Extended vs. brief intermittent access to palatable food differently promote binge-like intake, rejection of less preferred food, and weight cycling in female rats

Kreisler, Alison D.; Garcia, Megg G; Spierling, Samantha R.; Bi, Hui; Zorrilla, Eric P.

doi:10.1016/j.physbeh.2017.03.039

Cited by 35 publications

(39 citation statements)

References 94 publications

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“…Descriptively, these individual differences were greater in rats with more restricted access (2-hr: ICC =0.78, 4-hr: ICC =0.75), though 8-hr rats showed them as well ( ICC= 0.56), in sharp contrast to chow controls ( ICC =0.09). Translationally, these and similar previous results(Cottone et al, 2008b; Kreisler et al, 2017; Parylak et al, 2012; Sinclair et al, 2015) may model individual differences in risk for developing binge-feeding behavior in people that follow diet patterns with restriction of food reward(Feeney et al, 2011; Garcia-Bailo, Toguri, Eny, & El-Sohemy, 2009). …”

Section: Discussionsupporting

confidence: 83%

“…Animal models of limited access to palatable foods have been used to study resulting changes in the appetitive qualities of certain foods (Cottone P, Sabino V, Steardo L, 2008; Cottone, Sabino, Steardo, & Zorrilla, 2008b; Johnson & Kenny, 2010; Klump, Racine, Hildebrandt, & Sisk, 2013; Kreisler, Garcia, Spierling, Hui, & Zorrilla, 2017; Parylak, Cottone, Sabino, Rice, & Zorrilla, 2012; Parylak, Koob, & Zorrilla, 2011; Rogers, 1985) and emotional function towards understanding dieting-related pathologic eating behavior in humans (Avena, Gold, Kroll, & Gold, 2012; Avena, Rada, & Hoebel, 2008; R. L. Corwin, Avena, & Boggiano, 2011; R.…”

Section: Introductionmentioning

confidence: 99%

“…Limiting access also often leads to reduced intake of the more available, but less preferred, food(Cottone P, Sabino V, Steardo L, 2008). The degrees of undereating of nonpreferred food vs. overeating of preferred food are dissociable, however, and undereating can persist despite normal bodyweight and adiposity(Johnson & Kenny, 2010; Kreisler et al, 2017). Undereating has been interpreted not to be corrective homeostasis/caloric conditioning alone, but rather food rejection due to an adjustment in reward function that leads to development of compulsive eating(Spierling et al, 2018) via negative reinforcement mechanisms(Cottone P, Sabino V, Steardo L, 2008; Cottone et al, 2008b; Johnson & Kenny, 2010; Kreisler et al, 2017; Parylak et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…The degrees of undereating of nonpreferred food vs. overeating of preferred food are dissociable, however, and undereating can persist despite normal bodyweight and adiposity(Johnson & Kenny, 2010; Kreisler et al, 2017). Undereating has been interpreted not to be corrective homeostasis/caloric conditioning alone, but rather food rejection due to an adjustment in reward function that leads to development of compulsive eating(Spierling et al, 2018) via negative reinforcement mechanisms(Cottone P, Sabino V, Steardo L, 2008; Cottone et al, 2008b; Johnson & Kenny, 2010; Kreisler et al, 2017; Parylak et al, 2011). Consistent with this hypothesis, abstinence from preferred foods is associated with hostile mood in humans(Wells, Read, Laugharne, & Ahluwalia, 1998) and, in animal models, elicits activation of amygdala stress circuitry(Cottone, Sabino, Roberto, et al, 2009; Teegarden & Bale, 2007), anti-reward adaptations(Johnson & Kenny, 2010), and a negative emotional state with psychomotor arousal and anxiety-, depressive-, and irritability-like behavior (Avena et al, 2008; Cottone P, Sabino V, Steardo L, 2008; Cottone, Sabino, Roberto, et al, 2009; Cottone et al, 2008b; Cottone, Sabino, Steardo, & Zorrilla, 2009; Iemolo et al, 2012; Spierling et al, 2018; Teegarden & Bale, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, limited access rats showed decreased thermogenic brown adipose tissue mass in direct relation to their degree of voluntary caloric restriction on non-access days(Kreisler et al, 2017); despite abstinence, they regained more weight following renewed access to preferred food(Kreisler et al, 2017; Montani et al, 2015). Both findings suggest thrifty metabolic adjustments.…”

Section: Introductionmentioning

confidence: 99%

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The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats

2018

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Many people restrict their palatable food intake. In animal models, time-limiting access to palatable foods increases their intake while decreasing intake of less preferred alternatives; negative emotional withdrawal-like behavior is sometimes reported. In drug addiction models, intermittent extended access drives greater changes in use than brief access. When it comes to palatable food, the impact of briefer vs. longer access durations within intermittent access conditions remains unclear. Here, we provided male rats with chow or with weekday access to a preferred, sucrose-rich diet (PREF) (2, 4, or 8 h daily) with chow otherwise available. Despite normal energy intake, all restricted access conditions increased weight gain by 6 weeks and shifted diet acceptance within 1 week. They increased daily and 2-h intake of PREF with individual vulnerability and decreased chow intake. Rats with the briefest access had the greatest binge-like (2-h) intake, did not lose weight on weekends despite undereating chow, and were fattier by 12 weeks. Extended access rats (8 h) showed the greatest daily intake of preferred food and corresponding undereating of chow, slower weight gain when PREF was unavailable, and more variable daily energy intake from week to week. Increased fasting glucose was seen in 2-h and 8-h access rats. During acute withdrawal from PREF to chow diet, restricted access rats showed increased locomotor activity. Thus, intermittent access broadly promoted weight gain, fasting hyperglycemia and psychomotor arousal during early withdrawal. More restricted access promoted greater binge-like intake and fat accumulation, whereas longer access promoted evidence of greater food reward tolerance.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats

2018

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Obesogenic Diet Cycling Produces Graded Effects on Cognition and Microbiota Composition in Rats

Kendig

Leigh

Hasebe

et al. 2023

Molecular Nutrition Food Res

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Scope The effects of diet cycling on cognition and fecal microbiota are not well understood. Method and Results Adult male Sprague‐Dawley rats were cycled between a high‐fat, high‐sugar “cafeteria” diet (Caf) and regular chow. The impairment in place recognition memory produced by 16 days of Caf diet was reduced by switching to chow for 11 but not 4 days. Next, rats received 16 days of Caf diet in 2, 4, 8, or 16‐day cycles, each separated by 4‐day chow cycles. Place recognition memory declined from baseline in all groups and was impaired in the 16‐ versus 2‐day group. Finally, rats received 24 days of Caf diet continuously or in 3‐day cycles separated by 2‐ or 4‐day chow cycles. Any Caf diet access impaired cognition and increased adiposity relative to controls, without altering hippocampal gene expression. Place recognition and adiposity were the strongest predictors of global microbiota composition. Overall, diets with higher Caf > chow ratios produced greater spatial memory impairments and larger shifts in gut microbiota species richness and beta diversity. Conclusion Results suggest that diet‐induced cognitive deficits worsen in proportion to unhealthy diet exposure, and that shifting to a healthy chow for at least a week is required for recovery under the conditions tested here.

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Intermittent High‐Fat Diet Intake Reduces Sensitivity to Intragastric Nutrient Infusion and Exogenous Amylin in Female Rats

Maske

Coiduras

Ondriezek

et al. 2020

Obesity

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Objective: Intermittent (INT) access to a high-fat diet (HFD) can induce excessive-intake phenotypes in rodents. This study hypothesized that impaired satiation responses contribute to elevated intake in an INT-HFD access model. Methods: First, this study characterized the intake and meal patterns of female rats that were subjected to an INT HFD in which a 45% HFD was presented for 20 hours every fourth day. To examine nutrient-induced satiation, rats received intragastric infusions of saline or Ensure Plus prior to darkness-onset food access. A similar design was used to examine sensitivity to the satiating effect of amylin. This study then examined whether an INT HFD influences amylin-induced c-Fos in feeding-relevant brain areas. Results: Upon INT HFD access, rats consumed meals of larger size. The anorexic response to intragastric Ensure infusion and exogenous amylin treatment was blunted in INT rats on both chow-only and INT-HFD days of the diet regimen, compared with chow-maintained and continuous-HFD rats. An INT HFD did not influence amylin-induced c-Fos in the area postrema, nucleus of the solitary tract, and lateral parabrachial nucleus. Conclusions: Impaired satiation responses, mediated in part by reduced sensitivity to amylin, may explain the elevated intake observed upon INT HFD access and may play a role in disorders of INT overconsumption, including binge eating.Obesity (2020) 28, 942-952.

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Extended vs. brief intermittent access to palatable food differently promote binge-like intake, rejection of less preferred food, and weight cycling in female rats

Cited by 35 publications

References 94 publications

The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats

The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats

Obesogenic Diet Cycling Produces Graded Effects on Cognition and Microbiota Composition in Rats

Intermittent High‐Fat Diet Intake Reduces Sensitivity to Intragastric Nutrient Infusion and Exogenous Amylin in Female Rats

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