Extending Shelf Life of Pasteurized Milk via Chitosan Nanoparticles

Shawkat, Sadeq Munееr; Al-Jawasim, Mohammed; Khaleefah, Luay Salam

doi:10.22207/jpam.13.4.62

Cited by 7 publications

(9 citation statements)

References 23 publications

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“…The aspect of these aggregated is in agreement with data reported in literature and could be correlated with similar sampledrying procedure, similar polymer molecular weight (MW) and similar deacetylation (DA) degree [67,68]. In fact, it was reported that bare CS NPs prepared by ionotropic gelation strategy and using CS with similar physical properties (MW and DA), showed the same shape (spherical) and the similar tendency to form similar necklace-shaped aggregates [68][69][70][71][72][73][74].…”

Section: Nanoparticles Preparation and Characterizationsupporting

confidence: 90%

Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities

et al. 2021

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The treatment of skin wounds poses significant clinical challenges, including the risk of bacterial infection. In particular due to its antimicrobial and tissue regeneration abilities chitosan (a polymeric biomaterial obtained by the deacetylation of chitin) has received extensive attention for its effectiveness in promoting skin wound repair. On the other hand, due to their intrinsic characteristics, metal nanoparticles (e.g., silver (Ag), gold (Au) or iron oxide (Fe3O4)) have demonstrated therapeutic properties potentially useful in the field of skin care. Therefore, the combination of these two promising materials (chitosan plus metal oxide NPs) could permit the achievement of a promising nanohybrid with enhanced properties that could be applied in advanced skin treatment. In this work, we have optimized the synthesis protocol of chitosan/metal hybrid nanoparticles by means of a straightforward synthetic method, ionotropic gelation, which presents a wide set of advantages. The synthesized hybrid NPs have undergone to a full physicochemical characterization. After that, the in vitro antibacterial and tissue regenerative activities of the achieved hybrids have been assessed in comparison to their individual constituent. As result, we have demonstrated the synergistic antibacterial plus the tissue regeneration enhancement of these nanohybrids as a consequence of the fusion between chitosan and metallic nanoparticles, especially in the case of chitosan/Fe3O4 hybrid nanoparticles.

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Section: Nanoparticles Preparation and Characterizationsupporting

confidence: 90%

Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities

et al. 2021

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“…77 6. Chitosan nanoparticles (CNPs)research conducted 78 showed that the addition of chitosan nanoparticles to milk prevents the microbiological development of vegetative cells. Nanomaterials improve microbiological quality, prevent spoilage and extend the shelf life to a maximum of 30 days.…”

Section: Pasteurizationmentioning

confidence: 99%

“…Thanks to these studies, it was shown that chitosan nanoparticles are a reusable material and do not lose their high antibacterial activity during the storage period. 78…”

Section: Pasteurizationmentioning

confidence: 99%

“…This allowed the shelf life of milk to be extended by 15 days. 78 There are already some commercial products on the market that use nanotechnology, such as a nylon-based nanocomposite. Hite Brewer Co. from South Korea uses Honeywell's Aegis OXCE nylon-based nanocomposite in its 1.6 L three-layer beer bottle, which gives the product a shelf life of over 6 months.…”

Section: Food and Function Reviewmentioning

confidence: 99%

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Nanoparticle applications in food – a review

et al. 2023

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“…For the formulation optimization of XYL-NP, the independent variables such as chitosan (0.01-0.1% w/v), 14 calcium chloride (1-5% w/v) 15 and sonication time (1-5 min) were used. The nanoparticles prepared were then evaluated with respect to the dependent variables such as particle size, polydispersity index (PDI) and entrapment efficiency as shown in Table 1 using Box -Behnken Design with Design of Expert Software.…”

Section: Optimization Of the Formulation Using Box-behnken Design (Bbd)mentioning

confidence: 99%

Xylometazoline Loaded Chitosan Nanoparticles: Fabrication, Optimization and Evaluation for Nasal Congestion

Attri¹,

Singh²,

Bhalla³

2022

IJPER

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Aim:The present study aims at exploring the development of xylometazoline hydrochloride loaded chitosan nanoparticles (XYL-NP) cross linked with calcium chloride for the treatment of nasal congestion. Materials and Methods: XYL-NP were prepared using different polymer like chitosan, cross linking agent calcium chloride and glacial acetic acid as a solvent enhancer using ionotropic gelation method, which was further optimized and validated by Box-Behnken Design. Further, these particles were characterised for size, morphology and evaluated for its release and permeability studies. Results: XYL-NP showed a particle size of 172+0.4 nm and a PDI of 0.27. The obtained charged nanoparticles showed encapsulation efficiency of 90.5%. Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM) studies showed nanoparticles have small size and smooth morphology and an in-vitro drug release of 81.2 %, following Peppas-korsemeyer release model.96.3% of the drug was permeated through the nasal mucosa of the goat in a time period of 8 hr. Conclusion: Release and permeation results shows the capability of the nanoparticles to retain large amount of XYL-NP inside the mucosa. Hence XYL-NP can be used in treating nasal congestion as the fabricated formulation has good bioadhesive and mucoadhesive property.

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Extending Shelf Life of Pasteurized Milk via Chitosan Nanoparticles

Cited by 7 publications

References 23 publications

Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities

Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities

Nanoparticle applications in food – a review

Xylometazoline Loaded Chitosan Nanoparticles: Fabrication, Optimization and Evaluation for Nasal Congestion

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