Extended-Spectrum β-Lactamase Enzymes in Clinical Isolates of<i>Enterobacter</i>Species from Lagos, Nigeria

Aibinu, I.; Ohaegbulam, V.C.; Adenipekun, E.; Ogunsola, F.T.; Odugbemi, T; Mee, Brian

doi:10.1128/jcm.41.5.2197-2200.2003

Cited by 74 publications

(72 citation statements)

References 30 publications

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“…This is higher than the 2.7 %, 15.8 %, 20 % and 28.9 % reported in previous studies in Nigeria [8,12,18,19]. Previous use of antimi-crobial agents, especially cephalosporins and fluoroquinolones, has been reported as risk factors associated with emergence of ESBL [6,7].…”

Section: Discussioncontrasting

confidence: 52%

“…The finding that Gram negative bacteria from wound and urine specimens produce ESBL agrees with previous reports [5,19]. Enterobacter species were the most prevalent producers of ESBL generally and from both wounds and urinary tract infections as previously reported from this study locality [12] and disagrees with others which reported Escherichia coli and Klebsiella species as the predominant producers [20].…”

Section: Discussioncontrasting

confidence: 40%

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Extended-Spectrum Beta-Lactamase (ESBL)–Producing Gram-negative Isolates from Urine and Wound Specimens in a Tertiary Health Facility in Southern Nigeria

Ogefere¹,

Aigbiremwen²,

Omoregie³

2015

Trop. J. Pharm Res

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Section: Discussioncontrasting

confidence: 52%

Section: Discussioncontrasting

confidence: 40%

Extended-Spectrum Beta-Lactamase (ESBL)–Producing Gram-negative Isolates from Urine and Wound Specimens in a Tertiary Health Facility in Southern Nigeria

Ogefere¹,

Aigbiremwen²,

Omoregie³

2015

Trop. J. Pharm Res

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“…was 12.73% which was different from the other results in Pakistan (50%, 14.93%) (21,22), Nigeria (37.5%) (10) and Pennsylvania, the USA (33.33%) (9).…”

Section: Discussioncontrasting

confidence: 54%

Emergence of blaCTX-M-15 Gene and Its Transferability in Enterobacter spp. Isolated From the Hospitals of Tehran, Iran

Rizi¹,

Peerayeh²,

Bakhshi³

et al. 2015

Avicenna J Clin Microbiol Infect

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Background: Enterobacter spp. is increasingly recognized as an important nosocomial pathogen and implicated in many episodes of hospital acquired infections. Objectives: The current study aimed to describe distribution and transferability of bla CTX-M-15 gene, and the antibiotic susceptibility pattern in the clinical isolates of Enterobacter spp. Materials and Methods: A total of 110 Enterobacter isolates were collected from five hospitals in Tehran, Iran from May 2012 to April 2013. Enterobacter species were identified by API 20E system. Antibacterial susceptibility was determined by disk diffusion method, and extended spectrum beta lactamase (ESBL) production was confirmed by combined disk method. The bla CTX-M-15 gene was identified by PCR with specific primers. The transferability of the bla CTX-M-15 was tested by conjugation with broth matting method. Results: The prevalence of Enterobacter species was E. cloacae (78.2 %), E. aerogenes (6.13 %) and E. sakazakii (8.2%). They were from different clinical sources. Maximal resistance in Enterobacter isolates was noticed against Augmentin®, trimethoprim -sulfamethoxazole and cefoxitin 75.5%, 64.5%, and 59.1%, respectively. Fourteen isolates, showed ESBL phenotype. The bla CTX-M-15 gene frequency in Enterobacter isolates was 11.8%. Three conjugative plasmids containing bla CTX-M-15 were found in one Enterobacter isolate.

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“…In Nigeria, these enzymes have been reported in Enterobacter species from human patients in Lagos (1).…”

Section: Introductionmentioning

confidence: 99%

Extended-spectrum beta-lactamase production among ampicillin-resistant Escherichia coli strains from chicken in Enugu State, Nigeria

Chah¹,

Oboegbulem²

2007

Braz. J. Microbiol.

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One hundred and seventy-two ampicillin-resistant E. coli strains isolated from commercial chickens in Enugu State, Nigeria, were screened for beta-lactamase production using the broth method with nitrocefin ® as the chromogenic cephalosporin to detect enzyme production. Beta-lactamase producing strains were further examined for extended-spectrum beta-lactamase (ESBL) production using the Oxoid combination discs method. One hundred and seventy (98.8%) of the 172 ampicillin-resistant E. coli strains produced beta-lactamase enzyme. Sixteen (9.4%) beta-lactamase producers were phenotypically confirmed to produce ESBLs. Six of the ESBL producing strains were only detected with ceftazidime versus ceftazidime/clavulanate combination while ten of the ESBL producers were detected with cefotaxime versus cefotaxime/clavulanate combination. Chicken may serve as a reservoir of ESBL-producing E. coli strains which could be transferred to man and other animals.

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Extended-Spectrum β-Lactamase Enzymes in Clinical Isolates ofEnterobacterSpecies from Lagos, Nigeria

Cited by 74 publications

References 30 publications

Extended-Spectrum Beta-Lactamase (ESBL)–Producing Gram-negative Isolates from Urine and Wound Specimens in a Tertiary Health Facility in Southern Nigeria

Extended-Spectrum Beta-Lactamase (ESBL)–Producing Gram-negative Isolates from Urine and Wound Specimens in a Tertiary Health Facility in Southern Nigeria

Emergence of blaCTX-M-15 Gene and Its Transferability in Enterobacter spp. Isolated From the Hospitals of Tehran, Iran

Extended-spectrum beta-lactamase production among ampicillin-resistant Escherichia coli strains from chicken in Enugu State, Nigeria

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