Extended storage of platelet‐rich plasma–prepared platelet concentrates in plasma or Plasmalyte

Slichter, Sherrill J.; Bolgiano, Doug; Corson, Jill; Jones, Martin; Christoffel, Todd

doi:10.1111/j.1537-2995.2010.02669.x

Cited by 22 publications

(19 citation statements)

References 38 publications

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“…The storage time for all of our studies considered the first day of PLT storage as within the whole blood that was maintained at room temperature for 22 to 24 hours before PC preparation on the day after whole blood collection. These results are the same as we previously reported for PRP‐stored PCs …”

Section: Discussionsupporting

confidence: 92%

“…We have previously reported the in vivo and in vitro results of extended stored PRP PCs stored in plasma or 80% Plasmalyte . In this study, we report similar data for extended storage of BC PCs stored in plasma or Plasmalyte.…”

supporting

confidence: 81%

“…In addition, 6‐day storage studies were also done with PRP‐prepared PLTs stored in 65% Plasmalyte and 35% residual plasma. The PRP PLTs were prepared as previously described except that the whole blood was stored at 22°C for 22 ± 2 hours before preparation of the PCs …”

Section: Resultsmentioning

confidence: 99%

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Extended storage of buffy coat platelet concentrates in plasma or a platelet additive solution

et al. 2014

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Background Platelet concentrates prepared from whole blood in the U.S. are made using the platelet-rich-plasma (PRP) method. The platelet concentrates must be made within 8 hours of blood collection and stored for only 5 days. In Europe and Canada, platelet concentrates are made using the buffy-coat (BC) method from whole blood held overnight at 22°C and storage times may be up to 7 days. Our studies were designed to determine how long BC platelets can be stored in plasma or Plasmalyte while meeting the FDA’s post-storage viability criteria. Study Design, Materials, And Methods Normal subjects donated whole blood that was stored at 22°C for 22 ± 2 hours prior to preparation of BC platelets. Platelets were stored for 5 to 8 days in either plasma or Plasmalyte concentrations of 65% or 80%. Radiolabeled autologous stored versus fresh platelet recoveries and survivals were assessed as well as post-storage in vitro assays. Results BC platelets stored in either plasma or 65% Plasmalyte met FDA post-storage platelet recovery criteria for 7 days but survivals for only 6 days, while storage in 80% Plasmalyte gave very poor results. Both stored platelet recoveries and survivals correlated with the same donor’s fresh results, but the correlation was much stronger between recoveries than survivals. In vitro measures of extent of shape change, morphology score, and pH best predicted post-storage platelet recoveries, while annexin V binding best predicted platelet survivals. Conclusion BC platelets stored in either plasma or 65% Plasmalyte meet FDA’s post-storage viability criteria for 6 days.

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Section: Discussionsupporting

confidence: 92%

supporting

confidence: 81%

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Extended storage of buffy coat platelet concentrates in plasma or a platelet additive solution

et al. 2014

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“…It is used for fluid resuscitation, hydration in seriously ill patients (6,11,17,20), and extended storage of platelets or peripheral blood stem cell products (3,16,19).…”

mentioning

confidence: 99%

Galactomannan Antigenemia after Infusion of Gluconate-Containing Plasma-Lyte

Petraitienė

Petraitis

Witt³

et al. 2011

J Clin Microbiol

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We demonstrated that sodium gluconate was the factor causing false-positive galactomannan (GM) antigenemia of Plasma-Lyte hydration solution. Infusion of sodium gluconate-containing solution but not gluconate-free Plasma-Lyte resulted in positive serum GM antigenemia. Serum GM concentrations also correlated with the volume and in vitro concentrations of GM within gluconate-containing solutions of infused Plasma-Lyte.

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“…9,10 The possibilities for extending the shelf life of PLT products have been examined. 31 However, our findings indicate that a substantial reduction in PLT secretory capacity and aggregability have already occurred within 5 days of storage. As such, the benefits of further extending the shelf life of current PLT products are questionable.…”

Section: Commentmentioning

confidence: 53%

Use of a Cytokine-Release Assay to Demonstrate Loss of Platelet Secretory Capacity During Blood Bank Processing and Storage

Tormey

Stack²

2014

Archives of Pathology &Amp; Laboratory Medicine

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Extended storage of platelet‐rich plasma–prepared platelet concentrates in plasma or Plasmalyte

Cited by 22 publications

References 38 publications

Extended storage of buffy coat platelet concentrates in plasma or a platelet additive solution

Extended storage of buffy coat platelet concentrates in plasma or a platelet additive solution

Galactomannan Antigenemia after Infusion of Gluconate-Containing Plasma-Lyte

Use of a Cytokine-Release Assay to Demonstrate Loss of Platelet Secretory Capacity During Blood Bank Processing and Storage

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