Extended-spectrum β-lactamase-producing Escherichia coli strains in the feces of carriers contribute substantially to urinary tract infections in these patients

Niki, Marie; Hirai, Itaru; Yoshinaga, Aya; Ulzii-Orshikh, L.; Nakata, Atsuo; Yamamoto, Akira; Yamamoto, Miku; Yamamoto, Yoshimasa

doi:10.1007/s15010-011-0128-2

Cited by 24 publications

(14 citation statements)

References 17 publications

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“…Individuals colonized with certain strains of ESBLPE appear more likely to suffer ESBLPE infection [5], while most patients with ESBLPE-associated infection are colonized with ESBLPE [6]. Moreover, household contacts of ESBLPE-infected patients are subject to increased risk of colonization by ESBLPE [6].…”

Section: Discussionmentioning

confidence: 99%

“…Intestinal colonization with ESBLPE provides a reservoir of bacteria that may cause infection of the host [5], be transmitted to others [6], and transmit resistance genes to other bacteria across species boundaries [7]. High rates of intestinal colonization with ESBLPE have been reported from many regions [8]–[10], although the prevalence in most communities in the United States is unknown.…”

Section: Introductionmentioning

confidence: 99%

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Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae in International Travelers and Non-Travelers in New York City

Weisenberg

Mediavilla²,

Chen³

et al. 2012

PLoS ONE

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BackgroundWe performed this study 1) to determine the prevalence of community-associated extended spectrum beta-lactamase producing Enterobacteriaceae (ESBLPE) colonization and infection in New York City (NYC); 2) to determine the prevalence of newly-acquired ESBLPE during travel; 3) to look for similarilties in contemporaneous hospital-associated bloodstream ESBLPE and travel-associated ESBLPE.MethodsSubjects were recruited from a travel medicine practice and consented to submit pre- and post-travel stools, which were assessed for the presence of ESBLPE. Pre-travel stools and stools submitted for culture were used to estimate the prevalence of community-associated ESBLPE. The prevalence of ESBLPE-associated urinary tract infections was calculated from available retrospective data. Hospital-associated ESBLPE were acquired from saved bloodstream isolates. All ESBLPE underwent multilocus sequence typing (MLST) and ESBL characterization.ResultsOne of 60 (1.7%) pre- or non-travel associated stool was colonized with ESBLPE. Among community-associated urine specimens, 1.3% of Escherichia coli and 1.4% of Klebsiella pneumoniae were identified as ESBLPE. Seven of 28 travelers (25.0%) acquired a new ESBLPE during travel. No similarities were found between travel-associated ESBLPE and hospital-associated ESBLPE. A range of imported ESBL genes were found, including CTX-M-14 and CTX-15.ConclusionESBL colonization and infection were relatively low during the study period in NYC. A signficant minority of travelers acquired new ESBLPE during travel.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae in International Travelers and Non-Travelers in New York City

Weisenberg

Mediavilla²,

Chen³

et al. 2012

PLoS ONE

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“…When uptake of these isolates takes place (through consumption or handling of contaminated food), these isolates are able to share their ESBL/AmpC genes with other bacteria in the gastro-intestinal tract by plasmid-transfer, especially when selecting compounds, like beta-lactam antibiotics are administered [6]. ESBL/AmpC producing bacteria in the gastro-intestinal tract can act as a source for infections in other parts of the body, like the urinary tract [7]. Treatment efficacy may be impaired due to the multi-drug resistant features often found in these organisms [1].…”

Section: Introductionmentioning

confidence: 99%

Presence of ESBL/AmpC -Producing Escherichia coli in the Broiler Production Pyramid: A Descriptive Study

