Extended Survival by Urgent Liver Retransplantation after Using a First Graft with Metastasis from Initially Unrecognized Donor Sarcoma

Ortíz, Jorge; Manzarbeitia, Cosme; Noto, Khristian; Rothstein, Kenneth D.; Araya, Víctor; Muñoz, Santiago J.; Reich, David J.

doi:10.1111/j.1600-6143.2005.00824.x

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…Autopsy and timely pathology allows early detection of cancer and rapid transplantation, but it has a low pickup rate and not always accepted by families. Therefore, radiography should also be considered as a method for donor assessment[ 21 ]. At present, experts have suggested some effective methods, such as that of the Second Opinion in Italy.…”

Section: Discussionmentioning

confidence: 99%

Gastric and intestinal ectopic pancreas: Two case reports

Zhang,

Zhao,

Zhang

et al. 2023

World J Clin Cases

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Time series analysis is a valuable tool in epidemiology that complements the classical epidemiological models in two different ways: Prediction and forecast. Prediction is related to explaining past and current data based on various internal and external influences that may or may not have a causative role. Forecasting is an exploration of the possible future values based on the predictive ability of the model and hypothesized future values of the external and/or internal influences. The time series analysis approach has the advantage of being easier to use (in the cases of more straightforward and linear models such as Auto-Regressive Integrated Moving Average). Still, it is limited in forecasting time, unlike the classical models such as Susceptible-Exposed-Infectious-Removed. Its applicability in forecasting comes from its better accuracy for short-term prediction. In its basic form, it does not assume much theoretical knowledge of the mechanisms of spreading and mutating pathogens or the reaction of people and regulatory structures (governments, companies, etc. ). Instead, it estimates from the data directly. Its predictive ability allows testing hypotheses for different factors that positively or negatively contribute to the pandemic spread; be it school closures, emerging variants, etc. It can be used in mortality or hospital risk estimation from new cases, seroprevalence studies, assessing properties of emerging variants, and estimating excess mortality and its relationship with a pandemic.

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Section: Discussionmentioning

confidence: 99%

Gastric and intestinal ectopic pancreas: Two case reports

Zhang,

Zhao,

Zhang

et al. 2023

World J Clin Cases

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“…Autopsy led to the early discovery of cancer and prompted urgent retransplantation in 1 patient. ( 26 ) Routinely performing autopsies is now not considered cost‐effective due to the low pickup rate and because it is not always accepted by families; therefore, a balanced use of radiological examinations should be part of the donor evaluation. An extensive instrumental/invasive evaluation of the donor is not viable or cost‐effective because donors in intensive care units are clinically unstable, with a risk of organ damage.…”

Section: Discussionmentioning

confidence: 99%

Donor‐Transmitted Cancers in Transplanted Livers: Analysis of Clinical Outcomes

Eccher¹,

Girolami²,

Marletta³

et al. 2020

Liver Transpl.

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The risk of transmission of malignancy from donor to recipient is low. However, this occurrence has dramatic consequences. Many reports of donor-derived cancers in liver transplant recipients have been published, but they have not been systematically summarized into a lucid and unified analysis. The present study is an attempt to provide clarity to this unusual but clinically important problem. We systematically reviewed all patient reports, patient series, and registries published on cancer transmission events through the end of December 2019. We identified a total of 67 publications with 92 transmission events. The most frequently transmitted cancers were lymphomas (30; 32.6%), melanomas (8; 8.7%), and neuroendocrine tumors (8; 8.7%). Most of the melanomas were metastasizing, whereas most of the lymphomas were localized to the graft. The median time to cancer diagnosis after transplantation was 7 months, with 78.1% of diagnoses established in the first year. Melanoma carried the worst prognosis, with no recipients alive at 1 year after cancer diagnosis. Lymphoma recipients had a better outcome, with more than 75% surviving at 2 years. A metastatic cancer carries a worse prognosis for recipients, and recipients with localized cancer can benefit from the chance to undergo transplantation again. The findings confirm the need to pay attention to donors with a history of melanoma but also suggest the need for a more careful evaluation of groups of donors, such as those dying from cerebral hemorrhage. Finally, recipients of organs from donors with cancer should be carefully followed to detect potential transmission.

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