Peripherally inserted central catheters (PICCs) play a critical role in the infusion of parenteral nutrition, chemotherapy and intravenous fluids for the increased safety and efficacy for long-term use. However, during the insertion and management of PICCs, there are still some PICC-related complications need to be reduced as much as possible for both operators and researchers. In this case, the tunneled-PICC provides a new "a nedesl subcutaneous route" technology for PICC application. This article reviews the principle and characteristics of tunneled-PICC. Tunneled PICCs, seems to be a safe option and easy to perform as an alternative to standard placement for its advantages of the better exit location, reduced incidences of thrombosis and infection, reduced the shift rate as well as extended retention time. However, more research on the standard tunneling technique and large-scale clinical applications need to be proposed.