Extended-Spectrum-β-Lactamase, AmpC, and Carbapenemase Issues

Thomson, Kenneth S.

doi:10.1128/jcm.00219-10

Cited by 332 publications

(285 citation statements)

References 57 publications

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“…(Barlow and Hall, 2002;Johnson, and O'Bryan, 2000;Thomson, 2010) In our study prevalence of chromosomal AmpC was 2.33% (28/1200) in comparison to 4.00 % (48/1200) plasmid mediated. This is statistically significant at p<0.05(0.019734).…”

Section: Figure2 Ampc Disk Testsupporting

confidence: 45%

Detection of Inducible and Non-inducible (constitutive) AmpC β-lactamase-producing Gram-Negative Bacteria among Family Enterobacteriaceae by Two Phenotypic Methods-Disk Antagonism Test (DAT) and AmpC disk Test at a Tertiary Care Hospital, Himachal Pradesh, India

Ashok¹,

Jaryal²,

Thakur³

et al. 2016

Int.J.Curr.Microbiol.App.Sci

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Section: Figure2 Ampc Disk Testsupporting

confidence: 45%

Detection of Inducible and Non-inducible (constitutive) AmpC β-lactamase-producing Gram-Negative Bacteria among Family Enterobacteriaceae by Two Phenotypic Methods-Disk Antagonism Test (DAT) and AmpC disk Test at a Tertiary Care Hospital, Himachal Pradesh, India

Ashok¹,

Jaryal²,

Thakur³

et al. 2016

Int.J.Curr.Microbiol.App.Sci

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“…Sebbene i ceppi batterici or ora citati rappresentino i principali produttori di ß-lattamasi a spettro esteso in Europa, studi recenti hanno evidenziato la presenza di ESBL anche in alcuni ceppi emergenti di Salmonella enterica isolati in Italia in cui è stata identificata la presenza del gene bla CTX-M-1 (17). La diffusione dei ceppi produttori di ESBL ha portato, nel tempo, ad un aumento dell'utilizzo dei carbapenemi per il trattamento delle infezioni da Enterobacteriaceae contro la maggior parte delle quali essi mantengono ancora, una buona efficacia (21). Tuttavia l'incremento nell'uso dei carbapenemi ha, a sua volta, creato una pressione selettiva, con il risultato di indurre la diffusione di ceppi resistenti in grado di produrre diverse classi di enzimi carbapenemici come MBL, OXA, KPC e GES sia tra le Enterobacteriaceae stessi, che in numerosi ceppi di P. aeruginosa e A. baumannii (19).…”

Section: Discussionunclassified

EPIDEMIOLOGICAL OBSERVATORY: spreading of ESBL and carbapenemase positive strains in the period between January 2007 - June 2012, at the Hospital - University Campus - Hospital “Luigi Sacco” in Milan

Tocalli¹,

Boselli²,

Rimoldi³

et al. 2012

Microbiol Med

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“…Extended-spectrum beta-lactamases (ESBLs) are clavulanate susceptible enzymes that hydrolyze penicillins, expanded-spectrum cephalosporins, and monobactams and are commonly inhibited by beta-lactamase inhibitors such as clavulanic acid, sulbactam, and tazobactam [1]. Ambler Class C (AmpC) beta-lactamases are cephalosporinases that are poorly inhibited by clavulanic acid.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antibacterial Activity of Neem Leaves on Extended-Spectrum Beta-Lactamase and Ambler Class C Coproducers From Skin and Soft-Tissue Infections.

Shah¹,

Williamson

2018

Asian J Pharm Clin Res

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Objective: Clinical isolates coproducing extended-spectrum beta-lactamase (ESBL) and Ambler Class C (AmpC) beta-lactamase are a therapeutic challenge. The aim of the present study was to evaluate the antibacterial activity of Azadirachta indica methanolic leaf extract against lactose fermenting coproducers of ESBL and AmpC isolated from skin and soft-tissue infections (SSTIs). Methods:A total of 88 non-duplicate lactose fermenting strains isolated from SSTIs specimens were tested for their antibiotic susceptibility pattern by Kirby-Bauer disk diffusion method. Ceftazidime and cefoxitin-resistant strains were screened for coproduction of ESBL and AmpC beta-lactamase by phenotypic confirmatory disc diffusion test and E-test. Antibacterial activity of methanolic neem leaf (NLM) extract was examined by the disc diffusion method and the minimum inhibitory concentration (MIC) of NLM was determined by the agar dilution technique.Results: Thirty-seven lactose fermenting strains were confirmed to be coproducers of ESBL and AmpC, out of which 27 were Escherichia coli and 10 were Klebsiella spp. The nimbin content in the neem leaf extract was found to be 0.007% (w/w) by high-performance liquid chromatography (HPLC) analysis. The NLM extract showed inhibitory activity against all the 37 lactose fermenting isolates from SSTIs, coproducing ESBL and AmpC. The MIC of NLM extract was determined to be in the range of 4-8% (40-80 mg/ml) against the selected isolates. Conclusion:It can be stated that NLM extract might have therapeutic significance against coproducers of ESBL and AmpC beta-lactamase isolated from SSTIs.

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Extended-Spectrum-β-Lactamase, AmpC, and Carbapenemase Issues

Cited by 332 publications

References 57 publications

Detection of Inducible and Non-inducible (constitutive) AmpC β-lactamase-producing Gram-Negative Bacteria among Family Enterobacteriaceae by Two Phenotypic Methods-Disk Antagonism Test (DAT) and AmpC disk Test at a Tertiary Care Hospital, Himachal Pradesh, India

Detection of Inducible and Non-inducible (constitutive) AmpC β-lactamase-producing Gram-Negative Bacteria among Family Enterobacteriaceae by Two Phenotypic Methods-Disk Antagonism Test (DAT) and AmpC disk Test at a Tertiary Care Hospital, Himachal Pradesh, India

EPIDEMIOLOGICAL OBSERVATORY: spreading of ESBL and carbapenemase positive strains in the period between January 2007 - June 2012, at the Hospital - University Campus - Hospital “Luigi Sacco” in Milan

In Vitro Antibacterial Activity of Neem Leaves on Extended-Spectrum Beta-Lactamase and Ambler Class C Coproducers From Skin and Soft-Tissue Infections.

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