Extended uterine receptivity for blastocyst implantation and full‐term fetal development in mice with vitrified–warmed ovarian tissue autotransplantation

Matsumoto, Hiromichi; Ezoe, Kenji; Mitsui, Akinori; Fukui, Emiko; Ochi, Masanori; Yoshizawa, Midori

doi:10.1007/s12522-012-0119-8

Cited by 7 publications

(6 citation statements)

References 38 publications

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“…Superovulation, in vitro fertilization and culture of embryos were performed as previously described [ 30 , 31 , 32 ]. Female mice were subjected to superovulation by intraperitoneal injection of 5 IU equine chorionic gonadotropin (eCG) (ASKA Animal Health, Tokyo, Japan) followed by 5 IU human chorionic gonadotropin (hCG) (ASKA Animal Health) 48 h later.…”

Section: Methodsmentioning

confidence: 99%

Impaired female fertility in tubulointerstitial antigen-like 1-deficient mice

Takahashi

Rahim

Miki

et al. 2016

Journal of Reproduction and Development

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Tubulointerstitial nephritis antigen-like 1 (Tinagl1, also known as adrenocortical zonation factor 1 [AZ-1] or lipocalin 7) is a matricellular protein. Previously, we demonstrated that Tinagl1 expression was restricted to extraembryonic regions during the postimplantation period and detected marked expression in mouse Reichert’s membranes. In uteri, Tinagl1 is markedly expressed in the decidual endometrium during the postimplantation period, suggesting that it plays a physical and physiological role in embryo development and/or decidualization of the uterine endometrium during pregnancy. In the present study, in order to determine the role of Tinagl1 during embryonic development and pregnancy, we generated Tinagl1-deficient mice. Although Tinagl1–/– embryos were not lethal during development to term, homologous matings of Tinagl1–/– females and Tinagl1–/– males showed impaired fertility during pregnancy, including failure to carry pregnancy to term and perinatal lethality. To examine ovarian function, ovulation was induced with equine chorionic gonadotropin (eCG) and human chorionic gonadotropin (hCG); the number of ovulated oocytes did not differ between Tinagl1–/– and Tinagl1flox/flox. In vitro fertilization followed by embryo culture also demonstrated the normal developmental potential of Tinagl1-null embryos during the preimplantation period. Our results demonstrate that Tinagl1 deficiency affects female mice and results in subfertility phenotypes, and they suggest that although the potential of Tinagl1–/– oocytes is normal, Tinagl1 is related to fertility in adult females but is not essential for either fertilization or preimplantation development in vitro.

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Section: Methodsmentioning

confidence: 99%

Impaired female fertility in tubulointerstitial antigen-like 1-deficient mice

Takahashi

Rahim

Miki

et al. 2016

Journal of Reproduction and Development

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“…The rate of live births was similar between VOAT mice that received an embryo transfer on day 4 of pseudopregnancy and those that received the transfer on day 5 [16]. In contrast, intact mice that received an embryo transfer on day 5 failed to support pregnancy [16]. Immunohistochemical analysis of the corpus luteum of day 8 pseudopregnant VOAT mice, with decidualization induced on day 5, exhibited less steroidogenesis and blood vessel formation compared with those of intact mice.…”

Section: Regulation Of Uterine Receptivity By Ovarian Steroid Hormonesmentioning

confidence: 78%

“…Our methods allowed VOAT mice to support pregnancy and full-term development; however, steroidogenesis and blood vessel formation in the corpus luteum were lower than those in intact mice [15]. The rate of live births was similar between VOAT mice that received an embryo transfer on day 4 of pseudopregnancy and those that received the transfer on day 5 [16]. In contrast, intact mice that received an embryo transfer on day 5 failed to support pregnancy [16].…”

Section: Regulation Of Uterine Receptivity By Ovarian Steroid Hormonesmentioning

confidence: 84%

Molecular and cellular events involved in the completion of blastocyst implantation