Dierikx

Goot

Smith³

et al. 2013

PLoS ONE

183

162

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Broilers and broiler meat products are highly contaminated with extended spectrum beta-lactamase (ESBL) or plasmid-mediated AmpC beta-lactamase producing Escherichia coli and are considered to be a source for human infections. Both horizontal and vertical transmission might play a role in the presence of these strains in broilers. As not much is known about the presence of these strains in the whole production pyramid, the epidemiology of ESBL/AmpC-producing E. coli in the Dutch broiler production pyramid was examined. Cloacal swabs of Grandparent stock (GPS) birds (one−/two-days (breed A and B), 18 and 31 weeks old (breed A)), one-day old Parent stock birds (breed A and B) and broiler chickens of increasing age (breed A) were selectively cultured to detect ESBL/AmpC-producing isolates. ESBL/AmpC-producing isolates were found at all levels in the broiler production pyramid in both broiler breeds examined. Prevalence was already relatively high at the top of the broiler production pyramid. At broiler farms ESBL/AmpC producing E. coli were still present in the environment of the poultry house after cleaning and disinfection. Feed samples taken in the poultry house also became contaminated with ESBL/AmpC producing E. coli after one or more production weeks. The prevalence of ESBL/AmpC-positive birds at broiler farms increased within the first week from 0–24% to 96–100% independent of the use of antibiotics and stayed 100% until slaughter. In GPS breed A, prevalence at 2 days, 18 weeks and 31 weeks stayed below 50% except when beta-lactam antibiotics were administered. In that case prevalence increased to 100%. Interventions minimizing ESBL/AmpC contamination in broilers should focus on preventing horizontal and vertical spread, especially in relation to broiler production farms.

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“…The high prevalence of these bacteria in healthy carriers may be an important source of community-acquired infections, including urinary tract infections (UTIs). However, whether these ESBL-producing bacteria can be causative infectious agents in the carrier has not yet been confirmed (Niki et al, 2011). Clinical strains of Escherichia coli producing ESBLs have high prevalence of ESBL-producing Enterobacteriaceae in hospitals in African countries including Morocco, South Africa and Nigeria (Iabadene et al, 2008;Sekhsokh et al, 2008;Pitout et al, 1998;Aibinu et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Phenotypic Characterization and Comparative Study on ESBL-producing E. coli of Clinical Origin

Emmanuel¹

2016

ijSciences

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Extended-spectrum β-lactamases (ESBLs) continue to be a major challenge in clinical setups worldwide, conferring resistance to the expanded-spectrum cephalosporins. The present study focused on the prevalence of ESBL-producing E. coli clinical isolates among patients diagnosed of Wound and Urinary Tract Infections attending Federal Teaching Hospital Abakaliki. A total of one hundred and ninety two clinical isolates of E. coli was studied for their susceptibility patterns to cephalosporin antibiotics and detection of ESBL producers was carried out by double disc synergy test (DDST) and Brilliance ESBL Agar. Of the 192 isolates tested for their antibiogram, 19(9.9%), 41(21.4%), 132(68.7%); 48(25.0%) and 144(75.0%) isolates were from wound, high virginal swab, urine, male and female respectively. The isolates showed higher susceptibility to cefepime (a 4th-generation cephalosporin) with percentage susceptibility of 78.9, 85.4 and 73.5 to the isolates from wound, HVS and urine respectively. Higher resistance was recorded among the 3 rd-generation cephalosporins which include Cefotaxime (63.4%), Ceftriaxone (57.9%), and Cefpodoxime (73.7%). Among the resistant isolates of E. coli, 20 isolates were phenotypically confirmed ESBL producers by the DDST and Brilliance ESBL Agar methods. Ten (10) ESBL producing E. coli was confirmed using DDST method whereas 15 ESBL producing E. coli was confirmed using the Brilliance ESBL Agar. Brilliance ESBL Agar was found to be better than DDST in the detection of ESBLs. Continuous monitoring of drug resistance and regulating the use of cephalosporin drugs in our hospitals is vital for proper infectious disease management and treatment.

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Extended-spectrum β-lactamase-producing Escherichia coli strains in the feces of carriers contribute substantially to urinary tract infections in these patients

Abstract: The ESBL-producing E. coli in carriers can cause UTIs.

Cited by 24 publications

References 17 publications

Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae in International Travelers and Non-Travelers in New York City

Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae in International Travelers and Non-Travelers in New York City

Presence of ESBL/AmpC -Producing Escherichia coli in the Broiler Production Pyramid: A Descriptive Study

Phenotypic Characterization and Comparative Study on ESBL-producing E. coli of Clinical Origin

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