposure.

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“…Previous studies performed in other European countries have reported a broad range of prevalence of MDRO. For example, in Northern Ireland and in Italy, high rates of asymptomatic carriage of ESBLE were reported (41 and 64%, respectively) while recent study in Sweden and in France, prevalence rates of 3% or lower have been reported [9], [14], [15], [16]. Variations in the screening sampling sites and in the microbiological methods, differences in the definitions of criteria for the targeted microorganisms, differences in the population case-mix and in local practices as well as true epidemiological variations may probably altogether explain this large variability across countries.…”

Section: Discussionmentioning

confidence: 97%

Epidemiology of Multidrug-Resistant Microorganisms among Nursing Home Residents in Belgium

et al. 2013

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ObjectivesA national survey was conducted to determine the prevalence and risk factors of methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum β-lactamases-producing Enterobacteriaceae (ESBLE) and vancomycin-resistant enterococci (VRE) among nursing home residents in Belgium.MethodsA random stratified, national prevalence survey was conducted in nursing home residents who were screened for carriage of ESBLE, MRSA and VRE by multisite enriched culture. Characteristics of nursing homes and residents were collected by a questionnaire survey and were analysed by multilevel logistic regression analysis.ResultsOf 2791 screened residents in 60 participating nursing home, the weighted prevalence of ESBLE and MRSA carriage were 6.2% (range: 0 to 20%) and 12.2% (range: 0 to 36%), respectively. No cases of VRE were found. No relationship was found between ESBLE and MRSA prevalence rates within nursing homes and the rate of co-colonization was very low (0.8%). Geographical variations in prevalence of MRSA and ESBLE and in distribution of ESBL types in nursing home residents paralleled that of acute hospitals. Risk factors of ESBLE carriage included previously known ESBLE carriage, male gender, a low level of mobility and previous antibiotic exposure. Risk factors for MRSA colonization were: previously known MRSA carriage, skin lesions, a low functional status and antacid use.ConclusionsA low prevalence of ESBLE carriage was found in nursing home residents in Belgium. The prevalence of MRSA carriage decreased substantially in comparison to a similar survey conducted in 2005. A low functional status appeared as a common factor for ESBLE and MRSA carriage. Previous exposure to antibiotics was a strong predictor of ESBLE colonization while increased clustering of MRSA carriage suggested the importance of cross-transmission within nursing homes for this organism. These results emphasize the need for global coordination of the surveillance of MDRO within and between nursing homes and hospitals.

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Extended-spectrum beta-lactamase-producing Enterobacteriacae: unexpected low prevalence of carriage in elderly French residents

Cited by 8 publications

References 20 publications

Extended-Spectrumβ-Lactamase–Producing Enterobacteriaceae in French Nursing Homes: An Association between High Carriage Rate among Residents, Environmental Contamination, Poor Conformity with Good Hygiene Practice, and Putative Resident-to-Resident Transmission

Extended-Spectrumβ-Lactamase–Producing Enterobacteriaceae in French Nursing Homes: An Association between High Carriage Rate among Residents, Environmental Contamination, Poor Conformity with Good Hygiene Practice, and Putative Resident-to-Resident Transmission

Extended Spectrum Beta‐Lactamase Carriage State among Elderly Nursing Home Residents in Beirut

Epidemiology of Multidrug-Resistant Microorganisms among Nursing Home Residents in Belgium

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