Matsumoto

Fukui

Yoshizawa

2015

Reprod Medicine & Biology

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Blastocyst implantation is an interactive process between the embryo and the uterus. The synchronization of embryonic development with uterine differentiation to a receptive state is essential for a successful pregnancy. The period of uterine receptivity for implantation is limited. Although implantation involves the interaction of numerous signaling molecules, our understanding of the hierarchical mechanisms that coordinate with the embryo-uterine dialogue is not yet sufficient to prevent infertility caused by implantation failure. This review highlights our knowledge on uterine receptivity and hormonal regulation of blastocyst implantation in mice. We also discuss the adhesion molecules, cross-linker proteins, extracellular proteins, and matricellular proteins involved in blastocyst implantation. Furthermore, our recent study reveals that selective proteolysis in an activated blastocyst is associated with the completion of blastocyst implantation after embryo transfer. A better understanding of uterine and blastocyst biology during the peri-implantation period would facilitate further development of reproductive technology.

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“…1B ) [ 28 ]. Therefore, the induction of uterine decidualization by stimulus is used experimentally as a tool to examine the effect of gene deficiencies on uterine function [ 1 , 2 , 29 , 30 ] and the potential for steroidogenesis in ovarian tissues transplanted into ovariectomized mice [ 31 , 32 ].…”

Section: Mouse As the Preferred Model For Implantation Studiesmentioning

confidence: 99%

“…As such, vitrified-warmed ovarian tissue autotransplantation (VOAT) into estrus cycle-ceased ovariectomized mice restored fertility and led to full-term fetal development for the transferred embryos, although steroidogenesis and blood vessel formation in the corpus luteum were less than those in intact mice [ 31 ]. Indeed, the rate of live births was similar between VOAT mice that received an embryo transfer on pseudopregnancy day 4 and those that received the transfer on day 5, whereas intact mice that received an embryo transfer on day 5 failed to support pregnancy [ 32 ]. For embryo transfer on pseudopregnancy day 5, oocyte warming and IVF can be performed on the day after mating a female with a vasectomized male.…”

Section: E 2 Is a Critical Determinant Of The Duramentioning

confidence: 99%

Molecular and cellular events during blastocyst implantation in the receptive uterus: clues from mouse models

Matsumoto

2017

Journal of Reproduction and Development

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The success of implantation is an interactive process between the blastocyst and the uterus. Synchronized development of embryos with uterine differentiation to a receptive state is necessary to complete pregnancy. The period of uterine receptivity for implantation is limited and referred to as the “implantation window”, which is regulated by ovarian steroid hormones. Implantation process is complicated due to the many signaling molecules in the hierarchical mechanisms with the embryo-uterine dialogue. The mouse is widely used in animal research, and is uniquely suited for reproductive studies, i.e., having a large litter size and brief estrous cycles. This review first describes why the mouse is the preferred model for implantation studies, focusing on uterine morphology and physiological traits, and then highlights the knowledge on uterine receptivity and the hormonal regulation of blastocyst implantation in mice. Our recent study revealed that selective proteolysis in the activated blastocyst is associated with the completion of blastocyst implantation after embryo transfer. Furthermore, in the context of blastocyst implantation in the mouse, this review discusses the window of uterine receptivity, hormonal regulation, uterine vascular permeability and angiogenesis, the delayed-implantation mouse model, morphogens, adhesion molecules, crosslinker proteins, extracellular matrix, and matricellular proteins. A better understanding of uterine and blastocyst biology during the peri-implantation period should facilitate further development of reproductive technology.

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Extended uterine receptivity for blastocyst implantation and full‐term fetal development in mice with vitrified–warmed ovarian tissue autotransplantation

Cited by 7 publications

References 38 publications

Impaired female fertility in tubulointerstitial antigen-like 1-deficient mice

Impaired female fertility in tubulointerstitial antigen-like 1-deficient mice

Molecular and cellular events involved in the completion of blastocyst implantation

Molecular and cellular events during blastocyst implantation in the receptive uterus: clues from mouse models

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