Surface water flooding represents a significant hazard for many infrastructure systems. For example, residential, commercial, and industrial properties, water and wastewater treatment facilities, private drinking water wells, stormwater systems, or transportation networks are often impacted (i.e., in terms of damage or functionality) by flooding events. For large scale events, knowing where to prioritize recovery resources can be challenging. To help communities throughout North Carolina manage flood disaster responses, near real-time state-wide rapid flood mapping methods are needed. In this study, Height Above Nearest Drainage (HAND) concepts are combined with National Water Model river discharges to enable rapid flood mapping throughout North Carolina. The modeling system is calibrated using USGS stage-discharge relationships and FEMA 100-year flood maps. The calibration process ultimately provides spatially distributed channel roughness values to best match the available datasets. Results show that the flood mapping system, when calibrated, provides reasonable estimates of both river stage (or corresponding water surface elevations) and surface water extents. Comparing HAND to FEMA hazard maps both in Wake County and state-wide shows an agreement of 80.1% and 76.3%, respectively. For the non-agreement locations, flood extents tend to be overestimated as compared to underestimated, which is preferred in the context of identifying potentially impacted infrastructure systems. Future research will focus on developing transfer relationships to estimate channel roughness values for locations that lack the data needed for calibration.